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Database: UniProt
Entry: Q238R0_TETTS
LinkDB: Q238R0_TETTS
Original site: Q238R0_TETTS 
ID   Q238R0_TETTS            Unreviewed;      3525 AA.
AC   Q238R0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   16-JAN-2019, entry version 72.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR93160.2};
GN   ORFNames=TTHERM_00454060 {ECO:0000313|EMBL:EAR93160.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR93160.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662738; EAR93160.2; -; Genomic_DNA.
DR   RefSeq; XP_001013405.2; XM_001013405.2.
DR   STRING; 5911.EAR93160; -.
DR   EnsemblProtists; EAR93160; EAR93160; TTHERM_00454060.
DR   GeneID; 7824005; -.
DR   KEGG; tet:TTHERM_00454060; -.
DR   InParanoid; Q238R0; -.
DR   KO; K04958; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   SUPFAM; SSF82109; SSF82109; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2821   2840       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3113   3132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3152   3172       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3246   3267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3287   3307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3363   3386       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      224    417       Ins145_P3_rec. {ECO:0000259|Pfam:
FT                                PF08709}.
FT   DOMAIN     2598   2677       RIH_assoc. {ECO:0000259|Pfam:PF08454}.
FT   DOMAIN     3260   3396       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      261    288       {ECO:0000256|SAM:Coils}.
FT   COILED     1532   1552       {ECO:0000256|SAM:Coils}.
FT   COILED     2067   2087       {ECO:0000256|SAM:Coils}.
FT   COILED     2401   2421       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3525 AA;  414857 MW;  C6DA87F1B152160A CRC64;
     MSKQVSNQNI VFIQSRSPTQ SKLINNFVQE RDTPMSGLNI DEHQQNDKNL FHTIRQFPQA
     QALISDHSNQ HQTNEDGILE SHSLAPKDIL EQQKKAKLEL FKQRSLMKQP TIFRNQENEE
     KEDQQGEEKE GISQDINLKY GDIVYFKYYR EQSKGIVSGD GIAGNKIECV SVGNIIKSGS
     EEHFNQQQSV NGEGDDFDDI DEKQGYANQS NDPNYKRQIL NKKASLQFRK CLFRVTNSKK
     YYYQNLYNIE LKNMKSSSYK SKNQQQKLTD IEQKMREEQE ENQRAYQHKM GTNVIYGQEI
     QLEHIYSKCI VTLNPDVLAY EHCCRELSLE EIPSQWSNFI ITSSNNAKKT GEPVMYKEQI
     SIYSSENPYY WINIQQSQSS SSDDNTEAVT DLFDEGLEVN CTDRSASMKL SLYLGVNEQK
     ERSEQMEQQE NQPIQIGDVV YIYNRIVKGR IGVARKNQSQ ENDSQFQMKR VELKLETNDD
     FKQRKGLEIQ VLKVEDYTKN ISSQYEFFID TSEDEKRIET LWEIQRERNF DSSLASHDDN
     YRIKNIWTGL YLYLNDNDEI DLTLEGNLDK TFFSIKPKRV LQLIENTLVY QQPVKILQSL
     VDHTMYLRVK EDPNEEDEFN YFNQRGKQSA KKLGLMRNQC RLLEEKPKIV NTISSYNIKK
     DKRGEIEFEF IRADPKLINL ADRVSSLFPY LMNFYIFLLH WGNRIQKNPG SNEEWYYEYF
     KAFEQQKYLY NYVQQLYQSI ENLEDFLKPD TNLYERQRIL LDAGIVEILL LTLKLIHYKI
     YCHCEIDNQN QFQEQKNIND KLNSIPDRTA QKIASIKLLK TISVLYDILI KCIQGNSQCS
     SFVLKMQKDN FLFNQIKFHK SEVVMLLKEA TRYVDGDQKE QNVENMKKWV SKIQQISAAN
     VQEQTFIIEL LCLSITDHLE QPITEYQNSL RKLLFNQPRR FKDDDDDDAN GNERVKFSGK
