GenomeNet

Database: UniProt
Entry: Q22Y61_TETTS
LinkDB: Q22Y61_TETTS
Original site: Q22Y61_TETTS 
ID   Q22Y61_TETTS            Unreviewed;      4416 AA.
AC   Q22Y61;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   24-JAN-2024, entry version 101.
DE   SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EAR90163.2};
GN   ORFNames=TTHERM_00355100 {ECO:0000313|EMBL:EAR90163.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90163.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG662749; EAR90163.2; -; Genomic_DNA.
DR   RefSeq; XP_001010408.2; XM_001010408.2.
DR   STRING; 312017.Q22Y61; -.
DR   EnsemblProtists; EAR90163; EAR90163; TTHERM_00355100.
DR   GeneID; 7845911; -.
DR   KEGG; tet:TTHERM_00355100; -.
DR   eggNOG; KOG3595; Eukaryota.
DR   HOGENOM; CLU_000038_0_3_1; -.
DR   InParanoid; Q22Y61; -.
DR   OrthoDB; 166463at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF34; DYNEINS HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          1167..1572
FT                   /note="Dynein heavy chain linker"
FT                   /evidence="ECO:0000259|Pfam:PF08393"
FT   DOMAIN          1710..2036
FT                   /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT                   motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12774"
FT   DOMAIN          2224..2340
FT                   /note="Dynein heavy chain AAA 5 extension"
FT                   /evidence="ECO:0000259|Pfam:PF17852"
FT   DOMAIN          2569..2655
FT                   /note="Dynein heavy chain 3 AAA+ lid"
FT                   /evidence="ECO:0000259|Pfam:PF17857"
FT   DOMAIN          2712..2972
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          2986..3316
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          3343..3564
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   DOMAIN          3813..3926
FT                   /note="Dynein heavy chain region D6 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF03028"
FT   DOMAIN          3959..4098
FT                   /note="Dynein heavy chain AAA lid"
FT                   /evidence="ECO:0000259|Pfam:PF18198"
FT   DOMAIN          4105..4412
FT                   /note="Dynein heavy chain C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18199"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          756..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          578..605
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1079..1106
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1303..1330
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3199..3261
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3512..3539
