ID Q21224_CAEEL Unreviewed; 223 AA.
AC Q21224;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 2.
DT 27-MAR-2024, entry version 156.
DE RecName: Full=palmitoyl-protein hydrolase {ECO:0000256|ARBA:ARBA00012423};
DE EC=3.1.2.22 {ECO:0000256|ARBA:ARBA00012423};
GN Name=ath-1 {ECO:0000313|EMBL:CAB00042.2,
GN ECO:0000313|WormBase:K04G2.5a};
GN ORFNames=CELE_K04G2.5 {ECO:0000313|EMBL:CAB00042.2}, K04G2.5
GN {ECO:0000313|WormBase:K04G2.5a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB00042.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB00042.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB00042.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 2
CC family. {ECO:0000256|ARBA:ARBA00006499}.
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DR EMBL; BX284601; CAB00042.2; -; Genomic_DNA.
DR PIR; T23324; T23324.
DR RefSeq; NP_492213.1; NM_059812.5.
DR AlphaFoldDB; Q21224; -.
DR SMR; Q21224; -.
DR ESTHER; caeel-K04G2.5; LYsophospholipase_carboxylesterase.
DR EPD; Q21224; -.
DR PaxDb; 6239-K04G2-5; -.
DR PeptideAtlas; Q21224; -.
DR EnsemblMetazoa; K04G2.5a.1; K04G2.5a.1; WBGene00010564.
DR EnsemblMetazoa; K04G2.5a.2; K04G2.5a.2; WBGene00010564.
DR EnsemblMetazoa; K04G2.5a.3; K04G2.5a.3; WBGene00010564.
DR EnsemblMetazoa; K04G2.5a.4; K04G2.5a.4; WBGene00010564.
DR UCSC; K04G2.5; c. elegans.
DR AGR; WB:WBGene00010564; -.
DR WormBase; K04G2.5a; CE27390; WBGene00010564; ath-1.
DR GeneTree; ENSGT00940000173516; -.
DR HOGENOM; CLU_049413_3_5_1; -.
DR OrthoDB; 4670340at2759; -.
DR PhylomeDB; Q21224; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00010564; Expressed in embryo and 4 other cell types or tissues.
DR ExpressionAtlas; Q21224; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IBA:GO_Central.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003140; PLipase/COase/thioEstase.
DR PANTHER; PTHR10655; LYSOPHOSPHOLIPASE-RELATED; 1.
DR PANTHER; PTHR10655:SF17; PALMITOYL-PROTEIN HYDROLASE; 1.
DR Pfam; PF02230; Abhydrolase_2; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CAB00042.2};
KW Proteomics identification {ECO:0007829|EPD:Q21224,
KW ECO:0007829|PeptideAtlas:Q21224};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 7..221
FT /note="Phospholipase/carboxylesterase/thioesterase"
FT /evidence="ECO:0000259|Pfam:PF02230"
SQ SEQUENCE 223 AA; 24335 MW; 305C376EF0D30E10 CRC64;
MSAVSNGNPS IVSPRGEHKG TLIFLHGLGD QGHGWADAFK TEAKHDNIKF ICPHSSERPV
TLNMGMRMPA WFDLFGLDPN AQEDEQGINR ATQYVHQLID AEVAAGIPAS RIAVGGFSMG
GALAIYAGLT YPQKLGGIVG LSSFFLQRTK FPGSFTANNA TPIFLGHGTD DFLVPLQFGQ
MSEQYIKKFN PKVELHTYRG MQHSSCGEEM RDVKTFLSAH IAH
//