     QRERKYTGFL KKSHLLSFKI EQDSPYIIFN LLNSNKSKFE NDNQDLYYTG KKGVVRDDEN
     INHFPFDHIN GSQVKGKTNT QLQQSIEKYE VYVLEVLNLY SLLSAGRNMK SIKCLQTLGL
     TKNFIYKCLQ SKKIDGSHLR QYKSILNLYD SFILNVSPFT PITGYHNLVF QNIDFKDFDP
     KKQPSFHLFR EIVVNQETKN SIRDEYQKLV DKNSLQAQEN DSNLLQLYAK CIVDREEQWY
     RESKTNPEKR HQISSLRIQE ELTIYTKEER NKIIEKLNHE ISLQQNPNAD KAKLSKFMME
     TFLQMLKIVK TRINLGYNTP EQNQRIMDII PNIFMALIEY KEEMQNVAIQ NDLTEIAAAA
     HKKDKRKNAA EADRFNQNWI YAFMRYNLEY SFDDLITTKI FIEAITIVNI ITKLNMYLYI
     VEVIQSKKYF TDDSLEFFYQ FKFSLEDQQK INRSNGVNLN VLIMQTLEYL KRDPILEQTM
     FKTLIKNFDY LKDLQNQMLE VEIIEDLQEI EIYKDVNGIT ENNQNSQRSP QDIKLMVFKT
     IQYFQFLEVL LKDKFFEIKV KDLKDEEEEK IYESKLTKIN ELEQSFDQLN LAIDYCISLF
     SKKIAVEGTK NKQQHYKLQL QNIFRHSRIP EYLLNLLDKV PQYNSVFIEF YRKLIKFFEH
     YTEDNMTNKR KLLDYITNIM NLCLVPNTLI ATPEKLSDKI QTPIQPIKIS KLCIQLLEEI
     KDDGTIIKDI INQIINLIEE NNPFNVSKDK FSNQNWKQMK YKIYRFGVDE LKCLALIQYF
     KILKSLTFAH NKKPIQSNQL QILNNFMHKR VLTDIVQPII ESYLTRFQIK FESQPEYLKL
     KLHTQGIILL AYCCKDFKIG IQEIQRFVMF DTLKAIIVSQ YSPFMLKRAY LKCLFEAYVN
     KVYDIEKDSS NETISNIELN DILTSEIIPI LSVTTSYKYL QGLIIHNEEK GQEVKGLRDN
     VTRNKYKIFK SNKDYEKAIW ADDQKKNDDQ ENIQEQGIVK DVSEYWKYLF KEGVIHFVID
     SFDEFSDILV GDQKDADYQG SVLSNFQFIG NYLQKLYEQI EIVEKEFKVI SIQQKTYVDF
     ELMRNVLDII PIGNPKKSGT HFIIDKNKEE KNQVVKLNIN NQEQAVENNN AGKQEINVAD
     YVKDLEQIEV QKQFKLQLVR KRIKLQEFLY QFYTYFHDTK SITKALYLAL NVQKLIFIPS
     QINHILKKYC NYEERYQNQL SLNSLSKKKI HSQAQDLEDQ AKQVMGTLYQ LATKSFKNEA
     VQDPVDLSIV NNIILSHKKA RSQQAQIDFI KIQFSKIIKL NIKDQLNILK KSVIDQEVEK
     DLLQAKSNPY RLEALKGKYS QDIDNCIADY EVYVKSNDED LKEDKSPLFN KSKTLLNNKI
     NGISNPNPIL DKSSNVARYD DLEEEEELTK VELFCLDRMM VDSQITLFLR DIQQELNIYG
     IDNPNEQEDE FLEELQDLEE EEKFTYQANS DINPQRRIFQ SYIQLFSQVF EEKKYYLVKI
     VRLLLEVVQI DDLTMSQLTS THHRERKRAK NKFDLLQLCQ SEVAGQEIFI HALNLIKVTS
     TYDELQEGLT FMICMLNRGN QFAQNCVLNY LKKNTDSLVD FFSFLRNFFN QEITQQIKGM
     FDQQAISNIP TEFEILALKI LRLIQLFCEN VNEDFQYFLM KQIEDETTQI SNYNVILEVS
     TFLSIFLEDD LLQMGRKQNI IIQCIDTLNE CISGQQEVVD CVAQNKRLFI YLNEKIIRNN
     FNFAQKKIVN PTKDELRRFE NYTANLKKNL ELFQSAIKFI LTIVSGVSKS EHLEFLLDQV
     QTNKLIRMID QIYEQRIKPK EDYVQMGQVC QHLSQDNDDD DDDNGKIFCS EDFCIEGKVT
     LIDQLIMSIG FNVFIFFYYI RDAFPDYQDK LLAFHLDEKK DLEINLDLSD FGLSAKPQEE
     KIDEKKQNQQ VLKNIRKQKS SRNNSIRAIS NSKGQSGITN EEQDDDSEKD QNEQDEEEGP
     KKSQENINEE IDKFSARKLL SKGLAHQILK DIATLENNEP NDQQKDTNEN IFTGKSKYQH
     IFDEHVDDSY LVKDKNRDYF KFFKNFVGSV EISNQHDILK KVYFQKPFYT KYLTPDIKKH
     LVYESDRDSD TERLMFLIDH ATYYEEQMIH KQKISQWGIF SYVADKWRLY KQISYYLVVA
     LTIITLATFG YTEETDNDVA NSSNNENIKN TFVVVSYIQL ILSFAILVSC AIERFPISVY
     RNVESQVYET IQRHKKNAGF PDDSISSVYN LIANKLYNVL SIKNAKSSLY VKILLVCFDK
     ENIYNLCYLI ITGFAFSNNL IYAFLLLDIV KRSEDLQNVI SSITKNALSL LKFSFLGLVI
     MYIYGIIGNQ SFKGDYQPEN GTIGDTFILT ITSTIKQGLK NGGGIAESLR SVDYDEHTFW
     SRYFFDLTFF IVINMLFIQM IFGIILDTFG ELRDNRQELL ALVTDTCYIC GLSRRFVEAN
     SDEDWYHHIY MEHNCYNLLF YIIYIRRKSE NDCDALEKYI KKCLDRSEGE NKLQLKPVDF
     TPIGKSLSIQ NFRSKEKDHN ESEEHDNEAH NESSENGKKQ SEKKD
//
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