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4416 AA;  510749 MW;  BD6F8A06ED75A0C6 CRC64;
     MNNSFRRRGS SVSRNTSQQS MTSSQQQRMN SQRDFNGEEQ DQYQDMDQQQ YYSENPQQQQ
     YNQHDNNQYY SNGNSNKNDY SQQQQQFQSQ QAKMSQAKQM LVNRLFQKVQ VGNLNQIVRY
     RGNSQDTSMT PKIVIDNWKQ QQLGNPKPKD ILPPIVKAGA QTTKGNNQED GNNLSMTINE
     LVRPTSKQIS KSFRLQALGT KRANSIGQKN NLNNSSNNIP ASNLQPPLNN NAINLYDNSF
     SLMLPPSRNI ISRDKNKKRM IQGLNQTMMD QTSFNQIEEV QDNYQQDGSF YGGAPFNVSY
     KIKPVKILMD EMIGTNNTSL EYYQTQQMKK VFQSQASKSV LRDDDTIGPD QSQYNADSSG
     NQIEKGLYKQ ASDTNIIENN GETFLSRDID SFIQAVRESK VPLSQFIYLV KIQQNSNDAY
     NMKVVKYHEL KKNNINDYYT LSSQGVTRFE NNKPSDFVHL SDWLKERDQF NEIKSLKFFQ
     KFRKWKTLKK WCKIIYQQRH KQLGDILNEK LFILKPIYQK LLLNHRALCY DIEKLRFVDV
     QGSDTLTLQE FQDLQQNQRS DVASKLETFS QKLHDNCRKG IKEEIDQLRL KILKAKSNEE
     EQMREQAHEV SIKNQVMDEK KQIWESLGFP QDMNYGQRSM MRNEFVRFLR LAYLLDFVAI
     QSLGNVYINS ATDFLSKIKE TADCATQNMI LESDPDKLYQ EFDPMFKIDF KLKYDLKNIN
     QNLVVQTQQY RAANLKKNLD DFDLEKFSEF TKEITNEEEQ QQQQQENKTT LQVDEELDDD
     DIKVKREAVN IHTSWLQVLP SRKEFLDTIQ HIFSEGLDCI QNIERWSKHQ QFLIYVKGLE
     EWDEIIGEKW TKPESYSLNP TTWIKESMQQ NSFMEDCFKV IESSFKRIEK FQEEFKPYFN
     MFWREINCNI SILENPRLLR QQKTFSLALK CYQDNTEIFN IKFIQQANLG LFKAITTDLA
     KQIIPDHTKR VHELETVLLK IYRERSQKVR QWLEQAQGAL SGGVTEIEQF VERKNALDRI
     YKEQSGKKDE LMNLDLLLGL LKSKQVQELQ KADTDLLLKL NDLDSKLNTA LNNAETQTTQ
     DIDKQKLKLQ DKIKMLKEKA VELLEESQNK KYLEMTVDQK LREAYVKELI DIDQRIKMQE
     DNMNKYIQYE EILAVQETAN YETLLSAREQ LNLRLSMWKG ILEFDALQKD WENLPFASIN
     AKQIASQTEQ YIRIVNRCKK NLPENKVIDH LMNMVWKYKD TMPVVTALRS EYLTEDHWRD
     IKAILKSDFS IEDADFTLKK LLALQVDKHQ EDIMDISVRA AQEESLRQQI DQVEKRWEEV
     ELHLKQYKDS NDLWVLADVD ELIQEFDEGL ATINNILASR YVRPLRARAE KMQQSLLLLS
     DIVDKWVEYQ RKWMYLENIF SAPDIKKNLP QESHQFDVCD KFLRQLMKKT SMNRKIIKLI
     KWPGTTLNEN LGKNCEALDV IERQLEDYLE LKRQSFPRFY FLSNDELLEI LAKASKLEEV
     EPHLGKCFEG LVKLYMGPDK TTSNSNLIYG MISPEGEVVE FSKYVQAKSN VEVWLDYLQK
     EMFECIKKKM REGLQEYMDG KKKRNEWILT NKGQVVATIS QILWCLNTQD YLIFDPNNTE
     KGNMWEWYEV CVGQLQQLTA LVRGDLSSLH RKIIVALITT DVHNRDIVER LANLSIESVT
     DFNWQQQLRY YWDERQDDCV INQVTAKITY GYEYLGATSR LVITPLTDRC WITITSALEN
     KLGAAPAGPA GTGKTESTKD LAKSLGRLCI VFNCSDQITA AMMNKLYSGL VQQGAWACLD
     EFNRIDIEVL SVIAQQLLTI RIALLAEKEK FEFEGIEIPL KNTYGVFITM NPGYAGRTEL
     PDNLKSLFRP VSMMIPDYAM IAEIMLFAEG FENAQTLSKK MVQLYKLSSE QLSQQDHYDF
     GMRAVKSLLV MAGSLKRAES KLSEDIVLIR AMRDSNVPKF LKDDLPLFSA LVQDLFPGAE
     IPEVQYGNLE FVIHQCLKSS GLQVVDTFVT KIIQLFDTMN VRFGVMLVGP TGSGKTECYK
     NLAKTMSTLR KQNDPDQRYQ YVDYHVLNPK CITMGELYGE VDVFTQEWMD GLASSIIRNV
     NTPGLDGTWD PRHRDWIVFD GPVDALWIEN MNTVLDDNMT LCLANSERIK LRQELRMVFE
     VQDLAVASPA TVSRCGMVYL CHEDLGWMPY VKTWTQNYIN TTSKEEAVNH GKIYMSRNCL
