ID Q22LP4_TETTS Unreviewed; 3999 AA.
AC Q22LP4;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Right-handed beta helix region protein {ECO:0000313|EMBL:EAR86222.2};
GN ORFNames=TTHERM_00701050 {ECO:0000313|EMBL:EAR86222.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR86222.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662861; EAR86222.2; -; Genomic_DNA.
DR RefSeq; XP_976817.2; XM_971724.2.
DR STRING; 312017.Q22LP4; -.
DR EnsemblProtists; EAR86222; EAR86222; TTHERM_00701050.
DR GeneID; 7837891; -.
DR KEGG; tet:TTHERM_00701050; -.
DR eggNOG; KOG4260; Eukaryota.
DR HOGENOM; CLU_227769_0_0_1; -.
DR InParanoid; Q22LP4; -.
DR OrthoDB; 197978at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR11319; G PROTEIN-COUPLED RECEPTOR-RELATED; 1.
DR PANTHER; PTHR11319:SF35; OUTER MEMBRANE PROTEIN PMPC-RELATED; 1.
DR SMART; SM00710; PbH1; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 516..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3479..3501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3533..3553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3594..3617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3682..3704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3763..3782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3794..3813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3819..3845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 3999 AA; 467671 MW; E71D710608A326A4 CRC64;
MTYVMDIDNL KIQNSQFSID SISFKPQITG VIRNSNFKKI QLLQGSVLNI LGGLITISNS
TFESIQSETS AAIYCSQTKS LLIQYSQFIN TSCKYQKSLQ KCLGGALYLQ QIKTIKIIFS
NYYNSFSSDY GGAIYINNQN NYFSQINNTI FNNCKVKNNS GGAIFIQQSK NISIYNSTFS
NNSALLERGG AIGLYYSDLI ELKNSIFLYN KAQIGGGIWY GPNNQTFLQD ELYFKNNLFG
KNEVFFYGED IGSYPRKIQR VTSKSEEITS NQINQIQSGN LISEEIYFTF YDEQQKPLNF
ITSEKYPQSL EVQNELISYF LKVQIDKNPM IQIKQGQTLE RRAELGVFQL QIQLLYKQNK
TQLIQIQSNP LLNEYQLIYS LVLNFRDCIR GEIQQSQNGF IQCNPCQEGK YSLIEPNKSS
IDNLVCQSCP SQAIQCLKDS IVLRDGFWRE SLFTDQIYSC QTDGCSETQL RVIDRCLEGY
IGPLCDSCDG SKQIWGDYYG KKGKYCILCK QLKYQYIYFT VFLICYSIYL TLCVGDLIDQ
KIFIIKLILF RKIDLLITSK SCSQGETVTF WIKIFVHYLQ ISSLIFSFGI QYPYELSAPV
NTFGDPTNFT LTSLDCLFPL SQNYPIWLHR LIIQITSLVI QYILVNVLYY FLYLTNSYNK
AYKKKFIKTC LKTSFVFFYL FYQPSITKII FSGIFCKQIG SQYRLISDLN QECYTDTHII
LVLSVILPLC LFWCLLIPLF LNIKLQSIKQ HVDQIKQIEQ VIIYGIIYQG YKIKCFNWEI
IKIFQKLILM IVINSNLSDI IKITFIIVIL LLYTVYLVIK QPHKNIKLMN CEKMMMVLLN
FNFLFLLMII KESNPYYYVL ILGYILIFLC NIIAVICFIY LLSNSMVIRL CDDYTSSTKV
KNALYKLSQS FPKLFRHLKF RKVNVYRIHK LWKLIKKFIK NENSSNPNKK DNIKQLIKEN
ITAQSYSLAE SALKNVNSVL IVRIAYYEFK GNSCARSCEV GYYESNYFRQ CKLCKVNNCK
ICNDAQICLE CKQGWVLDEK RNTCQNEKCI SEEGTYYQEE TDTCKYYCKE GYDENSMQCI
KFKKLGDYEA EMIRIDQQQG NIIQMQAIKI EDQNTVIAID LQRAVYYKYP ELIPYFEIAY
NQTAYFAHIR GNYILVIYSD QNKIARINAQ TKKIDYYQLG QCDNPLVQQN YLICQYIQYN
ALIMIDLDNP LFKIFQFQPQ ARIIQEVLSN ENNLRQAFNQ QTPAEIESQS NKEYKNQSVN
QVNKQNRNLQ DLPQNQDQLG CYINYPKQFD AQPKQITNVL KNRTIQIIQE YSKIEDTQHF
