ID Q22S33_TETTS Unreviewed; 4967 AA.
AC Q22S33;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=AAA domain, dynein subfamily protein {ECO:0000313|EMBL:EAR87939.2};
GN ORFNames=TTHERM_00010990 {ECO:0000313|EMBL:EAR87939.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR87939.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662845; EAR87939.2; -; Genomic_DNA.
DR RefSeq; XP_001008184.2; XM_001008184.2.
DR STRING; 312017.Q22S33; -.
DR EnsemblProtists; EAR87939; EAR87939; TTHERM_00010990.
DR GeneID; 7831414; -.
DR KEGG; tet:TTHERM_00010990; -.
DR eggNOG; ENOG502QQ65; Eukaryota.
DR HOGENOM; CLU_223585_0_0_1; -.
DR InParanoid; Q22S33; -.
DR OrthoDB; 181055at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031248; RNF213.
DR PANTHER; PTHR22605:SF1; RZ-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22605; UNCHARACTERIZED; 1.
DR Pfam; PF07728; AAA_5; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 2066..2332
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2436..2600
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 172..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3517..3554
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4909..4936
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 172..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4967 AA; 589620 MW; 7BC81F148F74BB9E CRC64;
MDQQLDLDTN RDSVKDSKIK EDFDILTLLN QKQVVEWIKQ YVCKALEQAP QESNLKDLND
KVLEKDIKIS RPIHRKLKLE AFKAILSQSF IKKLPQKPQK EWNTEQLLIW INSCLSDLKL
STEQINNIIS QQMNEQDIDD INALTLREVI NIDQQQQISL ILESDKTLQQ QSNLDKESKQ
QSINQVNNIE KKDDNTTESQ EFNQNNLKAT NQDQVNHENK SDLLIKQNQN ETQTNKEHKA
KNQQYHDAKS NQKKQDTQKR VHKEEQNATK KYKSYIKDQE NITFSHFLLL NEEQIAMYNQ
NCAQNEKTFT FYCLFSQFKK NDLLKLVLFK DKYFFNVRTQ EILLEKQMEL IPSTNIYYTH
INLQDQQSIK YRYQLETYSS EKLKFVESDF IERSSHLLNQ IERIIFDTPY RFGNQFDQSR
YMLQSYTFLY AQNCDIVSAQ FFQQLLKFIK CVVANKFDQQ SLIILQANNE DFNRISQLKK
IIYTGALQQF KILKKFKINL DYQISIQEAQ AQYQEFKNLP EEMKKMFGLG FSHLVKKDQL
LEALSLPKEM RSYIEESTWN FQIYALPNDN IIEQINFESN LYQEFIEYFQ AQTFLIQKQL
ILCEEIRLIV LQNENFISLS IKILEKNADE EEAAAIQLED KIKIVIDVLE NFKRQPKSVF
KNQLTKLLSM LNNEMLSNQQ IGNKLKSVIQ FVGYQECYEF ISSIKFNLKN EMLEVALIQS
MIAILKDANL NTNENSMHFQ QIVNSSFFQI LNQRSQNDLL VKLFDMITSL LTQNEEKFKL
IDDQNFLDNL CILKKFDLIT KCMIPNQILE NINTILTNFR QKQIKLQDLR RLSQVNYKKL
