ID Q22Y61_TETTS Unreviewed; 4416 AA.
AC Q22Y61;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 101.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EAR90163.2};
GN ORFNames=TTHERM_00355100 {ECO:0000313|EMBL:EAR90163.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90163.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662749; EAR90163.2; -; Genomic_DNA.
DR RefSeq; XP_001010408.2; XM_001010408.2.
DR STRING; 312017.Q22Y61; -.
DR EnsemblProtists; EAR90163; EAR90163; TTHERM_00355100.
DR GeneID; 7845911; -.
DR KEGG; tet:TTHERM_00355100; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_0_3_1; -.
DR InParanoid; Q22Y61; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 1167..1572
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1710..2036
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2224..2340
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2569..2655
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2712..2972
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2986..3316
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3343..3564
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3813..3926
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3959..4098
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4105..4412
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 578..605
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1079..1106
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1303..1330
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3199..3261
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3512..3539
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4416 AA; 510749 MW; BD6F8A06ED75A0C6 CRC64;
MNNSFRRRGS SVSRNTSQQS MTSSQQQRMN SQRDFNGEEQ DQYQDMDQQQ YYSENPQQQQ
YNQHDNNQYY SNGNSNKNDY SQQQQQFQSQ QAKMSQAKQM LVNRLFQKVQ VGNLNQIVRY
RGNSQDTSMT PKIVIDNWKQ QQLGNPKPKD ILPPIVKAGA QTTKGNNQED GNNLSMTINE
LVRPTSKQIS KSFRLQALGT KRANSIGQKN NLNNSSNNIP ASNLQPPLNN NAINLYDNSF
SLMLPPSRNI ISRDKNKKRM IQGLNQTMMD QTSFNQIEEV QDNYQQDGSF YGGAPFNVSY
KIKPVKILMD EMIGTNNTSL EYYQTQQMKK VFQSQASKSV LRDDDTIGPD QSQYNADSSG
NQIEKGLYKQ ASDTNIIENN GETFLSRDID SFIQAVRESK VPLSQFIYLV KIQQNSNDAY
