ID Q22YH7_TETTS Unreviewed; 624 AA.
AC Q22YH7;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Tyrosine kinase family protein {ECO:0000313|EMBL:EAR90308.2};
GN ORFNames=TTHERM_00607140 {ECO:0000313|EMBL:EAR90308.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90308.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662800; EAR90308.2; -; Genomic_DNA.
DR RefSeq; XP_001010553.2; XM_001010553.2.
DR AlphaFoldDB; Q22YH7; -.
DR STRING; 312017.Q22YH7; -.
DR EnsemblProtists; EAR90308; EAR90308; TTHERM_00607140.
DR GeneID; 7836530; -.
DR KEGG; tet:TTHERM_00607140; -.
DR eggNOG; KOG0194; Eukaryota.
DR HOGENOM; CLU_453088_0_0_1; -.
DR InParanoid; Q22YH7; -.
DR OrthoDB; 179994at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418:SF294; NON-SPECIFIC PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EAR90308.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transferase {ECO:0000313|EMBL:EAR90308.2}.
FT DOMAIN 342..615
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 224..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 73404 MW; 8A30BCED07C6C169 CRC64;
MEEDQKENTT QQEEFQAVKT ILILLFSEFQ PIHYGHLKMM ELARQYLEEK YKDQQINIKG
ILIPYSKNQL YFQYLEEDVR LRMISIAIQS SEWITLNDSL VEKKAKNQKE LISHITSKTK
ESEQVQVYQV MSLDKYQHIQ KNIEAFTDQN IIFVEYRFTY EEDQSEEIKA LIKSIPRFHF
IKDNSFDFDI HSQVIRDTYE GGFDISLYVC PNVVKFHKSQ NVKYKKNQSK ESGSTKQSNI
KKQPNKQKGM TKDQKNKQNE KKDTQEQTQK QQLKPQIKPI NLKKFIDFDF NSIDYKKLSG
FNDISIISKV EKIPEQTKDE NNNNDADDQD EIQEENKQQA SQKNKDFLGS GLQARVISMK
YQIEELKEIE VAVKMVKFEN QISRRQATFY RDLRGVWRCN GHPNIVQAYG AGNYKEIGYI
VLERCAKQRF KNWLSLQSAQ RLFVDFNFMQ LITNLSSGCE YMSKMGILHR DLQINNILIK
LKGDDQDKEN FEVEEIEHLK ISDFGVSAIE EDKQNIVKGS TRHYSPESIE DKANYTEKAD
VFSFGALLYE IFYKHWVFSD CTVSESCIKT KSGELSRFDD TIPSQIKEII QLTWKFDPKE
RITFSSLTQI LQQYTNSLNQ QKTN
//