     DGLINMFNNT FDQTSKFTRN FYEPFPTIQI QQANNMCNIL QVLLKTLITS DSDEEILKRI
     NYMYVFSLIW GVCGSVSQKH YDTLDVYFKD TFQQLRFPKC ETIFDFTVET NQQKNFVPWE
     VKPEDFAYSR DTPYFNLLVP TVDTKKITHI LEKLIYIQKP CLFTGDTGVG KSVIVQNFLY
     NAKNKDVKSE KATINGIFLN FSAQTNPKQT QLAIESKLNK KGKTLFGARP NERIAIFIDD
     VNMPALESYG AQPCIELLRQ LADKGGFYDR QKLFWKNIED TTLICAGAPP GGGRNPLTPR
     FVRHFNVFCL PQPSNSTMEQ IFGSIMKGFT SSYNFSEGVK KSHEAVVKST IDIYNIICKD
     LLPIPSKFHY IFNLRDVSKV FQGILQVRPQ SVNSLESLTK LWIHETSRVF ADRLVNDEDR
     GWFKNQITSM VSRYFNLSWS QEEIFTVPFL FSDILKLDLG QNIYEEITDR PKVIKNLEEK
     LEDYNLSSND KMNLVFFDDA MEHIVRISRI LRQPRGNAML IGVGGSGKQS LSKLSSFVMK
     CEVFQIELVK NYNSQSFRED LMKIMNRSGV EGIPTSFIFT DVQISSESFL EDINNLLNTG
     EVPNLYAKKE DLDNVINNIR TVAVKLKRPD SPESLWSFFV ERVRENLHII LCMSPVGEAL
     RVRCRKFPSL VNCCTLDWFP PWPKEALLSV AQRFLGQVEL PSLNIRDSLT EMCMRVAVDV
     SQQCDLFYKE LRRRIYTTPK SYLDQIKLYC KLLTKKREEM LSVKKKLSDG LEKLQTTNDI
     VAQLKVEMEA LQPQLEEQQI KTDQFIQQLS IDSAEAGEKE LAVSIEAEKV NEQAQEIKVI
     SDEAQTELNK ALPDLQKAEE ALKSINKADI DQVRTYKKPP EIVQMVLECV LCLLGEKNDW
     ERALKVLQDN FIERLQKYDK DSIVEKNLNK ARVYFKKPEW DPVNIQKASS ACSSIAKWCN
     AMDNYSKVAK NVNPLKEKVR DLQSKLDVKN NELKLKMNEL QKVKDKVQKL QEECDKTVQI
     KKQLEEELER TKNRLIAAEK LQDLLADEGV RWKNQIATID VTIQQLIGSV FLASASINYL
     GGFISKYRDP MTKSWVEGMQ ELGVPMPENY SLADTLETPI TIRDWNLQGL PNDAFSIDNG
     VITKQSERWP LMIDPQGEAN KWIKNHEKDN NLKIVRFSES HFLSVIQGAI SSGYPVLIEN
     VSERLEPSID SVLHQQTFEV DGRKLIRVGD KKIDYDNRFK MYITTKMANP HYLPEIFIKV
     TVINFSITFQ GLQDQLLGDV MKNEKPEIEK QRDETTVSIA NAKKTIKEAQ DKILELLANS
     KGMILDDIEL IETLEKSKKQ SAVIAKDLVA AQQIEEQINI SRSQYVPVSI RGTVLYFVIS
     DLSGIDPMYQ YSLAYFKKLF KIALETSQQT NVLEERLLNL SENITKTLFM DICRGLFNTH
     KKLFSFLICT AIKRQREEIT QNSWNILLRG PALTIKDTSR IPDNPAKGTI SDKQWITLFE
     CSLQITQFKE IPNLIKKDMA SWASFIQSED IYHEKLPKGC EEIDRFLKLI LIKIFRPEKV
     MHSFSHYVSD EIGKFYDEIV TSNMESVYND SDCFTPIIFI LSSGADPTSL LLKLAKQKEI
     QINQISLGQG QGKKAEILIE KAKNQGTWVL LQNCHLAKSW MGSLEKIVEA FPSSNFIQND
     QFRLFLTSMP VNYFPVSVLQ NGLKLTTEAP RGLKANLKRS YQEFNQEFLD SCSYKPVQWN
     RLLFGLSFFH AIVQERRKFG PLGFNKAYEF NDSDLDISTL TLKMFLNEPT DEIPWEAMLY
     MTGHINYGGR VTDDWDRICL LSILKKYYNE EILKDQCKLS GSGIYYVPLS DQVEQIRNYI
     ENLPNFDDPE VFGMHENANI TFNSQESVKM IETVISIQPR VSTSGGTGKT QDEIVMDLAK
     DLESRLPPLL DKNTGNAELF KKTDAGSLPS LTTVLLQEIE KFNRLLGVCK DSLSNLQKAI
     KGFVVMSQEL DDMYLSFLNN FLPPIWKKVS YSSLKPLSSW FIDLIERVNM MKKWLEVGNP
     VSYWLSGFYF PQGFLTGVLQ THSRKYKIPI DSLSFKYKIM SIDYDKILAG PKDGVYIYGL
     YLDGARWDTP MDSLVDQQIG QLYSTMPMIH FNPQENYTQP EDNYSCPVYK TSDRVGVLST
     TGQSTNFIIA VSLNTKHEAP EFWTLRGTAL LCQLND
//
DBGET integrated database retrieval system