ID Q23AP2_TETTS Unreviewed; 1100 AA.
AC Q23AP2;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR93650.2};
GN ORFNames=TTHERM_00772070 {ECO:0000313|EMBL:EAR93650.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR93650.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662723; EAR93650.2; -; Genomic_DNA.
DR RefSeq; XP_001013895.2; XM_001013895.2.
DR AlphaFoldDB; Q23AP2; -.
DR EnsemblProtists; EAR93650; EAR93650; TTHERM_00772070.
DR GeneID; 7825552; -.
DR KEGG; tet:TTHERM_00772070; -.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_328879_0_0_1; -.
DR InParanoid; Q23AP2; -.
DR OrthoDB; 52684at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 642..752
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 1100 AA; 129542 MW; FB2CEC2DF9C1EA75 CRC64;
MKLKSLDENR AYQKRKTIKK EKSLFDFTPR LAIPEFTIPS IRQNDDDIQI SLDCSERHTL
DMNGDQTVSD HKLKKSASFM SKNTTKNNIS FNNRSDNNIL IHQDQEGFMK QQNDQNMDLY
SKVDFISEKN IALSIAGGSQ RNIPISATKI QKQLANRRQS KFYFSESESR FKIPSQNSRE
YKVENIENLP RLKSNFSLIS NIKGNLNKMQ QKVIAIGMLL VFYVKLKTLS GVNQITKQYM
LSSKVDNKSH QLKCLTYLND FSQISDKKQQ QLKKENNLIS LSTINNQKNE SGQQNKKCSF
IQFCFGCIPV IHPDSKKLFL FDIINLIFII LNLTYVPIET VIDTPFLQMY GNKWFIFITS
SISVYFFSVI LSLNMGYYDK GYCIMDRNKI LVRYMKLGFW VDILSTFPMF VSGINSKPVY
KMCNLFVILK INWIDKFFYK YFEICNLKKK IKKMVFLKFL YILLKILFFV HVFACVFLAF
SYHVNATDNW ITKYGSDLDS KGWFTKYVYA FYWGITIMTT VGLGDILPSN IYEVCVLSLF
MFFSCAAFAY SFNSIGIILD EMNQRSDLFV KEMRIVSRYL QMKKVDHELQ IEVRKYIEYR
FQFENEISQE EEKIVFKRLP ISIQEKLIIQ SNMAILRKIS FLQNNFSEGL LNKLCLTIES
EQWLNQDTIY KQDDVYAESS NSIKFYILES GQVQLLANAG NPDQPLVIKN ITDVEDFGSL
EFFNDEPRHY TAVTIGTTKL LSISRSKFLQ ILKQFPEDYE KFKMLCENAK MNKIQFDIKI
SCYCCQKYNH SLKECPKIHY IANKELSILK NMFSLPQQRK ASRRNFKLKI NSLYENHIIQ
ERAICYQQYN HDELNKIESP LITQEDILNT ETYRNGNGNI HKNQNNQKVL LNIATNDLIS
RVDFDIQEKN LNKLVRNQSF STRKSTCLRP TLFKQNTDAI NIDQNEDILK QQVESNYSPV
SLSQRKHHTT INLNTHDQQL FHKNQKKNTE SPSPHISYQK RHISINNLPQ DEINEKDISF
MIDNFDRLKN YKYYFPYNNY DNILNQYEKI RPKFKYQRLR KPSQYFLFPN LNFKKLTKNT
KNKIQSENKI DVTFNDSFNA
//
