GenomeNet

Database: UniProt
Entry: Q20911
LinkDB: Q20911
Original site: Q20911 
ID   CUBN_CAEEL              Reviewed;        4047 AA.
AC   Q20911; Q23242;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 4.
DT   10-APR-2019, entry version 143.
DE   RecName: Full=Probable cubilin;
DE   Flags: Precursor;
GN   ORFNames=ZC116.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2005, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=12754521; DOI=10.1038/nbt829;
RA   Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA   Kasai K., Takahashi N., Isobe T.;
RT   "Lectin affinity capture, isotope-coded tagging and mass spectrometry
RT   to identify N-linked glycoproteins.";
RL   Nat. Biotechnol. 21:667-672(2003).
RN   [3]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-806; ASN-811; ASN-1762;
RP   ASN-2005; ASN-2645; ASN-3421; ASN-3787 AND ASN-3858, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=17761667; DOI=10.1074/mcp.M600392-MCP200;
RA   Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA   Taoka M., Takahashi N., Isobe T.;
RT   "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT   elegans and suggests an atypical translocation mechanism for integral
RT   membrane proteins.";
RL   Mol. Cell. Proteomics 6:2100-2109(2007).
CC   -!- FUNCTION: Cotransporter which plays a role in lipoprotein, vitamin
CC       and iron metabolism, by facilitating their uptake. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
DR   EMBL; Z74046; CAA98557.3; -; Genomic_DNA.
DR   EMBL; Z74473; CAA98557.3; JOINED; Genomic_DNA.
DR   PIR; T22812; T22812.
DR   RefSeq; NP_506157.3; NM_073756.5.
DR   UniGene; Cel.1419; -.
DR   SMR; Q20911; -.
DR   STRING; 6239.ZC116.3; -.
DR   iPTMnet; Q20911; -.
DR   EPD; Q20911; -.
DR   PaxDb; Q20911; -.
DR   PeptideAtlas; Q20911; -.
DR   PRIDE; Q20911; -.
DR   EnsemblMetazoa; ZC116.3; ZC116.3; WBGene00013855.
DR   GeneID; 179729; -.
DR   KEGG; cel:CELE_ZC116.3; -.
DR   UCSC; ZC116.3; c. elegans.
DR   CTD; 179729; -.
DR   WormBase; ZC116.3; CE42882; WBGene00013855; -.
DR   eggNOG; KOG3714; Eukaryota.
DR   eggNOG; ENOG410ZPX7; LUCA.
DR   HOGENOM; HOG000018673; -.
DR   InParanoid; Q20911; -.
DR   KO; K14616; -.
DR   OMA; EWDIRAG; -.
DR   OrthoDB; 4105at2759; -.
DR   PhylomeDB; Q20911; -.
DR   PRO; PR:Q20911; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00013855; Expressed in 3 organ(s), highest expression level in multi-cellular organism.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00041; CUB; 17.
DR   Gene3D; 2.60.120.290; -; 23.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 15.
DR   Pfam; PF00008; EGF; 2.
DR   Pfam; PF07645; EGF_CA; 3.
DR   SMART; SM00042; CUB; 23.
DR   SMART; SM00181; EGF; 8.
DR   SMART; SM00179; EGF_CA; 6.
DR   SUPFAM; SSF49854; SSF49854; 23.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS01180; CUB; 20.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 7.
DR   PROSITE; PS01187; EGF_CA; 3.
PE   1: Evidence at protein level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Lipid metabolism; Protein transport; Reference proteome;
KW   Repeat; Secreted; Signal; Transport.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23   4047       Probable cubilin.
FT                                /FTId=PRO_0000248516.
