ID Q20916_CAEEL Unreviewed; 352 AA.
AC Q20916;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 2.
DT 27-MAR-2024, entry version 175.
DE SubName: Full=Nuclear receptor domain-containing protein {ECO:0000313|EMBL:CAA94833.2};
GN Name=nhr-192 {ECO:0000313|EMBL:CAA94833.2,
GN ECO:0000313|WormBase:F57A8.5};
GN ORFNames=CELE_F57A8.5 {ECO:0000313|EMBL:CAA94833.2}, F57A8.5
GN {ECO:0000313|WormBase:F57A8.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA94833.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA94833.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA94833.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993}.
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DR EMBL; BX284605; CAA94833.2; -; Genomic_DNA.
DR PIR; T22821; T22821.
DR RefSeq; NP_505584.2; NM_073183.2.
DR AlphaFoldDB; Q20916; -.
DR SMR; Q20916; -.
DR STRING; 6239.F57A8.5.1; -.
DR PaxDb; 6239-F57A8-5; -.
DR EnsemblMetazoa; F57A8.5.1; F57A8.5.1; WBGene00010180.
DR GeneID; 186431; -.
DR KEGG; cel:CELE_F57A8.5; -.
DR UCSC; F57A8.5; c. elegans.
DR AGR; WB:WBGene00010180; -.
DR WormBase; F57A8.5; CE34036; WBGene00010180; nhr-192.
DR eggNOG; ENOG502TGVN; Eukaryota.
DR GeneTree; ENSGT00970000195839; -.
DR HOGENOM; CLU_007368_3_0_1; -.
DR InParanoid; Q20916; -.
DR OMA; GGQEIYP; -.
DR OrthoDB; 2882410at2759; -.
DR PhylomeDB; Q20916; -.
DR Proteomes; UP000001940; Chromosome V.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45886:SF13; NUCLEAR HORMONE RECEPTOR FAMILY; 1.
DR PANTHER; PTHR45886; NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CAA94833.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 15..90
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 128..352
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 352 AA; 41363 MW; 04B770A495DC6FB3 CRC64;
MHLIPIKSEL ALEVPKLCEI CNRQAFGKHY GVLSCYACKM FFRRMSVQKL VYNCKWSNNC
FETSPYPLKC QSCRFQRCLD AGMYLEVHEN IVEFENGNQK VDELTTLLQN LLIMDSSRQH
KLKTFYSFDN PSLAEILENP GVVTSINQGP NYEVTPEEWA FLAIYSHISY FLNFDFVNEL
HDIDKKIIFQ HTILKLTYFC GVMRTVNEKR SKMMNPGGQE IYPDVILQLY EKSKSTLHRI
CCQPLDKLLE WEVTDEEYCL MNLLFFCNPA IPEISEDAVV KLSRQQNIYS NALFTLCQRN
NEQTAPERFS NFISLYLTIT KNSQEMENFF LIFNVHSPDF DFKKLVRETF HF
//
