ID Q233Y7_TETTS Unreviewed; 840 AA.
AC Q233Y7;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Calcium-activated chloride channel protein {ECO:0000313|EMBL:EAR92115.2};
GN ORFNames=TTHERM_00107180 {ECO:0000313|EMBL:EAR92115.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR92115.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG662767; EAR92115.2; -; Genomic_DNA.
DR RefSeq; XP_001012361.2; XM_001012361.2.
DR AlphaFoldDB; Q233Y7; -.
DR EnsemblProtists; EAR92115; EAR92115; TTHERM_00107180.
DR GeneID; 7846612; -.
DR KEGG; tet:TTHERM_00107180; -.
DR eggNOG; KOG2513; Eukaryota.
DR HOGENOM; CLU_336676_0_0_1; -.
DR InParanoid; Q233Y7; -.
DR OrthoDB; 180810at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF73; INCREASED SODIUM TOLERANCE PROTEIN 2; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 346..827
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 135..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 99437 MW; 71E1579A9A29BC34 CRC64;
MFRQKSPRKS TTYNQERFDD GPQFALVLNS DLSQIQISTI SKQFSMYGLK VLQTQSLDRK
KNILFIELSN ILTVFTEAQE LQIRKNYKLS KTQIQANELM LIKAQNQYNI EVNSPESQKS
DYYRIDQILN NIQNPMDDSE ELNSNQNGGS AGQSQATFQE KKDKVASKQQ QYFRFDSASP
TQRSLLQKLE KANKETNGYK QNQLQQNQQE TFELLTKQSN QEKPSQNGHS NQINGTTKTY
NKKISKEEQV KLLEKIDPRI QQYEKLNVIK TEMLYDLDKE GNVIMSKRGL GIFTPAERLR
ITYSYMNKIR IKDLRFLEFL QEQQLITEII PLHEKNAAIS DSIQSIEDYY GENISSYFEF
LDFYQKWLLY PAILGLITYV LSNKFFTKQY LYFYFFYTVF ICIWSSLFYI FWKRYESELQ
VKWGVFGKKI YKEDRNVNFK GQKRIKVTTM CEEEYYPRSK RLYLYIISTL ESLPLLVMAF
LLKVIIFNLN GLIHKNSMLY IESIASLTEV GGILAKLPLK ETIFNVIMIV FILKINEFYN
TISSKSTQRE NHRTNNDFNS SLVIKRFIFD LINRFTHFFF IAFVVRDINS LKSLLGSLFL
LDEVRKVATE SVVPWVMKKI ISMKKQKETN PEEDDNTIKK NEELNQLYAD SIREIEMLFY
DDFDDYIEVV AQIAFITLFA AVNPLASFFS YLFNILERSS DKFKLSNRLY RRPMPFKVQG
INAWNKVIFL ISIFCIFTNV AFLCFDYYKI YDLQIQEEYS QMCYDSDLNS SNNVNNLNVQ
ESQESINIWN QVYITMFSLE HLILLVITFL YYFISQQPKW VRVYKRRMAI QQVEQIQQQQ
//
