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Database: UniProt
Entry: Q23K98_TETTS
LinkDB: Q23K98_TETTS
Original site: Q23K98_TETTS 
ID   Q23K98_TETTS            Unreviewed;      2827 AA.
AC   Q23K98;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   16-JAN-2019, entry version 80.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR96945.2};
GN   ORFNames=TTHERM_00194370 {ECO:0000313|EMBL:EAR96945.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96945.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662673; EAR96945.2; -; Genomic_DNA.
DR   RefSeq; XP_001017190.2; XM_001017190.2.
DR   STRING; 5911.EAR96945; -.
DR   TCDB; 1.A.3.2.3; the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family.
DR   EnsemblProtists; EAR96945; EAR96945; TTHERM_00194370.
DR   GeneID; 7823162; -.
DR   KEGG; tet:TTHERM_00194370; -.
DR   InParanoid; Q23K98; -.
DR   KO; K04960; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2384   2406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2427   2449       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2534   2562       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2583   2604       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2671   2694       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    232       Ins145_P3_rec. {ECO:0000259|Pfam:
FT                                PF08709}.
FT   DOMAIN      565    746       RYDR_ITPR. {ECO:0000259|Pfam:PF01365}.
FT   DOMAIN     1353   1532       RYDR_ITPR. {ECO:0000259|Pfam:PF01365}.
FT   DOMAIN     2055   2156       RIH_assoc. {ECO:0000259|Pfam:PF08454}.
FT   DOMAIN     2517   2700       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       93    120       {ECO:0000256|SAM:Coils}.
FT   COILED      128    148       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2827 AA;  330286 MW;  5AA403AB2F55436D CRC64;
     MSQVKFGDYI TIQGTLLDKN NTNGAHYGYM CTTGFTNNEI YLEKQSKSIF ANTSNQDQQI
     SQKPEDNVFS IKNYREYVFQ IWPKLDYDAH KKYSKLLEEK NQIQKKLKSS KDNIDISEED
     QERMKEYLNE VREKIKIAKI AKESEKANNL KQLESVKGNF VCYGQEIFLM HADSQSFLNG
     LLQASVSEKS AFMLQVTKFF QRGMVFKFQP KYKLRKEGEI IQYKDQISIF NVKQQCWANF
     VPSNITQQDK IIQGPTPTNY YQSIDFQKYQ NRQRVEVFLT KVKEAFWQIH IHSDYIQNQE
     TSIKGGDLIY LYHTELQGAL TADISYDNKK GYSEAYIRKY QGEYELEKYS VASIWEIEKD
     SCFDRGSNIP VSSLSNQDKK STQSFKIRHF LTGKVLSIQQ VNQGQYIPCL AKDDLTTLEN
     SSKIQFVSTQ NDENEIMEDN HCYLIKINDQ FIQANSSIQY TVQKHEKNSE NKLNVTDFKD
     VTENMIYKPI DDSEFEVYRN GLTCVDKGST EENAFQVIKL TEEEKQNILY VNSSLNILHK
     FLQKLRNVPY REPLPKKEYI KKVGQILSDL VLFVVKTESK NPLECEGIPI PKRQKIMKDY
     KFIELLVDLL YYPFKTEVYK MKELDQIDPD TVKIFKLCNV LINNSIKEYR PNEIYASQWI
