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Database: UniProt
Entry: Q22AH6_TETTS
LinkDB: Q22AH6_TETTS
Original site: Q22AH6_TETTS 
ID   Q22AH6_TETTS            Unreviewed;      3412 AA.
AC   Q22AH6;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=IP3 receptor calcium ion channel protein {ECO:0000313|EMBL:EAR82298.2};
GN   ORFNames=TTHERM_01205340 {ECO:0000313|EMBL:EAR82298.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR82298.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662483; EAR82298.2; -; Genomic_DNA.
DR   RefSeq; XP_001029961.2; XM_001029961.2.
DR   EnsemblProtists; EAR82298; EAR82298; TTHERM_01205340.
DR   GeneID; 7832198; -.
DR   KEGG; tet:TTHERM_01205340; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EAR82298.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2947   2966       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3004   3028       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3116   3138       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3158   3178       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3190   3215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3227   3250       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    157       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      358    414       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED      379    399       {ECO:0000256|SAM:Coils}.
FT   COILED      661    695       {ECO:0000256|SAM:Coils}.
FT   COILED     1477   1497       {ECO:0000256|SAM:Coils}.
FT   COILED     1738   1758       {ECO:0000256|SAM:Coils}.
FT   COILED     2916   2936       {ECO:0000256|SAM:Coils}.
FT   COILED     3046   3066       {ECO:0000256|SAM:Coils}.
FT   COILED     3388   3408       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3412 AA;  406421 MW;  76A8FCC28CFA0502 CRC64;
     MRSNKKLLHY GALVSIIIPE NQGMFLYSDG FIKNNIRAES FTYGETDFYG CLFLITPKYE
     TKMLTSMNKQ NIQDDYSQIN QKNFDLLVRE LETNDMIFQK NKGKAISYGE EFQLLHFKSR
     KFLSINQDSQ GGELQNNYTL RLSEISNEKT LFKVGAAFKH QSDSSKVVKF EDLIHFCCCP
     DREAFVYYVK KKDKVSFNKP MILKSQVDMN QSQDFTKSLN NQSYSEISSV YNDQQGDDQK
     YQFYVGYDKK CYFKLKYFSE LEQNTNQIFF GDIFCINSYE NSTFLQCLVT TKQSEPQRQP
     KIIAEKTQLI HIQKLKDDLK VQRDRHNNAI LFFQESNNFD YNSSLSLWKI EGKEMNTGGF
     IYEGDLFRLK NIKTNMYLMV KSKEQIKSQE LKREFLERTK NIDYLDKKEE LYPQFLIYLV
     SHVIQPSVYE QSGRDIFLID QSQSESGTVS FQYTDEDTLF TFEKVSNQQV QTEGNNISPL
     KYEDFFRIKH FKTQQYFTEY IKKEIEQGDD SGFEQLLRQK YFTIKMKPSV EKREVFKLYK
     SQHQEIWETT FMLSCIPVIR KRTKDLKNLK SFIIHQKSNT SDKQFDKFRQ KIKNLNLCLK
     MLHEFCYDEN ERMQDMQLDV LSLEIGLVNG KRQKLLKQYD LITDCARIIK EIDKTFYVKN
     KILTKNKIEQ VENKNEQVEN KIDQVENNIE EVQETLILIY QFLIKASFNN PDNQLECAKY
     FPLMVEHIGL NVEAEKCIRY ILADNIKLLQ SVDQPLVKSR CFLGDEQEGQ KQYVEFNRII
     DDLISSSKNQ FYQNQSNNSA MDLSPYTREQ SFTLSQHFLR RFKEAQQSLD QQKYDKMWLE
     KQEILHYFNS IIKYNSIGLT YNQTEVAKII IKGTFDQMQG SESYKQELYP IRSTIHNQLT
     FKINGRDQEF EEYLIEKDNN KKYRKFLQIQ LKLYANLCYG RNYECINKIK EIISFNALKH
