ID Q21539_CAEEL Unreviewed; 125 AA.
AC Q21539;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE SubName: Full=14-3-3 domain-containing protein {ECO:0000313|EMBL:CAA98135.1};
GN ORFNames=CELE_M117.3 {ECO:0000313|EMBL:CAA98135.1}, M117.3
GN {ECO:0000313|EMBL:CAA98135.1, ECO:0000313|WormBase:M117.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA98135.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA98135.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA98135.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the 14-3-3 family.
CC {ECO:0000256|ARBA:ARBA00006141}.
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DR EMBL; BX284604; CAA98135.1; -; Genomic_DNA.
DR PIR; T23756; T23756.
DR RefSeq; NP_502236.1; NM_069835.1.
DR AlphaFoldDB; Q21539; -.
DR SMR; Q21539; -.
DR STRING; 6239.M117.3.1; -.
DR PaxDb; 6239-M117-3; -.
DR EnsemblMetazoa; M117.3.1; M117.3.1; WBGene00010919.
DR GeneID; 187477; -.
DR KEGG; cel:CELE_M117.3; -.
DR UCSC; M117.3; c. elegans.
DR AGR; WB:WBGene00010919; -.
DR WormBase; M117.3; CE06201; WBGene00010919; -.
DR eggNOG; KOG0841; Eukaryota.
DR GeneTree; ENSGT01090000260040; -.
DR HOGENOM; CLU_1994670_0_0_1; -.
DR InParanoid; Q21539; -.
DR OMA; HKSRIAY; -.
DR OrthoDB; 920089at2759; -.
DR PhylomeDB; Q21539; -.
DR Reactome; R-CEL-165159; MTOR signalling.
DR Reactome; R-CEL-166208; mTORC1-mediated signalling.
DR Reactome; R-CEL-170968; Frs2-mediated activation.
DR Reactome; R-CEL-2028269; Signaling by Hippo.
DR Reactome; R-CEL-392517; Rap1 signalling.
DR Reactome; R-CEL-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR Reactome; R-CEL-450513; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
DR Reactome; R-CEL-5625740; RHO GTPases activate PKNs.
DR Reactome; R-CEL-5673000; RAF activation.
DR Reactome; R-CEL-5674135; MAP2K and MAPK activation.
DR Reactome; R-CEL-5675221; Negative regulation of MAPK pathway.
DR Reactome; R-CEL-6804114; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
DR Reactome; R-CEL-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
DR Reactome; R-CEL-9614399; Regulation of localization of FOXO transcription factors.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00010919; Expressed in adult organism and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.190.20; 14-3-3 domain; 1.
DR InterPro; IPR000308; 14-3-3.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR023410; 14-3-3_domain.
DR PANTHER; PTHR18860; 14-3-3 PROTEIN; 1.
DR PANTHER; PTHR18860:SF160; 14-3-3 PROTEIN ZETA; 1.
DR Pfam; PF00244; 14-3-3; 1.
DR PRINTS; PR00305; 1433ZETA.
DR SUPFAM; SSF48445; 14-3-3 protein; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 1..93
FT /note="14-3-3"
FT /evidence="ECO:0000259|Pfam:PF00244"
SQ SEQUENCE 125 AA; 14248 MW; D6599B3877AAAC12 CRC64;
MVADHFRYLV QYDDINREEH AHKSRIAYQE ALGIAKDKMQ PTHPIRLGLA LNASALNFDV
LNLPKEANEI AQSALDSAHR ELEKMKSSLD SYDISNLKRA RTLYDLLKST HEQRVDGKEG
EEADN
//