FT   DOMAIN      168    205       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      207    248       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      306    345       EGF-like 3; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      346    387       EGF-like 4; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      388    435       EGF-like 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      438    475       EGF-like 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      476    512       EGF-like 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      518    641       CUB 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN      645    763       CUB 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN      769    934       CUB 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN      934   1061       CUB 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     1065   1182       CUB 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     1188   1300       CUB 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     1304   1427       CUB 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     1428   1558       CUB 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     1560   1680       CUB 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     1691   1841       CUB 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     1955   2083       CUB 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     2207   2334       CUB 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     2335   2463       CUB 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     2467   2588       CUB 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     2590   2717       CUB 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     2721   2859       CUB 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     2996   3121       CUB 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     3127   3254       CUB 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     3255   3385       CUB 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     3387   3508       CUB 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     3515   3641       CUB 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     3645   3783       CUB 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   DOMAIN     3786   3900       CUB 23. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00059}.
FT   CARBOHYD     56     56       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD     92     92       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    127    127       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    215    215       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    224    224       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    528    528       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    537    537       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    583    583       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    775    775       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    806    806       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD    811    811       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD    942    942       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1133   1133       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1229   1229       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1294   1294       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1353   1353       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1513   1513       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1613   1613       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1631   1631       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1648   1648       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1674   1674       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1762   1762       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   1782   1782       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1866   1866       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1890   1890       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2005   2005       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:12754521,
FT                                ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   2016   2016       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2017   2017       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2193   2193       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2301   2301       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2305   2305       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2434   2434       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2599   2599       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2645   2645       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   2657   2657       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2692   2692       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2811   2811       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2845   2845       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2875   2875       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2988   2988       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3235   3235       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3421   3421       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   3461   3461       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3635   3635       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3770   3770       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3787   3787       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   3812   3812       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3858   3858       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   3930   3930       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    172    183       {ECO:0000250}.
FT   DISULFID    177    193       {ECO:0000250}.
FT   DISULFID    195    204       {ECO:0000250}.
FT   DISULFID    211    227       {ECO:0000250}.
FT   DISULFID    221    236       {ECO:0000250}.
FT   DISULFID    238    247       {ECO:0000250}.
FT   DISULFID    310    321       {ECO:0000250}.
FT   DISULFID    315    330       {ECO:0000250}.
FT   DISULFID    333    344       {ECO:0000250}.
FT   DISULFID    350    363       {ECO:0000250}.
FT   DISULFID    357    372       {ECO:0000250}.
FT   DISULFID    375    386       {ECO:0000250}.
FT   DISULFID    392    403       {ECO:0000250}.
FT   DISULFID    397    418       {ECO:0000250}.
FT   DISULFID    420    434       {ECO:0000250}.
FT   DISULFID    442    453       {ECO:0000250}.
FT   DISULFID    447    463       {ECO:0000250}.
FT   DISULFID    465    474       {ECO:0000250}.
FT   DISULFID    480    491       {ECO:0000250}.
FT   DISULFID    485    500       {ECO:0000250}.
FT   DISULFID    502    511       {ECO:0000250}.
FT   DISULFID    518    544       {ECO:0000250}.
FT   DISULFID    577    601       {ECO:0000250}.
FT   DISULFID    645    667       {ECO:0000250}.
FT   DISULFID    696    719       {ECO:0000250}.
FT   DISULFID    769    801       {ECO:0000250}.
FT   DISULFID    877    896       {ECO:0000250}.
FT   DISULFID   1065   1091       {ECO:0000250}.
FT   DISULFID   1120   1145       {ECO:0000250}.
FT   DISULFID   1188   1211       {ECO:0000250}.
FT   DISULFID   1234   1262       {ECO:0000250}.
FT   DISULFID   1304   1330       {ECO:0000250}.
FT   DISULFID   1428   1455       {ECO:0000250}.
FT   DISULFID   1488   1522       {ECO:0000250}.
FT   DISULFID   1560   1586       {ECO:0000250}.
FT   DISULFID   1614   1641       {ECO:0000250}.
FT   DISULFID   1691   1720       {ECO:0000250}.
FT   DISULFID   1955   1979       {ECO:0000250}.
