ID Q22N21_TETTS Unreviewed; 332 AA.
AC Q22N21;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Zinc-binding dehydrogenase family oxidoreductase {ECO:0000313|EMBL:EAR86299.2};
GN ORFNames=TTHERM_00028530 {ECO:0000313|EMBL:EAR86299.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR86299.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662720; EAR86299.2; -; Genomic_DNA.
DR RefSeq; XP_976849.2; XM_971756.3.
DR AlphaFoldDB; Q22N21; -.
DR STRING; 312017.Q22N21; -.
DR EnsemblProtists; EAR86299; EAR86299; TTHERM_00028530.
DR GeneID; 7842247; -.
DR KEGG; tet:TTHERM_00028530; -.
DR eggNOG; KOG1198; Eukaryota.
DR HOGENOM; CLU_026673_3_4_1; -.
DR InParanoid; Q22N21; -.
DR OMA; DWSWEYA; -.
DR OrthoDB; 2598390at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd05276; p53_inducible_oxidoreductase; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR014189; Quinone_OxRdtase_PIG3.
DR PANTHER; PTHR48106:SF8; QUINONE OXIDOREDUCTASE PIG3; 1.
DR PANTHER; PTHR48106; QUINONE OXIDOREDUCTASE PIG3-RELATED; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 10..327
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 332 AA; 36707 MW; EA7932CCC45EABF0 CRC64;
MKHIYQDQPG DVNVLKIKES PLPQLKQDEV LMKISYTAIN RAEVLQRQGK VYPSPGHSPI
IGLEASGYVV DHLGKELYPA IGLFSGGTYA QYAAIHKNHV FELPKGLTLE QGAAIPEAWI
TAYQLIKYIG QVQKNDYVMI YAAASGVGTA AIQLAKYFGA HAIASSSSED KLKICKELGA
ELCINYKTCE NQDEEILKFT NGKGVNLVLD CVGAQNFKLT DKIIGVDGKW ILYGSLGGTN
IEKFDLGSLM RRRASLITTL LKTRSDEYKS DLISNFKKDT IEGFCSGQLK PIIDRVINIT
WDEEGLKGWR DAHTTMESNE NIGKIVVAYP KI
//