LTFLDVLNLQ QDDNSLEQSL KQIIQYDNYM IGLKQFAYFM ENLEIPNYKQ MGQQVKDYFE
KSQNMYLEEF TANKKSEKQY KCLDFLYKFN HIPLVYNFIK TNLVSLNEQI RPKSDLELDQ
KIIELIQEIR NHLIKINCYK EENDSLTIKE AFRFWGYTFK DNYSQNKNDI FKYIYDLQIY
FNQNDQLNLQ IKPENDFISE IIDTSQFQQN KCIIEQIYNL FGIIEFQQIQ KYKENYQELQ
KLIYQIQEFD ESAKQEEQLF KIFAAQVCYY LNRILQFLPN DCKSDIFNFL SVVNQTKKLI
EYLNQLDRDK IQLEDLVDVI DDTSMETDAL VQEMMNVRNA LQFVRQGEDD KENLIKCFVS
RNQKYKLNLK KNYKLESTIN RCIDNLDDIS LKIQSQSDKS TQILQTIKNL EKSITISIER
LENLSESQLL LTTQREINQN LTDHAFNFDD FNLLCNRFKL IISNKKYTQQ QQPKEQQISQ
NSKENIYNNL ILVLQLSEQI RLTLDNLKNL GCTDIADARY LEKNSLNLII PQLSEDLEQF
KQKNQNHIIN LTLARQKYLS LNFYPPYSFE LVLKLKDCLN DQNQSKFYLN QLSKLTLFID
DSKQPNLEEF KKFLQEQQVK NDIQGMDLYG HALDILLNLP KVEYVEKKPQ QLDKITQGFQ
IECRRIKSHS LLLKSIITIF LAHNQKPTSW QIFFCSPKTH ILDLEQFAYL AKNSQKNETY
KNKNPLFLIC QFENLSITIQ RQFIDKLTEM YEEKEKINLL IIYVGNFEDE NSMHILQQFK
YAFQVDSQLM NYDLVQYTNI ESLSKISLHL SKYSGFGKTF QIKKRCQQNN QKLIEIPIYG
ETTKLELVSL IQKKLEVIES NQASLYRLHL NLYDLKSDEI HSILFQLLIL RKLNYSSSYF
AQIPPQMEIE IEIQNTFLDV LENKVQYLKD YIHSNNIFKQ ELRTIHIQQP VAKSIYGADL
DMLEVIDNPN IKYEDIQLSL QYLRNASKIA SFQIENFENE AQLRQYLQKN QVDKKEAIQL
IKDHFLYQVE DNFSFYHIIC ILKFFCKQVV LFHKTIYLNL DNLNYQQINT SLREKVFQGI
IKTSVPYSCQ IMSNNFLTKE QEAKKENLPY FETLEQRNKN IKGWDDNLDH SNDFFLTISQ
SGSILPIFQK IQSVPKYLLD YCNQINSKIQ DWNDLQNIRD SVLINLCTSA RNIKRVEEEI
ASKYSDIAIT KTIARKICFL YIKINSDIPT LIMGETGVGK TIIVKYLSSL ISSVVFTLDV
HAGLTQNEII KWVQVLIQLS YLDIDQCQKR IEELDQNLLL DPENEDLNNE KKQVTQFYEF
KVNQQKERKD DLNDQKVILF FDEINTNQNI DGILKELLVE KKIQGEPLPD NFVPIAAANP
YKFKTARDQQ ENTDSLKISS CENQQTSKLV YHVYPLAESM NTFIWQFGEL LPEDEAKIVS
QMVLNTAVEN NFITNFQQTL IQTITGCQEF SRKKQSIRSV SLRDVSRFLK IFKYFNADPA
WNKDLSDSLL LSVFFSYYCR FNNTNLRDEL CTYLENEKKV TYSEHRKPFV HNVKKIVNEQ
MDLLQGILQY GDFYKSIAFT STLKENLFML LISVLNNIPI IMVGPPGSSK TLCTRLLYNS
MKGSKSEIKF FKKLPNLIYK TYQCSTLSTS ESIQKAFKQA KKLDNTIKKS SNETQDGARN
IVALILDEIG LAEASKSNPL KVLHRLLEYQ QNVPMIGLSN WSLDASKMNR VVFSNRPKLS
EVELIEAAIA LQKRINPNSE YCLNVVINLA KDSFRYFSQD NNKTYFHGTR DFYNCVTFIC
NNLKNHNEHE QDKTQKILLA GILRNFGGQI DINETLDHFK LSLGQSGQQL YDFNLNLFNP
TELIKMNIDD KNYRNLMIIA KKPDHALQYT ERLCKDRLYK VFQGSDLQDD FTEYNSLKML
NEIITCMEEG YLVIMYSLES LYQSFYDLFN QNYVELGAKN FCRIAIGSDS IRSQVHQNFK
VIIIAQSDDV YDQRQNYDPP LLNRFEKQYL ELKFLLKKNE VSINKELNQF VQSNTEIKSD