FT   DISULFID   2006   2027       {ECO:0000250}.
FT   DISULFID   2207   2238       {ECO:0000250}.
FT   DISULFID   2265   2295       {ECO:0000250}.
FT   DISULFID   2335   2368       {ECO:0000250}.
FT   DISULFID   2395   2424       {ECO:0000250}.
FT   DISULFID   2467   2498       {ECO:0000250}.
FT   DISULFID   2590   2619       {ECO:0000250}.
FT   DISULFID   2646   2668       {ECO:0000250}.
FT   DISULFID   2721   2747       {ECO:0000250}.
FT   DISULFID   2786   2809       {ECO:0000250}.
FT   DISULFID   2996   3025       {ECO:0000250}.
FT   DISULFID   3052   3074       {ECO:0000250}.
FT   DISULFID   3127   3154       {ECO:0000250}.
FT   DISULFID   3181   3217       {ECO:0000250}.
FT   DISULFID   3255   3281       {ECO:0000250}.
FT   DISULFID   3315   3335       {ECO:0000250}.
FT   DISULFID   3387   3418       {ECO:0000250}.
FT   DISULFID   3445   3468       {ECO:0000250}.
FT   DISULFID   3515   3544       {ECO:0000250}.
FT   DISULFID   3645   3680       {ECO:0000250}.
FT   DISULFID   3708   3742       {ECO:0000250}.
FT   DISULFID   3786   3815       {ECO:0000250}.
FT   DISULFID   3845   3863       {ECO:0000250}.
SQ   SEQUENCE   4047 AA;  453276 MW;  F8A620A00A68F649 CRC64;
     MIPNLQLFLS LILFGLLNHV SSIDYEEIHI EDSYETRSRI LMVDGNVWLH AGKDKNITFK
     TTGNGRIYVD ETDVSKLPDI ASFKQLVGRI ENTSQMFTTL KSRQDTQTSA MRVVLNSAKH
     YLVALRNMTL EVNILKKWKT DKMARDMRRR GLLVKMTRQI IGINKLIAIN ACDPNKCSNG
     GTCIPSFGAK FTCLCPPHFT GTTCEADIDE CSVYNGTTAG CQNNGTCINN RGGFECQCQS
     GYHGSLCQYH MSACSKTFEL CGPHGHCIES IVDPTGQSSS DTTTYKCICD WGFKVSSDKN
     NPTCVDVNEC ESNPCHPGVD CINLPGSFVC SGCPKGYKTD GNVCIDVNEC EGEIRVCSPL
     SKCHNTLGSY YCDSCPTGYS GDGGNCVKDD SCVKNKCHKL ATCKVTDDGY SAVGDYTCYC
     PDGYVGDGIG EEGCVKSASN VCQNHNCVNA GKCKPTSDTE YKCECEAGFL GKFCEKTSPC
     QTNPCKNGGT CIAVENSAYC DCPEHFFGRA CEEEEEHCGS HFTHSSGNYT FDLQRSNKTE
     LSICDFVFNI PAANSAVVMT FTEFDKFTQE GSGPTDCAKT DANLTLYDGP EDSSSEFATF
     CGDSHSVHAP LSDTPITMTS TGAMLRFRGT QGSFTIKWET VERKCGYRSS KPEGIISVPQ
     NHQDIVCEWF ISAPGGKIIE VTIPPVSMHS KDIEKCDQNS LEIYDGYATY DKHRILETCS