NMKVVKYHEL KKNNINDYYT LSSQGVTRFE NNKPSDFVHL SDWLKERDQF NEIKSLKFFQ
KFRKWKTLKK WCKIIYQQRH KQLGDILNEK LFILKPIYQK LLLNHRALCY DIEKLRFVDV
QGSDTLTLQE FQDLQQNQRS DVASKLETFS QKLHDNCRKG IKEEIDQLRL KILKAKSNEE
EQMREQAHEV SIKNQVMDEK KQIWESLGFP QDMNYGQRSM MRNEFVRFLR LAYLLDFVAI
QSLGNVYINS ATDFLSKIKE TADCATQNMI LESDPDKLYQ EFDPMFKIDF KLKYDLKNIN
QNLVVQTQQY RAANLKKNLD DFDLEKFSEF TKEITNEEEQ QQQQQENKTT LQVDEELDDD
DIKVKREAVN IHTSWLQVLP SRKEFLDTIQ HIFSEGLDCI QNIERWSKHQ QFLIYVKGLE
EWDEIIGEKW TKPESYSLNP TTWIKESMQQ NSFMEDCFKV IESSFKRIEK FQEEFKPYFN
MFWREINCNI SILENPRLLR QQKTFSLALK CYQDNTEIFN IKFIQQANLG LFKAITTDLA
KQIIPDHTKR VHELETVLLK IYRERSQKVR QWLEQAQGAL SGGVTEIEQF VERKNALDRI
YKEQSGKKDE LMNLDLLLGL LKSKQVQELQ KADTDLLLKL NDLDSKLNTA LNNAETQTTQ
DIDKQKLKLQ DKIKMLKEKA VELLEESQNK KYLEMTVDQK LREAYVKELI DIDQRIKMQE
DNMNKYIQYE EILAVQETAN YETLLSAREQ LNLRLSMWKG ILEFDALQKD WENLPFASIN
AKQIASQTEQ YIRIVNRCKK NLPENKVIDH LMNMVWKYKD TMPVVTALRS EYLTEDHWRD
IKAILKSDFS IEDADFTLKK LLALQVDKHQ EDIMDISVRA AQEESLRQQI DQVEKRWEEV
ELHLKQYKDS NDLWVLADVD ELIQEFDEGL ATINNILASR YVRPLRARAE KMQQSLLLLS
DIVDKWVEYQ RKWMYLENIF SAPDIKKNLP QESHQFDVCD KFLRQLMKKT SMNRKIIKLI
KWPGTTLNEN LGKNCEALDV IERQLEDYLE LKRQSFPRFY FLSNDELLEI LAKASKLEEV
EPHLGKCFEG LVKLYMGPDK TTSNSNLIYG MISPEGEVVE FSKYVQAKSN VEVWLDYLQK
EMFECIKKKM REGLQEYMDG KKKRNEWILT NKGQVVATIS QILWCLNTQD YLIFDPNNTE
KGNMWEWYEV CVGQLQQLTA LVRGDLSSLH RKIIVALITT DVHNRDIVER LANLSIESVT
DFNWQQQLRY YWDERQDDCV INQVTAKITY GYEYLGATSR LVITPLTDRC WITITSALEN
KLGAAPAGPA GTGKTESTKD LAKSLGRLCI VFNCSDQITA AMMNKLYSGL VQQGAWACLD
EFNRIDIEVL SVIAQQLLTI RIALLAEKEK FEFEGIEIPL KNTYGVFITM NPGYAGRTEL
PDNLKSLFRP VSMMIPDYAM IAEIMLFAEG FENAQTLSKK MVQLYKLSSE QLSQQDHYDF
GMRAVKSLLV MAGSLKRAES KLSEDIVLIR AMRDSNVPKF LKDDLPLFSA LVQDLFPGAE
IPEVQYGNLE FVIHQCLKSS GLQVVDTFVT KIIQLFDTMN VRFGVMLVGP TGSGKTECYK
NLAKTMSTLR KQNDPDQRYQ YVDYHVLNPK CITMGELYGE VDVFTQEWMD GLASSIIRNV
NTPGLDGTWD PRHRDWIVFD GPVDALWIEN MNTVLDDNMT LCLANSERIK LRQELRMVFE
VQDLAVASPA TVSRCGMVYL CHEDLGWMPY VKTWTQNYIN TTSKEEAVNH GKIYMSRNCL
DGLINMFNNT FDQTSKFTRN FYEPFPTIQI QQANNMCNIL QVLLKTLITS DSDEEILKRI
NYMYVFSLIW GVCGSVSQKH YDTLDVYFKD TFQQLRFPKC ETIFDFTVET NQQKNFVPWE
VKPEDFAYSR DTPYFNLLVP TVDTKKITHI LEKLIYIQKP CLFTGDTGVG KSVIVQNFLY
NAKNKDVKSE KATINGIFLN FSAQTNPKQT QLAIESKLNK KGKTLFGARP NERIAIFIDD
