GenomeNet

Database: UniProt
Entry: Q22C42_TETTS
LinkDB: Q22C42_TETTS
Original site: Q22C42_TETTS 
ID   Q22C42_TETTS            Unreviewed;      3401 AA.
AC   Q22C42;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   16-JAN-2019, entry version 68.
DE   SubName: Full=RIH domain protein {ECO:0000313|EMBL:EAR82870.2};
GN   ORFNames=TTHERM_01076970 {ECO:0000313|EMBL:EAR82870.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR82870.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; GG662686; EAR82870.2; -; Genomic_DNA.
DR   RefSeq; XP_001030533.2; XM_001030533.2.
DR   EnsemblProtists; EAR82870; EAR82870; TTHERM_01076970.
DR   GeneID; 7822847; -.
DR   KEGG; tet:TTHERM_01076970; -.
DR   InParanoid; Q22C42; -.
DR   KO; K04958; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   SMART; SM00472; MIR; 1.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2969   2988       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3000   3020       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3040   3065       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3085   3104       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3110   3138       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3158   3177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3239   3263       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      178    231       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      360    437       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      442    501       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       79     99       {ECO:0000256|SAM:Coils}.
FT   COILED      462    497       {ECO:0000256|SAM:Coils}.
FT   COILED      799    819       {ECO:0000256|SAM:Coils}.
FT   COILED     1163   1183       {ECO:0000256|SAM:Coils}.
FT   COILED     1878   1905       {ECO:0000256|SAM:Coils}.
FT   COILED     1959   1979       {ECO:0000256|SAM:Coils}.
FT   COILED     2044   2064       {ECO:0000256|SAM:Coils}.
FT   COILED     2426   2446       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3401 AA;  401455 MW;  85A6B6191D0C254C CRC64;
     MTEVDERILR YGQIILLRFF DDENGFISAD GHVKKHVQMK SYDSKYLAIK RSQQTEGVTK
     DDFSNCLFQV FPKVVNTQKS KIIKEIEVYK KQKQKEENKD ELTKEKLQMF NMLVEAKDNQ
     NKQKGKKDKD KEDKDKNAQN YFDEEDDKDQ FLKRISKHQV YLQNEYKYNV DTFENNKNQP
     VNYNQPFQLL HLNSSKFLSC NSVESKWEKE NYEISLEEFC TDSTLFKIIP AFKYQKDSSN
     AISEGDCIMI IRALPFNNKT IHLHCSMELM EMKKKSQIQK QLVHQTFQGS ASMMYKKQDV
     AKMQHQYEQK QESAQKNLKD DNQMSNKVQV KIQKREINGC LETATPLKFQ IYQEITDTKS
     KYLNCGDAIW LHHSEANSAL SVIRKERGTT RYTFTALNIE QWISQQNLEI FVAQNKESQS
     FEDYSGNTFG LWIIENVDFK KGGYVEYGIG YRLKHMPTGY YLTVIDENLI QMEQKLKQLE
     QEKIEQEKKK SQKHTKQINR SFYDDQSEKS EDDEEKHVDF IVEHSKSDIN QDSSGYLDYS
     SGDDSPTSQP EEQKSPRRRR KKKLNKEAEL IKQKQKMAKK WKLSLTKNAN DPFTLFQFFA
     LGTSPSIFEQ FVEPGNFIFI RNMESKQWID VINLLNSNQQ DNADIPAQMK NFQNQNQLST
     FDQNESVSAF SPLRAVLKND QAENQVFKVF SVSSNEVWEA KFVISCSNVL IKFLINQKRL
     NQQCEQGDEI SIRKAKEKIK ISRECINNLN NFCSNKLLNY QQEQKFGAPN ARRQRLLREQ
     YYIDFLVKIL EDLLPKNELE TWIEYKQIMD KERKELEEED QEDNSDDSDE YGNGLGGIKF