     STLESQVVRT TGPFLTVAFI SNMLQSDAGL ETIRGFVLKY KFTTPDRECG AEIDNDSNDF
     SFSGVIESPN YGSLYPPNMD CTWKINGTLS NGSYSGDMVL KLTFDEYDVK SGFSANGPGM
     HYRSFRRLLP RNEVEYGIAP GFSRVFAYRN LFDMGTCTND FLKIHDGDGT LVQETCNPRR
     PPNVLTVNNP AAVLTFHSDS AEQGKGFRIQ YEMLCEKRVN GNGTIQTWNF PNGGAAGTCT
     YIIEAPKTHV ISVRFLTIGL RVLPMSECFY TPNAVETYEN YVEFSGGRTD NALFNRRYVC
     ARYPFVEGAW MSVSAARRLQ IKVGSDGNPM FKGLSLEYKT SDVGCGGVFS SMTGTISSPN
     YPEKYQPHMH CVYNLYVSWS KTVKLTFDVF DLEVTPAKSC EYDRVEIYTS YHNETVHGEL
     LGKFCGAMIP PSIYSTTNTM AVVFVSDRSV AGPGWNAKFE AVSRKTTCDF TLTAPSNNLI
     FDPQQLKFDK CTYHIAVHEN QRILIKMNNM SLPCDKSSLM FRNGPSETSP PFSSLPPESE
     ICTPKVNYMP VIRSFSNRVT IVYKSINSEG SFFNLTYETI TSGCGGRVDG LTGIVSAPQY
     PLGDKKNLKC DWTVAVALGN KVRFALTALD DLNSSDSGGF CPLFAANRID FFDSALQGNQ
     HLKRYCAKEM ASEPITSDDN ELIIKYVQSG GFQSKKIFGF SGHFTTLCNG IVHEAISGSI
     QSPGYPYKVY SNQFCTWTIK VPKGNRIVAT VHHFSISQKS YFEGGINCIT DMLKVDDTDL
     AEAEVTFKKT DYNITNSVNK YCDKAIPRVI RSRHNSMKLT YSSQGDPTNQ FWLSWNTLGC
     SRDITAPQQL IITKENIDPE VDEFECQYKI QAPIGKQINL KIDKMDILPI GTNCTYTKDF
     SGFAIFMSDS NKSGTPFQTY CSSINQQNIS SHTNELFLFL SMKKDKLKTN VFFNATVEFV
     DVPQSSQSDI CGQVINLERG KKNYITSPGY PSAYLPGIKC NFLINAPPGY HIEYALEKYY
     SPYYHDDRKT DKPRFMSPYT ANYTCKWYLA YNVGMLSFYE GNSSSSSPVE RLCDESDTVQ
     TFELYASQSL VIFEGASNYM SQKSGEGVRD QIGFVLSMIP KCGGVVYAES KPQTISLYHE
     GEGICNVTIK KKDPQDSEIN IRLEEYTKLN SSSTHTIDDR IDIYVGGVLK YTEMLKATDN
     TMQEYASDEE MMISVQNANA PHSAIIVVST DDKSCGGEVR HSQGTIYAPT RRLDKPFDCG
     WAISNSNGNT VTLSILDHNL KSTPNCTDSY IEIRANNSSG KLIKRQCDIS SIDSTEYESQ
     SLYVFLRYRP SASDGNDDDD DTPDIDQQDS NKRPLFKARY EKVSGGRPKS RYVSSPMIDN
     TEMMVWTLDI VDEKAGILVK FIDLYLPSPT SYLRFTESGE NDDVASSDYE EVTGVMAPAE
     KFFETNLIRV YGKLEKSDKF SFTWDPVPLN YRNLTLAKDK PAKVYDCGGD LTPTYEWDYF
     TNPLPAGQSF GYEENLHCRW IIRRPMFTGI ELKFDYLELE DVQNCAFDFV SFRLQFDDQP
     EENDDVDLSS VSKHCALVRS NNTFNFSVNR ALHIHFVTDR SRHGIGFKLK YRLTCNSFEH
     IRPGIFFEHT LTSPNYDGNF HTPSVWKCQY SLIIESNRKV SVEIVDLDIQ ENSPCSYNNA
