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Database: UniProt
Entry: Q22WV2_TETTS
LinkDB: Q22WV2_TETTS
Original site: Q22WV2_TETTS 
ID   Q22WV2_TETTS            Unreviewed;       434 AA.
AC   Q22WV2;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   24-JAN-2024, entry version 79.
DE   SubName: Full=Folylpolyglutamate synthase/dihydrofolate synthase, putative {ECO:0000313|EMBL:EAR89761.3};
GN   ORFNames=TTHERM_01332110 {ECO:0000313|EMBL:EAR89761.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR89761.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SIMILARITY: Belongs to the folylpolyglutamate synthase family.
CC       {ECO:0000256|ARBA:ARBA00008276}.
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DR   EMBL; GG662811; EAR89761.3; -; Genomic_DNA.
DR   RefSeq; XP_001010006.3; XM_001010006.3.
DR   AlphaFoldDB; Q22WV2; -.
DR   STRING; 312017.Q22WV2; -.
DR   EnsemblProtists; EAR89761; EAR89761; TTHERM_01332110.
DR   GeneID; 7844397; -.
DR   KEGG; tet:TTHERM_01332110; -.
DR   eggNOG; KOG2525; Eukaryota.
DR   HOGENOM; CLU_015869_1_1_1; -.
DR   InParanoid; Q22WV2; -.
DR   OrthoDB; 7073at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IEA:InterPro.
DR   Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR   Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR   InterPro; IPR001645; Folylpolyglutamate_synth.
DR   InterPro; IPR018109; Folylpolyglutamate_synth_CS.
DR   InterPro; IPR036565; Mur-like_cat_sf.
DR   InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   NCBIfam; TIGR01499; folC; 1.
DR   PANTHER; PTHR11136:SF0; DIHYDROFOLATE SYNTHETASE-RELATED; 1.
DR   PANTHER; PTHR11136; FOLYLPOLYGLUTAMATE SYNTHASE-RELATED; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   PIRSF; PIRSF001563; Folylpolyglu_synth; 2.
DR   SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR   SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
DR   PROSITE; PS01012; FOLYLPOLYGLU_SYNT_2; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          50..206
FT                   /note="Mur ligase central"
FT                   /evidence="ECO:0000259|Pfam:PF08245"
SQ   SEQUENCE   434 AA;  49267 MW;  37144FEA75F5D78C CRC64;
     MSSSSTKYIE LLKQLNYTNK FKQNKQNLDS MLHILKLVGN PQDSLKCVHI AGTNGKGSVS
     LKISKALQLN GLKTGLFTSP HLFYYGERIQ INGQYWEEDF VTENLSTLFS IANKNNIQLT
     FFDYLTGLMM IYFKEKKVDV AVLECGLGGK LDSTNVIQNP LASVITSIGL DHTEVLGNTY
     SEIALQKSGI IKPKCPVIIG PNAIPYSVFQ EQAAINQASL YKVKQTTFQL HDYNIENTDI
     ARETMKVIKM TYPDFNSLDD NLIEEGIKAE QICRMESLEA SLAKKYSPYK IIFDVGHNPP
     ALEKVLLRIK KFYPHKKVRI VYGTSSQKDA IDSLMVLAKQ CDYIHLIQAT HFRAMKINYL
     HNCSLQLKNN MQNYEDIFMP LSKEGEIKAT LDYALKNSDK SEILLICGSF FIQKEAREYF
     GIQDKKDPIQ LSSR
//
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