ID Q23G35_TETTS Unreviewed; 579 AA.
AC Q23G35;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Tubulin-tyrosine ligase family protein {ECO:0000313|EMBL:EAR95425.1};
GN ORFNames=TTHERM_00077290 {ECO:0000313|EMBL:EAR95425.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR95425.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662704; EAR95425.1; -; Genomic_DNA.
DR RefSeq; XP_001015670.1; XM_001015670.1.
DR AlphaFoldDB; Q23G35; -.
DR EnsemblProtists; EAR95425; EAR95425; TTHERM_00077290.
DR GeneID; 7834410; -.
DR KEGG; tet:TTHERM_00077290; -.
DR eggNOG; KOG2158; Eukaryota.
DR HOGENOM; CLU_010131_6_2_1; -.
DR InParanoid; Q23G35; -.
DR OMA; NIEHEVY; -.
DR OrthoDB; 100598at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF154; TUBULIN POLYGLUTAMYLASE TTLL11; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EAR95425.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 67348 MW; 73E953497A661C6D CRC64;
MDLSVQPWAT NKKDQFPEFN GFGSDDSVDY SEQNKQPLKN YNLLNKDIDE DSKDDYDDED
LKSLGQNTEQ SVSQASSSSS QNQRKKKKIV IKVNTSKSRS ELKLLRILID KNGWKETFGY
EGKILWSGLS MNGEQLAYDE ICVNRYPQME ELAHKKTTGY FLNLFREYFP EHFDFFPKTF
LIPEQMDELK QEYKKNSKKL CIAKPSSGCQ GDGIKLIEGI KDLPISSYTP HANQLVVQEY
INNPMLIQGK KFDLRLYVLI SSLDPLIVYL HDEGLARFCT EPYEKPSKTN INNSYMHLTN
YSLNKNNPNF KLPTEEDLYQ DNDASKRTMQ VTWEQIVKAG YDKEEILGNI EDLICKFLAS
MHPYLLYNYQ CVFNKKQAKR FHVLGFDILL DDKGKPWFLE VNANPSFNIE HEVYQPDGKK
KVEQSPLDKY VKCRVVEDAI FIVNKKIEKQ LEIGRDNHFR GFKQIISGDF EEYKIMDMFS
DILKIYGKLS GFKFNSALTS SKFSKLAAYQ GMQNDKVIKN DYDLIFKKVL QNSQEQAMSF
YDFIRSIEIL AQRLNPQNFD PKNKLPSVSQ LVNNLIRQL
//
