ID Q23A85_TETTS Unreviewed; 1014 AA.
AC Q23A85;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=TTHERM_00829370 {ECO:0000313|EMBL:EAR93395.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR93395.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR EMBL; GG662725; EAR93395.2; -; Genomic_DNA.
DR RefSeq; XP_001013640.2; XM_001013640.2.
DR AlphaFoldDB; Q23A85; -.
DR STRING; 312017.Q23A85; -.
DR EnsemblProtists; EAR93395; EAR93395; TTHERM_00829370.
DR GeneID; 7830274; -.
DR KEGG; tet:TTHERM_00829370; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_307695_0_0_1; -.
DR InParanoid; Q23A85; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 62..339
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
SQ SEQUENCE 1014 AA; 118230 MW; 3087EE6C579C1B15 CRC64;
MNIEDFLNSF GNKGKNQEED IEKTIVEFID NEANDRSVDT KCITKLLIAF QMNQINLFQF
FEKMQFYFVN GREKTRQRAT EFIYLFFSRY SGLQMSQEEV ESLYLFFLTK LFDVATVKTA
NKVLLELLKN VIKHQEQMKQ KIDSKKAGAF KEFKFNLAKQ FIEKISDSKF NISQYSQDVR
DSVYINLRFL QENFTESCVE LGATYVKVII ESTEDEKDPR CIIKSFKLIR FVLENFSLSM
LKPFLEDIFD NLECYYPIDF QPDPEQDKKY QISPKDLSEA LDLCLINKHI LQKTLDIINE
KINSSYIDAK LAAMQTYQLV FKNYLPGQLL SSQRKQILNN LIENAQDIEE VELQDKVVDS
IKQYIVFITS TCKSDTNIIE NCYYDDLKLV NKHIFKLLED GLLHHNAALS EKLMKALIPI
NQNMNYTIVN SIVKYFNSRY TNKESIVAQR QLEFVLVILL AAEQEIKHSC DFMLNPFFYL
DEEKEKNLKN ILMGEIQNTN DESIQILSLA ILMKLAVYGK ASKEMDIEFM KVCEDIGITE
AELENYSETV KKCMVEYCYT VNSKLQESQI SFLELKLVGL LGQQNMNETV VNGFNSMILN
NTDGWKECFD FIIQHINNRD QQKLINLLLE KVISLNKEYV NKHIYQELTQ INNLIIEDKQ
TRSQLKTILS NVIKSDCELT EQEISSFKSL IQKPYESITL FTKLIKKLSK TIEIKDFFIQ
FSQNIQKSDI IKDKNITSFV LSLSKLFGNK IQKYLSNEEY KQFMGVMKSK MIDKNSSEFE
LKLYSRIFRG LLISMNNEAF QLLSQIIQSE IKGESNLSVE FYNTIMNSKN AQVQKSYLFY
SPTYAQRLFN TCVEVFYNKL NSIKNNPAEI QMKNKCYLVL TSTLLVSPFS ILKINKSISL
PILIEALTFS SDSQGLESAI KLLTRLINTD LNVIGSSSES LINCLLKLLQ QENNSVSCTI
EIIKCLAECI RFEYHLVKRY KKDVIDILDR YLSHKKRPVR RHAVYTVNQW HMII
//