     LILGNRFSEL VETHSQYSKS SKYCGKLEQG ERLNFTSARG RLFIKYNSGP NSRKGFKMII
     KEQLTECPSG VLHVDDNSPS RVLNSPEFPQ RIPNSVECEY VMAAPNGHRL MLTFDSENFD
     IDGNQKNCDL LDYIEIRDGP TVHSEVIGIY CGNQAPSTIF STTNFLYMKL HTSEYGKSRR
     FVATYGIATC GGTVMVRENV TTHITSPSFP YPFATPVQCQ WNVKSPNTHM IEAKVDHVWL
     FYNPNCTMEQ LMIRDGNSTA NPLIGPVCVP RHAPDVFTRS ASNQITVQFT SNSTTTRGGR
     QYCSNKKCGF DVAVTMSGEK CGGRITNLIG TLTPPGYPGK LLSHVKCIWD FKMKPGFIYR
     FKITFPGANA YHKFDNQVFR IAKQHCFPDV AVVEGFPPYD GAQYSTYFCK NETQITSITD
     TIRIVYDDSH TREMISAIGN DQPLNSTFYA PFTIDYMAIP ANSENQGCTL QINKNLTTEF
     HLRNKVNGKG VGLDSFCHVS IEKPANFESV HIEISDYKAD SELQPAGAKC FSWGAHLKIK
     SDEPVPIETT VCDGKSMKNK QSEMIYVNPQ IDLFISQLFR DQEGQQFNLT IEFQKCGGVI
     SSPNTGDITS PNFGSGLKYL PGSKCRWVLE APEGQIVKVK IVEMQIAYDH ECENDHLIIG
     EGRQADVNTI HKYCHKMDGE QEQKLEDRFK IIKSHGRYLT LIWVTNMKYE EAGWKIQYEF
     LNENEECGYH TSGMSGTIYT PMFGDKDYEN DLECVWDIQV PLGYHINLKF KDFDVETAEN
     CAKDQLLISQ EHSTRANSPN GDYYFLFQDE EKETPLCGIE HPKDFESESN RVRLNFTTDS
     QTTARGFRVN WEAECGAIYR LNHGVITSPY YPNGYPNDIT CTYLIAPPDQ NSVIAIKFAD
     FDLATMRTSF GRAPCEDDYL QIIDTGTDRV LHTFCASEPM PKDALVFKGA IGLKFVSDKS
     YYWMEEDNKY GRKGSKGFQL AYSINKCGDN IELREGTGFI TTVTSPAFPL PYTKDLDCVW
     NITTDPNRQL NIRFEEMKLE AFHDCSADYI EFFDSSDIMA NKTLGKFCGT MDKIPQYRIV
     TSGPNLLIHM RTDFNVNSGG FKLAVISSLG QKEGCGGKLT ATTSWQTLTS PKDEDGNYPP
     ALLCGWTISG PVDSQLQIRI DGVDTEQLEY PPGDRPSPEC IDALAIYDGQ EFFSPLLAGD
     ICTSGTPLPK ILYTSHRHAF ITFETDRDGT GRGFNISYSI VDSDCGGWLK ATNEIKTLVY
     KGITSDDNKE MNKERSHQRC RFMIQGPKTE PVIVNFQQFN IPSKAGDCSD SFVEIRDVGS
     LQECKHPACA REPNQRKITK LCGTHVPTSH VSNTNTIQII VSADIMPNKN QSRPSLKFEY
     NILDSCNRTI DTNTIKSGRL TSPNYPQVYS ENSTCVTNLQ SSNQKMLLVF NDFTLEEPNN
     VNKNCDYDYL MLKEGDSNGT YYCGSTLPKA LMTSGKDLTA LLKSDHSLNH AGYDASYYTV
     VSERDDQIQF ADSYELEGVI SSIGYPNGYN KSYTQIFTLR PPNSHDCSII FTDVSISMTQ
     LPEECFQPTE EYLEIEVKFK TQVKKARIRS CTFALKKARE LILEADNNDR YIKFAFKSDA
     KSENDGRGFK IRWKCHSIGK TQAVLPS
//
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