VNMPALESYG AQPCIELLRQ LADKGGFYDR QKLFWKNIED TTLICAGAPP GGGRNPLTPR
FVRHFNVFCL PQPSNSTMEQ IFGSIMKGFT SSYNFSEGVK KSHEAVVKST IDIYNIICKD
LLPIPSKFHY IFNLRDVSKV FQGILQVRPQ SVNSLESLTK LWIHETSRVF ADRLVNDEDR
GWFKNQITSM VSRYFNLSWS QEEIFTVPFL FSDILKLDLG QNIYEEITDR PKVIKNLEEK
LEDYNLSSND KMNLVFFDDA MEHIVRISRI LRQPRGNAML IGVGGSGKQS LSKLSSFVMK
CEVFQIELVK NYNSQSFRED LMKIMNRSGV EGIPTSFIFT DVQISSESFL EDINNLLNTG
EVPNLYAKKE DLDNVINNIR TVAVKLKRPD SPESLWSFFV ERVRENLHII LCMSPVGEAL
RVRCRKFPSL VNCCTLDWFP PWPKEALLSV AQRFLGQVEL PSLNIRDSLT EMCMRVAVDV
SQQCDLFYKE LRRRIYTTPK SYLDQIKLYC KLLTKKREEM LSVKKKLSDG LEKLQTTNDI
VAQLKVEMEA LQPQLEEQQI KTDQFIQQLS IDSAEAGEKE LAVSIEAEKV NEQAQEIKVI
SDEAQTELNK ALPDLQKAEE ALKSINKADI DQVRTYKKPP EIVQMVLECV LCLLGEKNDW
ERALKVLQDN FIERLQKYDK DSIVEKNLNK ARVYFKKPEW DPVNIQKASS ACSSIAKWCN
AMDNYSKVAK NVNPLKEKVR DLQSKLDVKN NELKLKMNEL QKVKDKVQKL QEECDKTVQI
KKQLEEELER TKNRLIAAEK LQDLLADEGV RWKNQIATID VTIQQLIGSV FLASASINYL
GGFISKYRDP MTKSWVEGMQ ELGVPMPENY SLADTLETPI TIRDWNLQGL PNDAFSIDNG
VITKQSERWP LMIDPQGEAN KWIKNHEKDN NLKIVRFSES HFLSVIQGAI SSGYPVLIEN
VSERLEPSID SVLHQQTFEV DGRKLIRVGD KKIDYDNRFK MYITTKMANP HYLPEIFIKV
TVINFSITFQ GLQDQLLGDV MKNEKPEIEK QRDETTVSIA NAKKTIKEAQ DKILELLANS
KGMILDDIEL IETLEKSKKQ SAVIAKDLVA AQQIEEQINI SRSQYVPVSI RGTVLYFVIS
DLSGIDPMYQ YSLAYFKKLF KIALETSQQT NVLEERLLNL SENITKTLFM DICRGLFNTH
KKLFSFLICT AIKRQREEIT QNSWNILLRG PALTIKDTSR IPDNPAKGTI SDKQWITLFE
CSLQITQFKE IPNLIKKDMA SWASFIQSED IYHEKLPKGC EEIDRFLKLI LIKIFRPEKV
MHSFSHYVSD EIGKFYDEIV TSNMESVYND SDCFTPIIFI LSSGADPTSL LLKLAKQKEI
QINQISLGQG QGKKAEILIE KAKNQGTWVL LQNCHLAKSW MGSLEKIVEA FPSSNFIQND
QFRLFLTSMP VNYFPVSVLQ NGLKLTTEAP RGLKANLKRS YQEFNQEFLD SCSYKPVQWN
RLLFGLSFFH AIVQERRKFG PLGFNKAYEF NDSDLDISTL TLKMFLNEPT DEIPWEAMLY
MTGHINYGGR VTDDWDRICL LSILKKYYNE EILKDQCKLS GSGIYYVPLS DQVEQIRNYI
ENLPNFDDPE VFGMHENANI TFNSQESVKM IETVISIQPR VSTSGGTGKT QDEIVMDLAK
DLESRLPPLL DKNTGNAELF KKTDAGSLPS LTTVLLQEIE KFNRLLGVCK DSLSNLQKAI
KGFVVMSQEL DDMYLSFLNN FLPPIWKKVS YSSLKPLSSW FIDLIERVNM MKKWLEVGNP
VSYWLSGFYF PQGFLTGVLQ THSRKYKIPI DSLSFKYKIM SIDYDKILAG PKDGVYIYGL
YLDGARWDTP MDSLVDQQIG QLYSTMPMIH FNPQENYTQP EDNYSCPVYK TSDRVGVLST
TGQSTNFIIA VSLNTKHEAP EFWTLRGTAL LCQLND
//