ID Q21PC0_SACD2 Unreviewed; 614 AA.
AC Q21PC0;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN OrderedLocusNames=Sde_0195 {ECO:0000313|EMBL:ABD79459.1};
OS Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Cellvibrionaceae; Saccharophagus.
OX NCBI_TaxID=203122 {ECO:0000313|EMBL:ABD79459.1, ECO:0000313|Proteomes:UP000001947};
RN [1] {ECO:0000313|EMBL:ABD79459.1, ECO:0000313|Proteomes:UP000001947}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2-40 / ATCC 43961 / DSM 17024
RC {ECO:0000313|Proteomes:UP000001947};
RX PubMed=18516288; DOI=10.1371/journal.pgen.1000087;
RA Weiner R.M., Taylor L.E.II., Henrissat B., Hauser L., Land M.,
RA Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H.,
RA Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R.,
RA Richardson P.M., Borovok I., Hutcheson S.;
RT "Complete genome sequence of the complex carbohydrate-degrading marine
RT bacterium, Saccharophagus degradans strain 2-40 T.";
RL PLoS Genet. 4:E1000087-E1000087(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP000282; ABD79459.1; -; Genomic_DNA.
DR RefSeq; WP_011466683.1; NC_007912.1.
DR AlphaFoldDB; Q21PC0; -.
DR STRING; 203122.Sde_0195; -.
DR KEGG; sde:Sde_0195; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_6_4_6; -.
DR OrthoDB; 384988at2; -.
DR Proteomes; UP000001947; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001947}.
FT DOMAIN 16..285
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 285..539
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 614 AA; 69560 MW; 460DB2282E139D99 CRC64;
MVTRINPCEW KPQGVDDLEP NAWEGLRENK QHAAVLAGAG AGKTEFLAQK AAYLLQTGIC
SDPNRILAIS FKNDAARVLK ERVNLRCAPE QSRRFESFTY DGFTKFLLDR FRLAIPEPYA
PPPDYNIYFP NKGTFQEFLN NQKIRGVNVY QLQKDIANLP LPAGQHNYLA LKSYWQCRLT
SDEVALSFQM INRLIEYLIR SNPNIKHALR STYPFVFLDE FQDTTSPQYE LLKFIFLESN
SLITAVGDDK QQIMGWAGAL PEAFNVFNQD FGAKNFDLVS NWRSHPELVS MQHAIAQMIT
PGLTQPEAKN TKNMKGDVAA IWGYSDRNDE IQGVSNWISE QINSGTKAHE LAILVRTHAD
KLEVEIAPHL LNKGISIRNV ARIVDGIAIQ DILTEKLTTI ILPFLYLGVL ERSPENWNRA
LISLCALEGV DFVDERAHSQ QQDRLQYFSR LLRQDLSNGN FHKGRINPTI SSILAFLTED
AIRSSISEYK QDRDYNRVLN GIVSLLEECA DCSSSWLEAL DRFQGVDQVP LMTIHKSKGL
EFQTIIFFGL DAKTWWSLTP DNPEELRSFF VAFTRAKQST FFTSCSQTGN PVTWIEEILT
SVGVNKLAGP GCEN
//
