ID Q22KS8_TETTS Unreviewed; 686 AA.
AC Q22KS8;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000313|EMBL:EAR85721.2};
GN ORFNames=TTHERM_00312010 {ECO:0000313|EMBL:EAR85721.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR85721.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662498; EAR85721.2; -; Genomic_DNA.
DR RefSeq; XP_001033384.2; XM_001033384.3.
DR AlphaFoldDB; Q22KS8; -.
DR STRING; 312017.Q22KS8; -.
DR EnsemblProtists; EAR85721; EAR85721; TTHERM_00312010.
DR GeneID; 7844710; -.
DR KEGG; tet:TTHERM_00312010; -.
DR eggNOG; KOG1868; Eukaryota.
DR HOGENOM; CLU_401450_0_0_1; -.
DR InParanoid; Q22KS8; -.
DR OMA; GFENSTH; -.
DR OrthoDB; 227085at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF104; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EAR85721.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 265..360
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 371..686
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 71..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 79182 MW; 8258F8752FC6C2F8 CRC64;
MGFFNKLFSC LSAGKQKEGH KGMKHQHSQA EQNRMQMLQN QQNLQIPPLE NIQGSNEERK
NEIILKGLSK QTQEVHIKSN ELNNTNSGES EKAKKSSNSQ LQSHSKIQDN YIDNSVNAAD
GDDKNNRNGN LNQSNYSKKN PSFSQQNSSQ VKKKNGQSSN QGQVSMNLEA QNISKVSQKE
ENQETNFNNN PGSKNNTESI STSQSQIRNK NYKQSNHIDN TSLDSTKVSL NGSTVTNKDD
ISNSQEEYAM IDNKIKWIKS LDIKKRAEEE EKIISYFIQN TTCLSQNVLS FQWANEFSEN
IKKKIILGNP INNQMLVDAN GNLKEGLQLN QDYMLVSDQV WYFLYQLYGG GPHIIHDNDP
SKLKKLLFRP YRLENNSNYC YMNACLQSIL SIGELNTYFF DKMYLEYKDQ ITKKPHKFTI
AYSDLLTRFQ KSNSNQIISP SLFKKYSQQN FDPNEQHDAQ EYLRFVLGEI QDELNFPLPN
KRPAEFKDSQ QASKFYFKYH TSIVDRLFCG QLISKVQCQK CKYISSTFDP FLDLSLPIES
KSLKDLNSCM DLFFKPEEID GEYKCEKCTK TSRAIKSCQL GNIPKYLVIH LKRFKMFPYK
TKIKQQISYP STLDISKYYA NSGNESTKYS LNGVIIHQGS ADIGHYVSFN KRNDNKWFYC
DDESIQECSN KDALDQEAYL LFYEKI
//
