ID   Q21L12_SACD2            Unreviewed;       787 AA.
AC   Q21L12;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=von Willebrand factor, type A {ECO:0000313|EMBL:ABD80617.1};
GN   OrderedLocusNames=Sde_1355 {ECO:0000313|EMBL:ABD80617.1};
OS   Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Saccharophagus.
OX   NCBI_TaxID=203122 {ECO:0000313|EMBL:ABD80617.1, ECO:0000313|Proteomes:UP000001947};
RN   [1] {ECO:0000313|EMBL:ABD80617.1, ECO:0000313|Proteomes:UP000001947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2-40 / ATCC 43961 / DSM 17024
RC   {ECO:0000313|Proteomes:UP000001947};
RX   PubMed=18516288; DOI=10.1371/journal.pgen.1000087;
RA   Weiner R.M., Taylor L.E.II., Henrissat B., Hauser L., Land M.,
RA   Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H.,
RA   Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R.,
RA   Richardson P.M., Borovok I., Hutcheson S.;
RT   "Complete genome sequence of the complex carbohydrate-degrading marine
RT   bacterium, Saccharophagus degradans strain 2-40 T.";
RL   PLoS Genet. 4:E1000087-E1000087(2008).
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DR   EMBL; CP000282; ABD80617.1; -; Genomic_DNA.
DR   RefSeq; WP_011467837.1; NC_007912.1.
DR   AlphaFoldDB; Q21L12; -.
DR   STRING; 203122.Sde_1355; -.
DR   KEGG; sde:Sde_1355; -.
DR   eggNOG; COG2304; Bacteria.
DR   HOGENOM; CLU_012610_0_0_6; -.
DR   OrthoDB; 798937at2; -.
DR   Proteomes; UP000001947; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001947};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..787
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004199755"
FT   TRANSMEM        592..613
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          49..240
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          540..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..567
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..649
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..667
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        668..686
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        687..749
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   787 AA;  87156 MW;  4A8C160BE1DE1688 CRC64;
     MLKCWQAFIG LVLMLGLAAS AGAQPELNLA QASQEIESKL ADRSGKPADV RLVIDVSGSM
     KRNDPANLRQ PAVDLLMQLL PEGSKAGVWT FGKWVNMLVP HQVVDEQWRS LGRAKASEIN
     SVGLYTNIGE ALEKAAYDLD AASDEYAKHI ILLTDGMVDI DKQPDKNTQE WRRIVDEVLP
     KLKAAGYTIH TVALSDNADN NLLKKLSLQT DGIASVAHTA DDLMKIFLGT FDAAAPAEQV
     PLAGNQFVID SSVEEFTALI FRKNPADLTE LIGPDQTVYS AASQAADASW HRADNYDLIT
     IKQPLEGEWG LSVDMDDDSR VTVVSNLNLR VKAMANNVYI GHDQLLSLVL QEDGKTITRP
     EFLELMTITA KIMAGNNEEV LAEFWQNELT DGEPPLDGRY LEDLPTFEKE GVYELTVVVD
     GKSFVREFKH SFSVRQPFNA EVEKQFSDGE LNFILKVESL SSDVRVDKTQ IVASITSPSK
     RKMVKPLDLT KMDTWQTELM PDDEGMYFID IRIKGSTLDG SPFESYITDV KFKFSHEGGF
     SEEQEPIVDP AKKEEKETKK AEPEEPAKPT DEEGEAEAQE AESEPQQPVP AWLLYSAIGI
     GNLLLFVGGY FIVRKLLGSG SSDEDLLEQF SEESVEEATS PKEEPKPVDD EEEPPMEDLD
     PATADDVVEE PEPAKEQEKV QEPEPVEEPQ EEQLEEPAMD MLGEPDDAED IAEPEGYDAV
     DDGIDDLDEM ALDEPEPDAE EPEPQDEDDD MVAAMLKAQG LDLADDELDD AISNLIDDLD
     DDEEENK
//