ID Q22WV2_TETTS Unreviewed; 434 AA.
AC Q22WV2;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 3.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=Folylpolyglutamate synthase/dihydrofolate synthase, putative {ECO:0000313|EMBL:EAR89761.3};
GN ORFNames=TTHERM_01332110 {ECO:0000313|EMBL:EAR89761.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR89761.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the folylpolyglutamate synthase family.
CC {ECO:0000256|ARBA:ARBA00008276}.
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DR EMBL; GG662811; EAR89761.3; -; Genomic_DNA.
DR RefSeq; XP_001010006.3; XM_001010006.3.
DR AlphaFoldDB; Q22WV2; -.
DR STRING; 312017.Q22WV2; -.
DR EnsemblProtists; EAR89761; EAR89761; TTHERM_01332110.
DR GeneID; 7844397; -.
DR KEGG; tet:TTHERM_01332110; -.
DR eggNOG; KOG2525; Eukaryota.
DR HOGENOM; CLU_015869_1_1_1; -.
DR InParanoid; Q22WV2; -.
DR OrthoDB; 7073at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IEA:InterPro.
DR Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR InterPro; IPR001645; Folylpolyglutamate_synth.
DR InterPro; IPR018109; Folylpolyglutamate_synth_CS.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR NCBIfam; TIGR01499; folC; 1.
DR PANTHER; PTHR11136:SF0; DIHYDROFOLATE SYNTHETASE-RELATED; 1.
DR PANTHER; PTHR11136; FOLYLPOLYGLUTAMATE SYNTHASE-RELATED; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR PIRSF; PIRSF001563; Folylpolyglu_synth; 2.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
DR PROSITE; PS01012; FOLYLPOLYGLU_SYNT_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 50..206
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
SQ SEQUENCE 434 AA; 49267 MW; 37144FEA75F5D78C CRC64;
MSSSSTKYIE LLKQLNYTNK FKQNKQNLDS MLHILKLVGN PQDSLKCVHI AGTNGKGSVS
LKISKALQLN GLKTGLFTSP HLFYYGERIQ INGQYWEEDF VTENLSTLFS IANKNNIQLT
FFDYLTGLMM IYFKEKKVDV AVLECGLGGK LDSTNVIQNP LASVITSIGL DHTEVLGNTY
SEIALQKSGI IKPKCPVIIG PNAIPYSVFQ EQAAINQASL YKVKQTTFQL HDYNIENTDI
ARETMKVIKM TYPDFNSLDD NLIEEGIKAE QICRMESLEA SLAKKYSPYK IIFDVGHNPP
ALEKVLLRIK KFYPHKKVRI VYGTSSQKDA IDSLMVLAKQ CDYIHLIQAT HFRAMKINYL
HNCSLQLKNN MQNYEDIFMP LSKEGEIKAT LDYALKNSDK SEILLICGSF FIQKEAREYF
GIQDKKDPIQ LSSR
//