ID Q22RH8_TETTS Unreviewed; 1845 AA.
AC Q22RH8;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=NLI interacting factor-like phosphatase family protein {ECO:0000313|EMBL:EAR88144.2};
GN ORFNames=TTHERM_00016090 {ECO:0000313|EMBL:EAR88144.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR88144.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662845; EAR88144.2; -; Genomic_DNA.
DR RefSeq; XP_001008389.2; XM_001008389.2.
DR STRING; 312017.Q22RH8; -.
DR EnsemblProtists; EAR88144; EAR88144; TTHERM_00016090.
DR GeneID; 7826840; -.
DR KEGG; tet:TTHERM_00016090; -.
DR eggNOG; KOG1605; Eukaryota.
DR HOGENOM; CLU_235220_0_0_1; -.
DR InParanoid; Q22RH8; -.
DR OrthoDB; 11362at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR CDD; cd07521; HAD_FCP1-like; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR004274; FCP1_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR PANTHER; PTHR12210; DULLARD PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR12210:SF179; FCP1 HOMOLOGY DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03031; NIF; 1.
DR SMART; SM00577; CPDc; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS50969; FCP1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 1655..1797
FT /note="FCP1 homology"
FT /evidence="ECO:0000259|PROSITE:PS50969"
FT REGION 326..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 460..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1141..1168
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1527..1555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1569..1605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1845 AA; 211794 MW; C4081F3F5848815C CRC64;
MSSYLQSTQK KFINPSENKH YLGYNPAKPC LTERTAPYSN PKGNASLTYN SVTPKRAGIQ
EQGKIGLSNF LSPRSDNYQN IMPNQLNQTY ANGTNQSANN GYFVGQNMKQ TGYRTVFQED
IPQATNQSYN YQSNNPISHQ NFNIYSRSTT NITPNKSSEN INIDRSLESS LERTRVTNDK
QGDDIKKKKN GNNINATNQE ILNKLKQLSK NPNANFTQNA GGAYNNAQTS SQSAASQNLF
KQSSLAQTNQ TLLTSNIKNS NNNNNNQILN ANNNLPSSLN YGKQNINKNF QQQDNQYNLS
SQQNNPGVNS INSILSTQNL NNVLNNTNSK RSVTPNGGVM GNHNSNAGNN SNQIQDLFNR
TQLSNNLNAH NNNSSAKQHA ISPIQQQMNS ILQKVATSNA TGLGPQLEQQ RQSVPILQSQ
LQQQQQQFFN QSSQTKQNIQ AKQQGNINLD RRFTPQYIPQ EAFNQINEQL NLKALNLEEQ
LNLKNAQQNF NPYSSTPNQK IQQQLQQTVQ KRPNVNSNTN LLSKLSAPNS NNNTNNNFFK
MFNQQQRVSS PNINNANNQN NMMIRTSKQN QDDLDDQTVR LLTGDESLNA IINKLDQSGQ
YLNLDSNNGY LNQAKGVSSS NQLPHSKNTS SNQVTNLTDN TNNNINNHHI YTNSSSMNSY
NESQNELSQE NLNQYLINNN NNNTGVNSQN NLSRDNQSSN RQLVNNIQNK QEHEKLMMKL
LQEKLGENCS QYLMNQQNNQ QQISQKQYHS QGLPNSAQMQ QLQLQQQLDL AQFQENETPR
KVNKSVPMAT TANQGQHYKV SDIMKEQTKK NNSSSNQNRG GLQKQIMEQI LQSKIGQSGL
SNQQSVLPMT PNQILKQQQQ QANMLLESAN QIENEIQQIW LQQQQQQQQN QLPDQISNYQ
ISAPINALQQ QSQGIPLVDY QVVEDYESNE GNSNNLSSNK LVGYQQEIMN TQLQQPQLNE
QEYSSADLNQ ISNQQQQIPQ PFSNNQNAFQ NQNNTNSTEP IDFDEFQNYN QSPNVQFGQQ
QYQIESEEQQ QKQGVDQQQQ FLQQLQQYQQ QQQQFLQKNS NNPLTSALLQ NQQQIYQLQQ
QQQFQQQQQQ HLQYMQQQQY FNNPNDIAKL AQQKLLSQQQ IYANQLKSQS NSMNQGSAAL
QTSASQLLQI ANQQKQQLQQ QLLQNNLMMQ QNNIQQQGLS KQNLGQLNNL QIQQFQNQNI
QQNVNNNANQ GEIILGCTDG TKQLNLNDES ISSTSSSKSQ NNILNKQQPN LQQVVAQQEV
PKIEVEKLKQ ILSISLQVEE CLFELLQNRE FDYQAKYLIK YYQLMQDIAS LQSLPISKIQ
MKEIQRSINM QIVLIQIIIY EHIVVIKQLR ESVRGTVSMN ENLQNILNSF QYVHSSFILI
LILFEQAVQY LKDQGEKQLE QLDLSGISNV IKERTKKRKM GFLIKNQDKI SILKKFNDIL
QPLIQIVIEG QIELQEENRN SHTLYEDLYQ IQENIPNLQI QQILDFSSKL SNENVQFMKD
EVSRLQIVQE RKSIQKQLEL EFQNHQSESD NKSSNQNLNS SSQQQNQAKQ SQKQAESQKS
KQEKSELNDN SQKQQNQSQN QDEKQQQQQK RQEASQQSDN NQKPQNQQIE EDDLEDLSYK
NPNSKSKPDQ EENNSSSYQE SSIIGTVQPP YLKDSPQKPY TLVIDLDETL VHYQELDDGG
QFLVRPYAET FLEEMSEYYE IIIFTAALQD YADFILDIID SKKSISYKLY RQHTVTYQNS
YIKDLSRIGR DLNKIIIIDN LPENFKLQPE NGIYIQSWYG ESEDRALYDL TPLLKQIVRK
KFRTVQSALK QFRDKIETNL KKGMSEPHLN LSLEIFSGDE DDQQR
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