     NLLIFQSEMT EGYCDIGSEE TLTELIDNNK KILETIDEVT VNKFLQMLME NQNKKYVKLI
     RALILCNGQP VHNQELISNY LLSGMDAISN DEDETGQVSQ NKVSQVLQRQ VDINKPLIIQ
     AVKYINGEVW VQSPFKENYG KFMLLSKFQE MSTESQENLD KFEYFSEMIG MLSDLCKSRN
     YTAINQLVHV YKRRVCFEIV QNSLFDPYLR RSFVMLIHTM YLDISDFKKF SLPNNIRVWT
     EIEKAKSIVS VYDQQQNLEK VMGLNSFVSP LLYASNHLKV FSIEYIIGIA KSKYMSSLKE
     PENLLTYSIL QMIQDLVDFG FFDNSDELES LVKNIIKILD SSLDVGNQNE EEAAEEVVKL
     LSCRTTISKG NIPQALKKLN HIQISRFTGR YEHTEDNLIV HECKTICCEI LKKVILIRND
     MRITQFMKKF KNEFDLITTF KPMNKNSKKK PSMKPLEIEN PIQQFQRKRN PSDTPNSVNQ
     SHIQGDKSPL INEVFSNQLK IEEGIQDVSE QERRQISQAL AKRSQEMLDE IFFQNTIKLR
     GCLKVDVVAI FQDLTLYQNS DLVNNSFEIL NMLFTERQEI LNLLQNLQLL EDHEQIQSYF
     SMKQIQDNLS EQVEKSENWL FKYEEANIKE AVKVEINLQQ IVQIQAQKLQ GLPLPVIGIE
     QGEDTGRLLN QKQDYNQGIR QEAINFIEQL FEEDEVKNQY SQELIRNSYL YQQIIDLLNY
     DANTFTRKRQ EEGINKLNFN DTSVFIRILR LCYKILGRLV IGNKQNQILL TDQVTDFIFK
     HMKYLPQSYP HLLLDPLIEQ NSLLIMHEEI CRKFVKEIFN CINILKSHNI LNLVSCYLDI
     LKKIPYVNDI IVKENQTIIM DLLTSKENQN LLSFINFDDP SYKQLIHSSQ QFQNFVDSGQ
     EEIIDVPQEL DYFDSLLSLM AAVCDSKNNA TESKAQSYIS LYQLKELLIK FKNCFYVKRS
     LYFFFFHVYL DTEKEMSDQL LEIKKFIIQS IEDDLILITN NLDVQDIQLL NYKGKISLQK
     IKLEYIFESL FLCVDTILCK KLLDTSSEKQ FLTQLLESII KVSQLSVLKQ THKRKLKGIL
     IQLVVRGFTS IQKLKQHNIN SQIIPNLLEV RQTQKNLQDY FSTTIQISHE STVQLSQKQA
     TLLDVIKKLK KSEILQEEIR KEFKNFVDYF TDIKYISLKA FQGLCTIEFS ELTTAMIKLM
     VQNRFVNDYD NTQNELEKKR LQVLRQIIEL ENPESNDSID LWDSLEGFEE EIIKRQNQLI
     QQGVAEMIVE IIKDPQASSD IKEEAILLGI ALLIGGNAKT QDEFLKALSS DSNNQFLGVL
     YDMITRGLLL IKKNMSKLNK QVEFKLIEEQ KQALDQQINL NDEDFDDKLS DDEAADVMDS
     QDDDEESQIP QNVIQEIRRI RRVYRLLQLF CEGHNNQFQN HLRQQIIDQQ ESGKSIDFIM
     NTTILFSSAV KYLNIHCIDL IDQILDFLIE SIQGPCVENQ ITMCRGKINE TCKDLLQKFQ
     GNQEQNKQYY ILGFDTEENK EELESLISKS FKLLYSLIEG DPSKDILQQM CQTLDFNHLF
     QILDDKFKKI LQQLNISFVQ TLNFSDEKIR KIVDRLDSHF DESLEGVFDI YLLISTLSDK
     DENVKQLLEN PPDEYVSALK FFKYNTASIE VVFKNNLIRV YFPIQPICRL LSKNSRATLM
     EEIPRSTTSE KIEGLVEATI DLFDEMEHLA FLKKQIFNFS SNRLQALMLI SYTFALAINL
     TILFTYKLTF EEFQKAKNYI NPGALTTTVV FGIIQFITVL IIILFYIIIH GPLIIKRSWH
     AIQEENEKFK KPQEEERIIE AKYLSLRDAV SVLMTKGPNA EEFWKSGKRD FGHFFVAFFY
     YWRNFQTMMR QGSFIYLLFY VIVSAMGLFV SDITYCLLLL DIIARFPTLQ NVVKAVTTNI
     RQIGLTTLLG AVLIYIYSIF AFYFSDQTYK TTEVYGLDGE KGDQNTCTTL FQCYLYTLNQ
     GLLHAAGIGE AIAKPSYEDP STFIFRYFFD LSFFMIINIM FLNFIFGIII DTFAQLRDEK
     QKKEEDKNNV CFICGLSRNE FDKVPGGFTI HIEKQHQLWY YVYYIYHLKC KDSTEYNGVE
     SYIQDLLNKQ QTTWFPLLKA LSLSKSEDQN QESQIENKFE KLKSGLKDVT SKVEKISSKK
     IEKKKNK
//
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