ID   Q22N34_TETTS            Unreviewed;      1753 AA.
AC   Q22N34;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=REJ domain protein {ECO:0000313|EMBL:EAR86698.3};
GN   ORFNames=TTHERM_01237400 {ECO:0000313|EMBL:EAR86698.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR86698.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662858; EAR86698.3; -; Genomic_DNA.
DR   RefSeq; XP_977293.3; XM_972200.3.
DR   EnsemblProtists; EAR86698; EAR86698; TTHERM_01237400.
DR   GeneID; 7829094; -.
DR   KEGG; tet:TTHERM_01237400; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   HOGENOM; CLU_001625_1_0_1; -.
DR   InParanoid; Q22N34; -.
DR   OrthoDB; 5471657at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00064; FU; 3.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002859; PKD/REJ-like.
DR   PANTHER; PTHR15332:SF175; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE; 1.
DR   PANTHER; PTHR15332; UNCHARACTERIZED; 1.
DR   Pfam; PF02010; REJ; 1.
DR   SMART; SM00261; FU; 7.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1542..1568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          779..1208
FT                   /note="PKD/REJ-like"
FT                   /evidence="ECO:0000259|Pfam:PF02010"
FT   COILED          1577..1622
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1753 AA;  200320 MW;  C81AB7E5D974C496 CRC64;
     MEKRDYNFFN NQTVLKYLYA DSGDCLEQVN FLNFNPKFSY CIINYKKPST QTDIDNMKQY
     FSDMNCLNSI SFYWDLLSGT NCISNRDITI QYTPQNPKTK IYSFNLQYQL FTGMTSKPNL
     LSKIEINQVS QLSQLGYIIN DQRSSYNSNS MIKTQQNVDS LTIKITPFYN YIGQNYQIYF
     KYLYLIVQLC QANCDQCDYN QVCLQCSSGY VYKLSTNKCL SSCDSNEFVN NLNQCQLCDN
     NCASCQGPSS NNCLSCKPGL YYDQTTRKCF ICDSNCKTCD GPNSNNCLSC NIGLYYNQPT
     KQCLCDSTCK TCDGPSSNNC LSCNIGLYYN QPTKQCLCDS SCKTCDGPSS NNCLSCNIGL
     YYNQPTKQCL CDSTCKTCDG PSQINCLSCN SGLYYQQAAK QCVKSCNQNQ FPNSLLQCQS
     CDSSCASCDG KDSNNCLTCY TNSFLYNKNC VSLCPNGFQR NFIALTCDSC QNYWSLQCNP
     CNPTCQLCDQ SQILNKQCKT CYDETRQLSN NACVCRNQHD QRNIFYQCSY QNIAVVDARL
     SAISPLLTID LGSPLVNIIS NTPQSLCSQV FDSATLDMLG LDSSCQISGN QILVQLSSSS
     TIMENNSINI LPNKLQFIDY SSNFINKFYR NITFQDPPGI PQLQFSYNHI ENSCNSINIT
     LNNLQNDAGR QFMSLNWTLN QIAGPISKEQ QETIKDLLLK ASQNKSTSLI IDPKFIPPNI
     NITISFSYLL KVNSTGTQMF TIIYQKQKFI RVNYQQSLYP PIYRSMSLSF YFQFYIEICE
     LGQITYFNEP VDLQLVSNQL QKQTLSQYNQ SSFQYDILPY SLASNQIFNI SLILNLSSDS
     KISAIQNISV DIQITDLYLQ IIGGSSLVLG YQNKMVLNTD SRDYEIQDQN SLQNINFSWK
     CSSLTTNDHI CYDYQNKKIQ LQQGASSITF PAKTLQPYTI IQLTVVGQKD SRQSNYTTTC
     IFTELDIPPL KIIQTVTSIN RKINLNDDLN FQIVYGDNIS SDYLSYAGAI LYDNDPVAAI
     KFDYFQIRFR IWNYFQNIGP SKPTLQIRFS VYNPLFVMPS SSVISLQINI PPQKCVLNIN
     PLQGIALQTI FQIQLLNCKD EDLPLTYQFF YYNSADDADQ ELVSPWNILR RQIQDQAINN
     SIQTILPTGN LVVMVQVMDS YLGVYNTSSI VQVQAQNKSS DEYYKLVNQL TSQALQNSNI
     QVTNQLVTLS IIAEDISKSN QLQQQLNDQA SILIQNIYQL SLQIPKFSLL STFANKVTAQ
     LSQLLFNSSQ QNNFATQKIK IFGQLQTILQ NTNSSIQSSN LSHLQQNNDI QIQNVVDSFK
     ILNSSVTLHT NNSQEDFQSY DKISSQIGNL LNNISLPNQG PIILNGDLSI LLSDKVTQKN
     LFKYVLTVDE NNSVNQTSIF SISRNNYKQN IYENTSEFLA YTQQFKNISQ NFTYSKNEVI
     SPQIYNSSSQ TTLNQSTIVY QFNNTNSSKL YNMTCLQQNN ISWSKQNCNI NKITQNNYIC
     LCESQKPTTI IEDIDDLFLK NKNLQTAFGE QGLLNIASFE NFYLYIVFWL LLFFTLIQIF
     LFIIGKFLDK YSVKIRYQKV HNQEINNQQQ NEQLQEQGQQ QQQQQQQQQQ QQQQQMDENN
     QNICENSKMI NNDIIFQHSP FTHQLKSNQN IQPEIEQNQQ VLSPLDQNIG NRKRKRQKFL
     NLQTQQTEKN LFQEQNIETN SEKAESNQLQ IIKQQSSSNS VEKIKTQTCS ETQIKQVLDE
     EEIQQQQPQL TAH
//