NFFILEEISM LLYFDKISQK LYSLDSKNVQ SIIMTIQLYN TSQVLCSQYF NNTIHLLLAD
QNYSNVGYYL TSTFDSGYYQ FNQANAIKIQ DVELGDLQNC LFLAQFQTLL LQGQNGYLRI
KTSEIQQISK KSAFYKNEFI ISNTNSYIFT FLLDKANYTI NIYEIDDSIF KIFNQFNFDV
QQYYFSDTPS KFTFLYDDLE KNIVLSYRNE MQLIRLLPKQ DQVSQVFSRY AGGKIRQNFG
QIITIFNLEI EDGICIIYQF GFNIIFGKTT TSSIARYLDF TIEIYDQKDN YLVLGSNLQK
KIVIFDIYLQ QFNELNYEIQ QFQKLFIAKS SEYLIVAISL MNGTFNLYTI NGKQSINGYS
LNYNLLQQGY TPTIQSFYNQ LYIISDQQTV LIYKLQDQLS FLTSFYYSQY FQVVGPNVIF
QFSKCKENSD TYLTVFNILN QSTYFILFQV EDISYQKIQV TQYLRYAKIL FQSGRYKVKI
FDMGNQSFIE KPPQTDLNNS LLVDRYIIYL LGQSCYIFDM QTLEETQVSF PTYPNIQNYF
MISNQPYFLV YFPNLEKSLV FNISNQQFQQ AVNVEQSQNS KFVIKNEEIL IFDQNKTQKI
IPYFSLALKQ VNRNNKCRQI NMVLVFLQLT VLLYNQRNGI SFDDKSNILV FQTVSQDTLN
FYLLNSDVLL SVQIEKYRYM PSFQFYNFEE YSLVLITMSA KEAYFINYEQ GIIFKFENGG
QKIKFSDGLF IQDKYIVTFE YQFIYKFQIQ QGDIKLIKQY QPSIDFLEIY NQYSNQLTLA
YNFESNQLIL VNLQKYIMSF DLDTFVNVCQ QQYQQVLGFV YFQEQNIVIS LKTSSFTILY
LNSCIVKSQN LMGITFTAQP QLNVQYNLNI FLIKTSDLLV LVSTNGLEVY QFSTLNYLIT
NNYKYDNKYT QIQSFILEDS NEIILTTTDN QIQIYDLATS LFYNPKFLDT SFENNFVYFN
ELNIVSYLNQ NSGNEYHIVD VQNYSYDIYK ISFRCLKVKN QNFNIFCLNE MSQIYKLNLA
SFKFDLIFNQ ISEQSITDIE VLSDDFLMIQ QKNRTFIIFQ ISTKKQSKET DLISSALKIS
MVNNLIGIQT RQKISIYFIG SGDSQQLNIQ QIYEQNNKMY IQSFTIIKTI NSYQLIYSTQ
ETTFIYDIFQ NYQIGTMKNA AQSKQRVFTD DKFIYIVGIS NLILYDQNTL QTINYYSVNQ
FVYSSIQNVI HVDEDYFILI LEQQLILAKI NLKCNNLIQT FSNLINAAIL QIEKTYNSQK
QLSAIYIYGH TDSNLFKLEV SKLDNNLNSR EVSLEVLYKE TQIQAQQMHF QKQTEVQKQN
KVVGSYILSF EKQEQQQIGD IPIYYNQIFT NYTLLQIQSA TSIVDKVVSL VINDNKFSQL
KFKRILFFNI ELYIQPSQEQ LILNPLQKVE KIIFDKVYLR FFDESQSLVI NDCKQLIWQE
VIIQNQTLRR KYIPLQIQNI DQIKIDQLFV DNIKTSSVND GIYFINITSI VIDRIIVNNS
SFSSNLLKFY NCSNILINEI IIKNTLITRG SMFYFEKIDI LNITKLNAQL DKTLNKLYKD
QIFDSQEKQN INSDDLKIYL LTLKGCFSNY LSNFQVDSQI NTGIIKSLYS LQDLKNPSFT
YLVVMKNITV TNFVFKQDYQ LFDLIGYIIV FDNLQIINSQ FMMDSISIRA SQKGVIQNSF
FKGINLFNGS IFSLQGPDLL FRNTTFQNIS SQSTAAIYCF QSNTLQIQQS KFIDIKCESQ
SLQQKCMGGS LNLQQINNLF INGYFDNSIS DNYGGAIYIN KQNDYSTQIQ SSIFNNCKAK
NGSGGAIYIQ ESENISIYNS TFSNNSALQE RGGALALFYS NLISMNSSTF IHNQAQIGGG
IWYGPFNQTL MKDLNLLTNN KFQENEGFFY GQDIGSQPQY IQRITKNFEQ IQNNQLEDIQ
SGNLMDQGVY FTFFDEQNKP FDFIKSEQHI QSLEVQNERL SYFMKVSTDQ NPHILIKIGQ
NLEKISQLGL FKLQISTSYS HSKEQKIQIK SNPLMNQREL FYNLTLKFRD CQRGEIQQSH
NGFIECNQCQ EGKYSLVEPG QINQNDLICQ SCPFQAIKCF KDVIILKDGY WRENNLTDQI
YQCQSHGCSE TQNGVQDRCL EGYIGPLCDT CDTSKQVWGD YYGKKDSYCF KCKEIKYQYI
FFSVILLVYS IYLVICIGDL IEQKVFIIKL LLFKQIDLLM TSKSSSQGET VTLWFKIFIH
YIQITSLIFS FQIKQPYELS VPVKAFGDPT SLTITSMDCL IHTSQNYPFW IHRLVVQIIN
FAIQYIVVMA FYYFFYLRGS YHANLTKKLW NTGLQTTFVF FYLFYWPSIA KLILSGYFCR
QIGEKYYLIQ DLNQQCFTSS HIILVLSFVT PLCLLWCLLI PFYINKQLQK IIQYVDKIKN
IQQIIVYGIF YQGYRIQCYN WEIIKIFQKF ILMIVINSNF SDIIKIALII VVLLLYTIFL
SVKKPHKNIK LMNCEKIMVA ILNFNFLFLL LILNESDPSY AVLVTGYILI IICNVIAISS
FVLLLSNSLV IRLNDENSTS TKIKKLLYRL WKAFPQALKF IKFRKVNQYK THKHWRHIKN
FVYKQNTGDS LSKSNILIVN YKNNKKPILS SLNNLKSDRM DQLDQDQQNF IFSSEQIDER
VENMATKGNE TSYKGGLGSQ KEIQLTTLNQ IFNRDKMQK
//
