ID Q22SB7_TETTS Unreviewed; 578 AA.
AC Q22SB7;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=CAF1 family ribonuclease {ECO:0000313|EMBL:EAR87855.1};
GN ORFNames=TTHERM_00006190 {ECO:0000313|EMBL:EAR87855.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR87855.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR EMBL; GG662845; EAR87855.1; -; Genomic_DNA.
DR RefSeq; XP_001008100.1; XM_001008100.1.
DR AlphaFoldDB; Q22SB7; -.
DR STRING; 312017.Q22SB7; -.
DR EnsemblProtists; EAR87855; EAR87855; TTHERM_00006190.
DR GeneID; 7832656; -.
DR KEGG; tet:TTHERM_00006190; -.
DR eggNOG; KOG1990; Eukaryota.
DR HOGENOM; CLU_018030_1_1_1; -.
DR InParanoid; Q22SB7; -.
DR OMA; SCDRASC; -.
DR OrthoDB; 180908at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF49; POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1; 1.
DR Pfam; PF04857; CAF1; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT REGION 233..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 67724 MW; 11AC68B7230AB84D CRC64;
MDIDRNNFKD NYQKIIQLIQ SCDFISFDCE FSGLATERFS KIRKYDSDED IYQKLKHTVQ
NYHLLQIGLC IYTFCKVQKK YIAYPYNIYL NPVYTTSSES IKKQIIQLEC FNFMAVNGLD
FNKLYSSGLS YIKLAQKEKI LENSKYQQNH GIALSKASRD ALEQIVKQIQ EYDQDNNNTK
DVTIECKSQY LCTKILKKQI GQAIYSCQNV NVDKGQTNTQ LIIRKKKPTQ NQYFKNKQAQ
DIDDDENNNN NGTEEIKQNG DGDDVSNPSH SSSEIDLLGF SLIVEAIVNS KRPIIGHYMG
YDLFYFYDHF IDVLPNTFVE FVEKVNKYFP YVIDTKVLAR KLQNKVKKLP LHLEGLYRAV
AKDEKCLKKH HNTVLTNDPQ FSKYTKEGQL HEAGFDSYIT GASFIGMCYF EKFEQEKEKQ
LKDVPQRTKK GKVVQEYQDK HDQILKQVME TFIDPNFAKE HLNHIFLQGG TFYFNHEFQV
ARDSFDINHN KEFLNNTLFI KFDPQISFQN LADHFSQFGD AEISIVDTNL AYVEYEQFEL
FEGIEDKLDH IIPLLKNDKI EISKYVDRKR FTAFSYFN
//
