ID Q23419_CAEEL Unreviewed; 908 AA.
AC Q23419;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 2.
DT 27-MAR-2024, entry version 170.
DE SubName: Full=PH domain-containing protein {ECO:0000313|EMBL:CCD72509.1};
GN Name=tbc-2 {ECO:0000313|EMBL:CCD72509.1,
GN ECO:0000313|WormBase:ZK1248.10};
GN ORFNames=CELE_ZK1248.10 {ECO:0000313|EMBL:CCD72509.1}, ZK1248.10
GN {ECO:0000313|WormBase:ZK1248.10};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD72509.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD72509.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD72509.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284602; CCD72509.1; -; Genomic_DNA.
DR PIR; T34491; T34491.
DR RefSeq; NP_495156.1; NM_062755.6.
DR AlphaFoldDB; Q23419; -.
DR SMR; Q23419; -.
DR DIP; DIP-26274N; -.
DR IntAct; Q23419; 2.
DR STRING; 6239.ZK1248.10.2; -.
DR EPD; Q23419; -.
DR PaxDb; 6239-ZK1248-10; -.
DR PeptideAtlas; Q23419; -.
DR EnsemblMetazoa; ZK1248.10.1; ZK1248.10.1; WBGene00022880.
DR GeneID; 173986; -.
DR KEGG; cel:CELE_ZK1248.10; -.
DR UCSC; ZK1248.10; c. elegans.
DR AGR; WB:WBGene00022880; -.
DR WormBase; ZK1248.10; CE29155; WBGene00022880; tbc-2.
DR eggNOG; KOG2058; Eukaryota.
DR GeneTree; ENSGT00940000169065; -.
DR HOGENOM; CLU_011278_0_0_1; -.
DR InParanoid; Q23419; -.
DR OMA; FRYHNSH; -.
DR OrthoDB; 616243at2759; -.
DR PhylomeDB; Q23419; -.
DR Reactome; R-CEL-8854214; TBC/RABGAPs.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00022880; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0098981; C:cholinergic synapse; IDA:SynGO.
DR GO; GO:0005770; C:late endosome; IDA:WormBase.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005096; F:GTPase activator activity; IDA:WormBase.
DR GO; GO:2000643; P:positive regulation of early endosome to late endosome transport; IMP:UniProtKB.
DR GO; GO:0099161; P:regulation of presynaptic dense core granule exocytosis; IDA:SynGO.
DR CDD; cd01265; PH_TBC1D2A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF16; TBC1 DOMAIN FAMILY MEMBER 2B; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:Q23419,
KW ECO:0007829|PeptideAtlas:Q23419};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 17..114
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 630..829
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 126..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 286..320
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 355..389
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 126..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 103343 MW; E6656BD66B8D80A7 CRC64;
MSAAPGTISP PARELKTSAI CGYLHRIEVR SIGLITRRRY WFALCDSTPY LYWYKDSDDI
KCIGRVSLSG AAFTYDPREK GRFEIHSNNE VIALECSSDK QRNEWMKALQ STRKRSWKAT
KSKSDSSLDI SSLTGRNSSS VLEECSSPSP VPPPRSPKPK KRTQFLTEEE TDAETSSDVP
HSSEETAEVV EDTDNTKIPA EGSATEWYLN PNGQLNERSL QMPKTIESPE TVLKRLADQS
IEAPFRAIRR NLSTWSRSRQ NTSDEPVVGS RKGTVSSVDL TPEEKVIELS DKVSSLEEVV
DSLRAALLLA QRNNEALQKI EDMGDNKEEM REYILEKERQ VTELHISNSM NARRVRDLED
QNVRLEDTIN DLQQSVEAFR ESLRTKEELI LRMCEEENRE DLLGSISERS SNIPADANGL
VSDVEVPEGI LVDVSSVDCE EATRKVLDEE NVRDIGELQD LVEGYRTQNQ FLNAEIVQLH
AITQSLEDRE KKLIRQNFDL EACYYQLKSR YLMVLNHFKS PTKPGKIMEP GVLKELLEES
ARTPRESQQN LTDQLGFYKK DDFSESDDLL DTATFYMKKA GDVVEATKLE QSEEYMKWLQ
SWDAFLVNNT VSRQTAIMSS PDLKTLIRTG VPPAYRGRVW KIIVTHWVKD KQAELGNGYY
QSMLRKAGTK KQDGSYDAAI KQIDLDLART LPTNKLFDEP DSANIEKLRN VLYAFRYHNS
HVGYCQGLNR LAAIALLNLD EQDSFWFLVA CVEHLQPEGY YTSSLIGAVA DQKVLRDLVA
EKLPKLAAHL RALEVDLSLF ALSWFLTCFV DVLPHSIYLT IFDAFLYEGN KVLFRFALAL
FKICEPHVLQ CKTIGTVHQC LSKAQEHIID FKSLAQVAFN ELNPFPQKTI ETKRQLYLTQ
LKDTGHCM
//
