ID Q22TJ5_TETTS Unreviewed; 354 AA.
AC Q22TJ5;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Zinc finger, C3HC4 type (RING finger) protein {ECO:0000313|EMBL:EAR88443.3};
GN ORFNames=TTHERM_00170280 {ECO:0000313|EMBL:EAR88443.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR88443.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662840; EAR88443.3; -; Genomic_DNA.
DR RefSeq; XP_001008688.3; XM_001008688.3.
DR AlphaFoldDB; Q22TJ5; -.
DR STRING; 312017.Q22TJ5; -.
DR EnsemblProtists; EAR88443; EAR88443; TTHERM_00170280.
DR GeneID; 7836409; -.
DR KEGG; tet:TTHERM_00170280; -.
DR HOGENOM; CLU_1079598_0_0_1; -.
DR InParanoid; Q22TJ5; -.
DR OrthoDB; 53998at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45977:SF4; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45977; TARGET OF ERK KINASE MPK-1; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 168..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 284..327
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 354 AA; 40785 MW; 3B2CBC015F0A6A2B CRC64;
MSHFCIYMQS APQNNDNIHI TNLPQSSNDQ SAQVEDTPQQ KKMKQNILIN KAILFLDAVK
VLMFALALRY TEADINGDIL NLFNWCKQMA ILALLEGCLK TWVIRNETIQ MEGLNKKKQQ
SLQLLDETLT AALTQPTTVE SADFDEIEFL QLFTDSSVQK TKKYLKQIFF SIENILTILI
NLTHIILFIL GNLVIYDKTQ LNQTFIYKTA SVYLLIGFLT FCIPIMILVA FLISIPILLF
GYIFSIRNII NLSQQKDELK QNKLIKAENV TQDNILTTFY KKDCSICLSM YEVGDNVVFL
PCNKNHNFHD ECIQRWLKVN NSCPVCRQNV NDQGFELQSI QNNTWVGLES HLYL
//
