ID Q235U6_TETTS Unreviewed; 1217 AA.
AC Q235U6;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR92302.2};
GN ORFNames=TTHERM_01433590 {ECO:0000313|EMBL:EAR92302.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR92302.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG662753; EAR92302.2; -; Genomic_DNA.
DR RefSeq; XP_001012547.2; XM_001012547.2.
DR AlphaFoldDB; Q235U6; -.
DR EnsemblProtists; EAR92302; EAR92302; TTHERM_01433590.
DR GeneID; 7845210; -.
DR KEGG; tet:TTHERM_01433590; -.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_275513_0_0_1; -.
DR InParanoid; Q235U6; -.
DR OrthoDB; 52684at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 650..756
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 91..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1217 AA; 141942 MW; C8F21BF0265B9490 CRC64;
MNQNQQNSKN PSDLRQGEYI RGQMFEVKQR SFKKMESGEE LIINFESSHT SIQKNLENIN
NNHHNEKGEI VFDMNTFRKN FEEELNTKDY SPISKIKGSP SKTFIQQDVD SNEQKELNLK
KSSEIQSSQQ SPSSSKQSDQ INENSSMKQS KNKESERKNT FEAFNKNETL MIRMLSDDQY
QNKKIEKIIE PIKSIKSNRR ILNESNTPVA RGFTQKKKPL DEIWKKKGLN ILFHVKKYIM
LLKNISSHNN FRSLSKNQFE IINDKANYYS FYKYNNYLVN AQTSFIEKIA FMGRQRIKFL
NSKLIQIIYN YFINNLIIIN PESVYKLLWD GFVLFLLVIN IFYVPLKIAF QDSGGLQWPY
LLTVFLNDIP GWVFLGDIIL NFFTAFYKKG VIIMEFKTIA KWYFKNQFFF DLFVFLPFIL
SKYFAIKYLD AILILRFNKI LKIVNNYFDL LNLKSDQAAI FDLIKLIFLI LFIAHFCGCA
FYLVSYIEIQ YGDYSNWLTH SFKITDPNSS DWFPCYIASF YWAVITMITV GYGDITPTTT
VERIFVILIC LVGCGVFAYS VNSIGSIISA ITQKSTNFRQ KMSLLTIHMK KRGLNTELQM
KVKKYFEYLN DEKLEDNQEG ENMLKELASS LKHEIAVDIY GKILNQKKIF FLNFTQPFLM
DLAPKLKEKR LGPEEIIYNE GESQPRIYFV MKGSVNLFIN VKKSNQQPYT ILKTVSKNGV
FGELGFFSGM VSNHGAITTN VVSLVYINIE DFLEVVKHHP LDHEKYKFLS DNYVIYSSSR
GLGSQCQGCG KFTHQIDHCP LLNYVPNKDQ IIQKHKRTED QIRIKEYKRK RDKSQSPWII
ADSLKQAVLQ LIVEVEEIKD IEDLYHRLEE MENNEDDYDD GNSSEHTEKK SQKNLDVAFN
IKDTKSITQK QEEKGEIELI NKIIRRGRRQ QTYRKVQVQT IQHKASFTIQ ADNIKSQPVQ
RKQSEVLDDS LNLHQEDQQI SNSTTSYKDI RAQIKRATFI KKMSTRKTGG GNNSTALDED
NLGLLPEADY RKISIRKGAG KTFQNSVMNN LIPKQLTNAE LEEQRIEQEK NLRVFSKILD
LDIPKEYKQY YPFNNKSNVI LLYNQRLRVV QKQNSSQQQT KIDNPRNIKE IYKNIKNKRN
SIQILNKQNF SFGSQLMTPK SSSNRILRKQ PAFSNFSSNI NNQNNNNNNN NNNNVNVHPS
KFKYAYEASS SNDSPIN
//