     GSKKKKSKAN KTSKLSNKKD HAFYLKEKVN MAKDIYLLLA SLCRNNEVNE EYTFKLIPFF
     QIHCKYIPEA IDCIISLTSN NEKILMTLSE NLKIDFDYEK KEEGQSFQGR QVKILINMYD
     QDNLQYQDQF EEKIPFRQHE KITTKPINLI VFFMNLIWDD NSKLNSNYLK FLRSICRIQN
     KAISLNQENI FKIFKKYSQK RNAIRYDQYF KSGSIKLPEL GRDPKQFEND VSEQLKFYSE
     LSYGRNFLWR KELIAHFSNY YLLQNIWSQG DLKDYPILRS CFCQLAMSLY IDHEPLQRQN
     LPNYCRLFER IGDETFEKIF DEEKNQENEI AMYKNLLNGL ENYLRGVSNQ IQDLIIIYKR
     QKDRTNREME FKMKKRGQSI LQDPLLLNSM ELLYLLIELN LFGGLNKTDS YKDFMPFLQN
     ILVYDLKNLE YFTACAYTLQ LQNQTRKEKK KDKNKDLLNI SQGFSTIKNI GKTLNKSIIG
     GGESDEIDEE IDYELDSQEL VNPLEQSKLY DNHIMRGQIK LHNKLEEMNY SDSIGYQTEI
     KVKLKVLDIL EYFMDLRHDY LMTNMLKFFK DNIASIGKDL NLEQAKNKIL QITKDHVKGF
     LPNIPLTGID SVDKIFQYKQ DGSFKLDFKI SLNKKKSKDL KDKFHSYITK KEYIHYQDFN
     NLLSAAIEQS DSKKQEDIYE NPIATLLPSL LSSFLIIYDE NLEKRILKIL IRMYNQRYDL
     LENISKLQII FDKQTYDLFN ALEDMNARLH KYVEQCEVWF TTFAQKVYKE HFISHLITLL
     DNLNNGFFKC YTTADGDIIL LEQSKKREHQ KVDKEKQKIF QYLKIHEPII ELLNEGMHHF
     DAFILKDSYP ADKKTYLIKL FELVYEFLIY FTQDCRENQA IIKDYIPMIC KYLKYDLGQT
     TLICSIYKDN IDLLTNIDKQ LIETFLELIE NEGRQIQFLD IFEIILKIKN KYIFDNQLLI
     LNTFLPQKEL TEKEYNLLYA NGSNQKSLSF YLEDVCKSLE KQKLDQKLKD VEYRDTYRDE
     PFQYHMKILN LLIQTSYISS TQNSKEEEEE QNNILSNQAQ GESQQQSKLK KGKTFKVNDY
     DLPLQDIDEL GDEDAEEEDQ FGEIEDEEQD GNNKKVSIKD KKKQKINAYM EKLKQFSKSD
     HILQEFKFNI LVTRLKRIFK VNQLLQMLQQ EDSYADWSKF SNEINQKPDG NQELKDTQGK
     RGLFQEALAD KEEIERKREI EEKKKKYLSQ HMYEDSEFQE NRKQFKKGMS LLKPHLLNFL
     RKVHIQSETV ISSVSEMIQN QKEIAYFLDK EGLKVNCIKE GVFSENYVEY IFDYLLPFLY
     DYHKKFIQRG PHNMHIQEDE ERKDEKSLEF VVDKILSKLP VFTPYLSNNQ KERTTLIIKA
     IKGLNTKVKF EPLLQINLSS KISSHIKSPT KGDKVNLFKD LLPSKGPSNI NIEEQADIPE
     RNDAASDNND DETKLLKGNT LNLKKKIKSK LGAISLTSQL VVESQSQQSQ LAERNWQIFK
     VILKEEEFVI EQVQKEKIAL AEAIVRVKKI IKKEYGKDLT LKPDMFKLIK KFIKFLLYAP
     EDPNNKETII SLISVLKEII DSKGIKDRSE DEIDEEKDNQ KREKIQNMFD QLGAMKMILM
     VLSQNNRHLD NELIIHYLSF ANTLLEGGNS QIQNTIYSFF MSYQKSEVIF SRFNSIIRKQ
     IRNIEHKSNI GTGDAIEMEE ENSQMIELLE RVLRFLQLCV EGHYIDLQNY LRKQDNSRNN
     YDMVQAVADL LKAYYYGDCT QKMYDNMIFC LDTLSEFVQG PCKENQDAVS DSKFFDIASD
     LFSKKPLSEE AKQKKRDKKK KDYHPEEWKK MNLIEQYRKS KDQPLTEWMK GRLQNKVLIL
     VLSLLESREV KSNCEIIKRI MRNLPLYVLQ RHLIKIYKKF NLLYENKLNR SSLSHMEHDP
     RKESDLHFFK KLHQEGKDID DYLECILQNG FQIYFLLSYY IESDSKLGGE MVKIYKNYEK
     KILNNDKNEL ESLLTGDNMV GQLISFARSL IESVYKYADA VKQKTVEAVK NQIKIADSDD
     KKSQAKQAAR MGILKKAMSF FASNSSHIDI VRNEMLELVY FIRLPATNCL PKEVKTEFHE
     KCDRSNIKTK QSELIKESDD IIEICKHEYN LQILFSSNKF LALFANYVKL WKDLSFYISL
     VLNFFIIFSF STSTYADFSI RIDDYNLFDS PNYTLDQTKR IFRILGIVMI VCSNFVLLFF
     LFKNVPLIFQ RIIKQGAQVK DHKNFLGKVY VVLFKFLQII YEFLQDFQVI YYIAYGALAI
     VGTVINPFFF TFHLSAILMR FQTLKNVIMS IYMPRKQLLL TFMLFIILEY CFSVWGYSMY
     YEDYDERCES LLYCFLTTFD QTFKPNGGVG GFLTSNPAQA NVTNNTTKYS MSRFIFDQLF
     QYVLLNIMIN IVVGIIIDTF GVLRETSNEQ QEDMLNFCYI CGIDRTTFDR KSDSGKGFIK
     HIKFNHHMWN YIHFITYLEW KDRNEYTGIE SYVDDLLKQN DTSWMPFKMA REILDGDSDD
     EEVDLSQLSQ IQKKQKNLLK ELSSLIEGVD DLAKDKKEKR K
//
DBGET integrated database retrieval system