ID Q21530_CAEEL Unreviewed; 189 AA.
AC Q21530;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 154.
DE RecName: Full=E3 ubiquitin-protein ligase MARCHF5 {ECO:0000256|ARBA:ARBA00040151};
DE AltName: Full=Membrane-associated RING finger protein 5 {ECO:0000256|ARBA:ARBA00043185};
DE AltName: Full=Membrane-associated RING-CH protein V {ECO:0000256|ARBA:ARBA00043044};
DE AltName: Full=RING-type E3 ubiquitin transferase MARCHF5 {ECO:0000256|ARBA:ARBA00043231};
GN ORFNames=CELE_M110.3 {ECO:0000313|EMBL:CAA90260.1}, M110.3
GN {ECO:0000313|EMBL:CAA90260.1, ECO:0000313|WormBase:M110.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA90260.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA90260.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA90260.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284602; CAA90260.1; -; Genomic_DNA.
DR PIR; T23747; T23747.
DR RefSeq; NP_495728.1; NM_063327.4.
DR AlphaFoldDB; Q21530; -.
DR STRING; 6239.M110.3.1; -.
DR EPD; Q21530; -.
DR PaxDb; 6239-M110-3; -.
DR EnsemblMetazoa; M110.3.1; M110.3.1; WBGene00010913.
DR GeneID; 187472; -.
DR KEGG; cel:CELE_M110.3; -.
DR UCSC; M110.3; c. elegans.
DR AGR; WB:WBGene00010913; -.
DR WormBase; M110.3; CE02276; WBGene00010913; -.
DR eggNOG; KOG3053; Eukaryota.
DR GeneTree; ENSGT00390000009948; -.
DR HOGENOM; CLU_1476423_0_0_1; -.
DR InParanoid; Q21530; -.
DR OMA; KFCFGTE; -.
DR OrthoDB; 2718337at2759; -.
DR PhylomeDB; Q21530; -.
DR PRO; PR:Q21530; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00010913; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46283:SF2; AT07234P-RELATED; 1.
DR PANTHER; PTHR46283; E3 UBIQUITIN-PROTEIN LIGASE MARCH5; 1.
DR Pfam; PF12906; RINGv; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51292; ZF_RING_CH; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 8..73
FT /note="RING-CH-type"
FT /evidence="ECO:0000259|PROSITE:PS51292"
SQ SEQUENCE 189 AA; 22119 MW; E1F95E57C976DE83 CRC64;
MALEIDGNEQ ETEKYCKFCF GTESDNALSF VHPCRCRGSI HWVHHQCLAM WFSKANAVQQ
VMCIQCQTRY QKQLTLKSWK SWTIPRFGID KFGLLEITVD LWITWRTVSG FVGMMNGTKG
IFREIILCTM WKCFVASGRR FCYYGNLGLR LASSIFRVSI DDYEERREIK ARLPTDMHWE
EISQSSVLN
//
