ID Q22AX6_TETTS Unreviewed; 739 AA.
AC Q22AX6;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 2.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=Tetratricopeptide repeat protein {ECO:0000313|EMBL:EAR82438.2};
GN ORFNames=TTHERM_01142720 {ECO:0000313|EMBL:EAR82438.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR82438.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662712; EAR82438.2; -; Genomic_DNA.
DR RefSeq; XP_001030101.2; XM_001030101.3.
DR AlphaFoldDB; Q22AX6; -.
DR STRING; 312017.Q22AX6; -.
DR EnsemblProtists; EAR82438; EAR82438; TTHERM_01142720.
DR GeneID; 7832041; -.
DR KEGG; tet:TTHERM_01142720; -.
DR eggNOG; KOG2003; Eukaryota.
DR HOGENOM; CLU_010738_1_0_1; -.
DR InParanoid; Q22AX6; -.
DR OMA; RIKIMHN; -.
DR OrthoDB; 312444at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44117; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR PANTHER; PTHR44117:SF1; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR Pfam; PF12895; ANAPC3; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 11.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 5.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 188..221
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 227..260
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 533..566
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 567..600
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 601..634
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 109..143
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 85241 MW; 741A1DC94C9D3FD6 CRC64;
MNTTQSQFDA QQTQFQQQAN TSKYNFEGVK QNPPPTGYAQ LQSRRGPGPT RSGPTGADRP
MTSIKAVVRN PQSQEQKQVK IDKVPDQSPE SNFKQQEKEI NQLLEASALA KIKGNLSEAL
EKAKDAVNKE KLLRRQKENM NQADSINIEL SFTVAYNLAN QLQANGIYQE ALQKYSDIIK
SKIYPQAYKL RVNMGNIYFQ QEKYSAAIKM YKMVYDWLPP TSKEMRFQVL KNIGHAYVKE
GKFDDAINTY ETIMKGNPDF QTAFNLLLCL YDQGDKLRMK DCFSSMLGIE IPGYTENEEE
EMNQESAFND PLREEIKEKK RIAIDILVKS AKLIAPVIEE DIIDGYDWII ETLKESYFPE
VQAEVEICKA MAYLKSKNMD KSIETLKSFE RKDKIMMGRV ATNISFLYFL ENDFKNAEKY
ADVAINYDRF NPKALVNRGN CLLVKNEFLR SKEQYLEAIG VEADCIEALY NLAFVNKKLN
MFNEALQALE KLQTIISTPE VVYQMASIHE LMGQTKQALK WYQVLLTKVP TDPNILARVG
NIFAREDDET QALHYYSESY KYLPTNIETI GWLGIYYVKQ EYYERACHFF ERASQIQPKE
IKWRLMVASC YRRMGSYQKA LKIYEEIYQD EPRNVECLKF LTQLCKEMGL PYEQYASELR
KLEAEEYAVN YQIEPQGGYD PNNGGYDPYG TGQSGNQEID ITSQTRRGVV ARPQQQVQQQ
IQNEDDWGAD DLGDGLMPV
//