RRLLAHKIQW NFGVQDMFPI IQSDNLDEFL FSLTLKNNDE NDDVKRVIKS QYELVDLANF
SGVVRAHYLK RLDTKLYNYY FNSLNHFNFR DILDKLTNQK KHQLILNNNI DGEPNYFEED
KNDMSSNYLE NGEIEQVNRL SENLIIYTTE YKYQNDSNQS FKQKTFMELE VKWLENIENL
KQQVKQFFGS EVFVNLIIIS SVSDSITKLL YIKRILQEER KIYEQNQMSE YIEQSPKNLI
LVIQLINQHT KFVGISFDKF WQQIYLEDTS IPQNNYDNLQ SYLQPISVVL KNFENGIYHQ
IQQDCFPKIL GNFNFEKQDL TQESIKQRLQ KYIKIFQLES DCNLNLFVIN KIIEKIEKKC
CVISNIYGKC EWYHLVSLKD KENRNNNKFI TSLKQFIFQE SLAILTKMLY LAEKNNIISS
FMCDQFNFQQ QDINQIFQIL IQKYDELSEE DKFCDQIQII QYPFFNNIKS SIDQFKQIYL
EITNDIFQIE DRKQIRISGG SQEEEQNTDD QNNIESNEKQ IQYQQKKRRQ NIKEISKILI
NLTQFNDPIL RYISSINPLL YFENLHNEIE YQWTESNIVK RITRKIIQVL GEEKVIESFH
SILWINEQIF IELCPVWILC EEECSKSLFE EIYQQFEQRL EQILLDHIEE IEKYNNKNQN
NDEEKNNYDD NDEEQEGLNI LEQIWSEIFT FSSNILELFV IPNDEDKIQN YQQQIYKLGI
LKKCIYTVYN CSSSYELLPE QMMQQMSKFN FILKLSECFT QGQDFLSLIQ QQIQSQNNGF
KFLNIQNYQK IKDNFIQICD KQKVNELVLR LIWQLLKCDH FEEEFENFDD EILKDIILSL
SNLLITINYE NISKNQEESH YYILSKRILQ IIIQKMYQNF DENEEEQIEN LLEPKRNLSF
QKMQKIFEES GIQKIDPICS LIADIIQEYN YYTPEKFLNY IGKDEDDIEE TKVERMGKFL
QRLNQNSQNK VLINIIEFKI SQQLCQTVCK FINEAYLFNK KEEQIYQKVK MTIEQDYNQD
RVKKNRMIEM LNKTLLVTIN QNEQINPILP IILVKIFKNI YNFKSVSVLS PYLEAFKNEM
FLESNQNENI WDNNLESLAA EFNNDIKINK KLTNLKKEIE NQLHNLPILQ YNLTKLISQI
IIDKNKQEID LMIEILNELN LKFIDTNLIT EIYRLYLDLL QENQYFSIEL QQLFVINLVM
TTFLNEDSFI SKMYKGKINI ETTFIPFMVD SDEILNIQDE LKNYSAIRRY QCKNCIKQQI
KPFIYTITPC CLPSNLIQCP SCKIQPKLED HYSLDIEPPP TAFGKQEPIF VKKIGDYPDY
SYYYNRPNFP YTCDVQTIDN FLQSRGRVDP GFQQSFSLIQ IKQIRNLVEK EQILLGRIFM
LSIICFYCHL IKKQKGQDEV NKQLGLSSPN DVFKLIYSNA QVGQIQQISS WDLLVQATQT
NPQNLLIYFI VKIVKNFINK QSSWDFTDKL NFSLDESRIQ FESEFVDKIL ESKEIVNIKK
FTQQLQQKRL KNIILNCSID QLPDQFQYLK QYKHLLRLNP IIQQDNFQRF ITFESEGIQS
KFFQRLIYYK EQIHIYSQIQ PIQNFIKIFN QKMFGKITRK ESAEIQLHQF VKSNHLEKEF
EQFKQSWNYV QQQIHNNKIQ IGVDCATIEL DEVESELQKI DILCYSEDKA SRGYPLYLLI
NYFQVQYNNF LEMLEKDFGQ LFSKFQSKKF IIMNKMNFLP PYIFSIGEEN QFANQFFNDY
TEMQSSYNPY LEYERQEIYD LNELTCEFIE DYYQNVTKME QTSKQDIERV QLTNFRFKGD
QNTINLVREI SARVNQEVYP QIQNNPKMPL LFIDLQNNET CMRLIDILKT VMQIITKING
SQRFQDQIDL LQILDYFEIQ ASDINFKKEK IKLCHLLSIY ELAERISFER LFQDVNPQFM
LELQKSQKDA LKLFCDQQPH IELDIFQQAI GRMIVRILCQ QSIQMSSGLE LFQLLEGCEE
FVDFWGMEHK IYHEKQIMNS DLNKKYSIFT SQSPDVIVLG QAYNMFREIQ AIKDQKQQQE
IEKINIQLKR EQIDEEMIQK ELIQDNKFLV NDDKKKKFQL KNKKSFR
//