     YIQMFENKIK NGQGDNDVLD DFSSSLYSII YCTYLDKQPY IERKVPKLIH TYHIYNFQHR
     SYDNFKERSH LAQQDNIGFS NQQSLEKEVI NKLNLENGGQ SFDQVQSANN SPEPLLNINQ
     QNENQYNIDI SFSNSFQQKR QSSLQRSISQ QSQEKMSVDQ LKDDEKWLIS NVKDFLKNLN
     GKQNRRANLI VKVVRLIQKL YSFESIKDKE DQREIFEALI WLFRSQFSLK KLNKINQDDN
     VESSQNHERR SKVLSEYSIQ ENVQVEKSEK VKKIVKKIPK IQDDQLLFYT QIKNLNEFIR
     LIDEEKSKDA KVKEEIKYNI QTKMTIMQIF KQYIDLRREN YLKSIIDFII KILPDMENSD
     ERKIKEKLEN EIDILMPSNN LPDEPFQLKE KEDFDLLGVT SKFASGLVSG ITNNLKDAVG
     KVIGSEQKEY VLSKEEQPSI HSLDFFLEKD DDNKKNEYQK DVKSSQKFIW MLLNTFLNSS
     DYKLNCSILK ILFFNFSQCR NLIRSVKQCQ IIIDRVDKNE EKIAKDLEER IKNFNIQCEK
     SETWFIEVTK KQNQETMKDV SSKLKDLNYM FFCPKLITNQ QGNLIYEEKE KKPENIIMSR
     QFMIRNLDAH NSVITLIKDS LKIFKSFKEY DNTVEQQVIY IECFTFLKYF CIGGNKLNKK
     LLYNQIDFFM EMLNYLELGQ TDLIIEIYKD NYKAITEVND VTINAVLKKI MHFEDSQNQY
     EEREQKISQG HLPKYVDFFY QICIFKQVPV QQNIHKIIIA LQDLANLQDF LFMEKVVNKN
     QSRNNQDQNR LYKDMKQKDE YQFCFDKLSV EQYGNNNIPY VYHSKVLELI LLLLENSDQG
     AKYFVQKLKN LLPAKYLLRE MTKKGDIFCS QDLPQFYCYT QIKRYCFKLF NIFYCNQEGL
     KEIQDMIKRM ENMNQFIYIE LFKVSEALYR YFNIQESKQK VINFKKREKN SNISNFDIDN
     ILGENIIDKG EVDKMQEEKQ KDYNQLVNLL VQQYPYLNEA KEKKLVKLSE YLNHLFNEVW
     PVISFLFKQI EEYKQAVEQS SYGGIQKEDF EQFKPYTQFK DWFLESVAIL LMQSYNSCKN
     NDKVAVDIQK EVVIDEEVAG DFNRYIKSYQ KDLGKSYEDI EIQQIFFAVK PKERLILNYQ
     NQINYPSVEN IINLPLQNIL SSKNNNDQFV RKCLLNILIN PKIKDNIVQE RKKLIYCIQS
     IQNITENIDF LSLEFLLQKI IQYIPQCFQE FVKGHNKEDH NILIEILRFL HDFILYSQED
     EEVDIENKNK INFNEDDEDT IKNLKIQQDT LGIQDIGDQK QDTRSRKNAN DFTRKKHQNL
     LAKFNLPYIL LETLCSDSNK VDYFQNHLCR KIFNSVIMLF IQLLDGGNLI VQEQLYSFFI
     KEENSEKFFE IIHQFLILKI QNKNSQKTTI FDQVEYELDH IDLVYRSKDK FVGILEILKL
     LQLVCENHNS NLQNYIRHQT KSRNNYNLIQ DVIQVIDSQI RVSNKDNFKQ ININQQNIEV
     LCQAFETLTE FVQGPCKQNQ LELAESPIIE IIAGILDLGL EKEKMGRGRR STDIRNSQRH
     SSLNQLNNNK RQSLKYIYDE NELKEQTQLK IINYLKQEVK SEYFKNLIQK KFSEANKQED
     WMIQKAKYKS LITIESILEG NKVKKIVKKI EKGINMKLLN LNMLSTFNKF KIAKQKEIPY
     TEELFGRGDV EIEDIVKQNE NENQSDKTNK KDVNLRQYCD KVIEIGFKCL ILKNYYNNLT
     DESNYDKEEN EGQKKDANDE DDEDEDLEDQ DYEDLIDDED EDESQSYYAL KVENNDNQEQ
     VNNGILKNKQ PNSNQPQINH HDNAHSNQGN QEKYEIEQPQ QDYIDLYQEN TELNKRPDQV
     FFQKYLIELE INYQGQLSKV YFPKPPIANS LNQALVKRFE LDAQRQSTKA KVLDLQQKSQ
     LLISEMKYEY QFNNLLLMII PKNQFLIKFL NTILKNKQKN QKNDDEDDEI QNQKNEEQLN
     VDLLETFNFW SFIFTIISNL CIILVLEENH TMNGQNIGSF LQNSYQFDEE PYVKIFVQFK
     QSDFIIVFYI FSIFAVIFQA LAFFIYWYKN HQFLFSEYVF NNQKIVKQKQ REIKYKQDKL
     DEENEQIQGK ILRIWYNFLF YFQYKLYFQL NYELKYRLYS SYPQIIPFFS YQCLQLTITI
     LSIINPIPCA LMVLLYIFTR YPELKNILQA IYKPRKQILL TVALLCLSTY FFSLLYYYNF
     YQDFDPYCVS IWKCFTFILV QTFVAEGGFL GVIFPDYTDN WGFTLRIIAD FAYVFFINIL
     VTQILSGTII DQFAQLREET QARQEDINTV CFICGQSVSE LEKRKNKKGQ SFRDHIELEH
     SKWNYINFMQ YLDSKKETDL SGFESFVNQR RQNHDISWFP IRQDEEEDNK RQEGDDINFE
     NIEQQIQLKK KKELGGLEQN WQLVGIKIED INNRIIQVEN ELKKKTIKKK DD
//
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