ID Q232U3_TETTS Unreviewed; 703 AA.
AC Q232U3;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 05-MAY-2009, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Adenosine/AMP deaminase {ECO:0000313|EMBL:EAR91542.3};
GN ORFNames=TTHERM_01321550 {ECO:0000313|EMBL:EAR91542.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR91542.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Purine metabolism; purine nucleoside salvage.
CC {ECO:0000256|ARBA:ARBA00005058}.
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DR EMBL; GG662771; EAR91542.3; -; Genomic_DNA.
DR RefSeq; XP_001011787.3; XM_001011787.4.
DR AlphaFoldDB; Q232U3; -.
DR STRING; 312017.Q232U3; -.
DR EnsemblProtists; EAR91542; EAR91542; TTHERM_01321550.
DR GeneID; 7842044; -.
DR KEGG; tet:TTHERM_01321550; -.
DR eggNOG; KOG1097; Eukaryota.
DR HOGENOM; CLU_024484_0_0_1; -.
DR InParanoid; Q232U3; -.
DR OrthoDB; 4403at2759; -.
DR UniPathway; UPA00606; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR11409:SF39; ADENOSINE DEAMINASE 2; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Purine salvage {ECO:0000256|ARBA:ARBA00022726};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..703
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004201529"
FT DOMAIN 509..629
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 703 AA; 80803 MW; BC762EF5F7CC1852 CRC64;
MNRILVATTL ILLLSCSLVV EAKKLRSHQA PLRNSKPYQD ILEKAKKLMG DQNAQKVNGK
LKELKNMSQQ QLVDYFANHK YSDVQDYWFQ YYLLSELLLF TDSNTWLSPS KSQINDPLYD
EFVQKDAEYS QYLQSCRDQS NKFITENSSE SLELGENGTL YDLEYTYETL ELIEQDVFYN
HVYSKLPKGV IHHLHWSAGT DYQGFITSIR AAINSQPYDS ERIVVVSVQV YLEDATVGKV
ATEKYFNKYF LTKQKYVDPN NLQSVIDANQ DVLNQFAQNV KENKKCLNYI KDNNGFNPGN
LDPYIRGFVY WKSCNGSIYD DGMSQEGQAK SLEDLSLMLK ESIACFQSDE QAIKRLPKSY
LKDNAFETKE TKEILGVWFF FEQIFQSVGE LQDNQDIFKQ LTVNMFMSFK DQNTYGVEFR
NKNDKFQIGT FQESSDQFEV PYSFITPGRK VAGKGSKGGA IVQAAPKITD PNFVGIDFFA
FEDDPYNGAR NFFPGAFTDV IKGETQSYFD QMFNYLNNQN GNIYLHAGET QFFPQGGIDN
KYTNKNYIND NLIHAALLPG VKRIGHGFEA YKNNLLLSII NQKNISFESC PISNQVLNFN
EVYTNPFLNL LRNGLHMAIS PDDPGLFGYI GVAMDWFYVL METDVKPSEV YLLLKNSIEY
SSIKEIRDNS QQYLQRLRDD LDAFFSDLPD VCPADNENDN QDQ
//
