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Database: UniProt
Entry: Q23RF4_TETTS
LinkDB: Q23RF4_TETTS
Original site: Q23RF4_TETTS 
ID   Q23RF4_TETTS            Unreviewed;      1827 AA.
AC   Q23RF4;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   28-FEB-2018, entry version 71.
DE   SubName: Full=Cation channel family transporter {ECO:0000313|EMBL:EAR99094.2};
GN   ORFNames=TTHERM_00388350 {ECO:0000313|EMBL:EAR99094.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR99094.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662644; EAR99094.2; -; Genomic_DNA.
DR   RefSeq; XP_001019339.2; XM_001019339.2.
DR   EnsemblProtists; EAR99094; EAR99094; TTHERM_00388350.
DR   GeneID; 7838820; -.
DR   KEGG; tet:TTHERM_00388350; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    256    278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    353    372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    384    401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    421    444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    566    587       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    639    658       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    708    737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    793    811       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      242    451       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      565    822       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       44     64       {ECO:0000256|SAM:Coils}.
FT   COILED      827    847       {ECO:0000256|SAM:Coils}.
FT   COILED     1288   1308       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1827 AA;  214906 MW;  0CBFA3CDDF631413 CRC64;
     MHSQIKKIFH LQKFQSQLSQ QKSLKDKDQI TPTQKDSNNT TVQNNNEQQQ QQQLTSKKNQ
     YQQNVFRFSI NSNQQDQNVS PNILQTDKNS NLSPSGTGNG QNQNKLITQR SKLLSKQNSN
     CLLPSLSNEF NFQHKNNLNG HTTVMCAIQE QILVEQDQYV TKKRKKIIYV LLGKSKEEVM
     AKALRHLKDA ILLRPPRNAF ESNLKFGDYF LYFYEIRWTL LWRFLQKTLS YLFIIQTFLE
     PQTEADNFND QTTENYAYYS EIVILSFCLI DNVLSLYIYR PSMKNAILKI LSYIFQFSLF
     IIFLTDFIIF WHTSLIQVRF SSILRPLWLI QFHKDIQNIL KSMLRSSRRV LDIFLFFIFW
     SCFWGYIGYN LLSEYKTQLK DDIYFVFGSI GESILGMYTL ITLDTYPTII ENIIKDNPYY
     LLFFVPFVAM NLFFFLCVPV AVIFESYKQQ RALIYLKEDK ITKDALTYCF YCLIHYNKED
     FLSKDQFFNL FNAYYKNKAI RQKIDELYQI LNIDQQDKMT LYEFQDTVAL MKTSERLYNN
     SNKYWDSFRN FCNKYLYFEK ISRSHYWSYF ILFIVFSNTI ALIYYSAATV YTDNSSSLDD
     IYTNIEIFFL SVYITDVCIK MIGLGINEYF DDYWNNFDFF MAIVSLVTII GLKYIYFIKE
     TKSTKLIKIT KLQRVLKIFR SIRSIKLLSF LKLGADALLR VQKLFHKIAI CIPSVWGFVS
     TYFLISISYG FLGIFLFNTN NNPDNGNPYD KSNYTDFNSI QNALLVLFQV VAESKWTDFL
     YGYGYQTSLP LSAAYFVTYH MFSIFFFMSL IKGVIWDVFN VVETYLKEQE YDELAELAEQ
     ADSQNNVQSE LSHKQTEELN AKNHQINQEA LIQEDIQFGR VNSFRHTNLH FGQRKADQNE
     KCVADKDPIS QDKDNQNEVL VTEPVVLNFG EEEKNSNINI EKNSLLSNQE QKHPKLSNYH
     NLHINEIIKN QFDIGNKDKD DNVLEENTEE QEKESNNSSE IPSLTNKNSS SVQESKKQKF
     NFSFKNNVHF SKENTNEQTA KDLEETPAEE TGDNEDVIQK KMLSSEEGRF IVRINTFQDS
     QNSSILLIQK KDQNQNEYPP QNIENVFDEK MTESSYKLNK NNLLSLNSTS QNSPQLKPLI
     QTKSNFQTPI KNYKSHLLIN DNNILVSFDN QKDSKKINAP LSAESKANSD KTINNGNNNN
     NNNIQIIKNQ NGDQFLTLSR INYQIPSILN KKMLGSFRRS ESSNVCADKD YVVEFQFKKP
     DSDFDKYYRK RSQLVNTLVD INAQLDQLEK YLQLYDQYGL QVAELRRQRI IDKHQSINVF
     SLSKQFALQR RTYLKDNPLN INYGNRQEYL ETIEQLLGYS DDIKSFLNKV NIPSQRSQEK
     GSLKKNKNRF RKMFQNYYTA DVQNKNDKNL NSYRNNNDSK HNNQDENLNF ISISEFGDAE
     SQYPSYTAFE HQSNVEKSLN MRKEICDYTF IRLNGIFSFL LHLLSNFNHF DIKFAIQKLF
     IIEQSINQLI FGEYDEDHRI NHFKFILYSS NNKKYFMLNK EPESIDSKTE NHLQIPQNTL
     DIEVCALPSE YGPWSALSKS LDKQNQIYFI KSLFSEIEND VDKRISGKLS DMIQFMGGQQ
     YCLEDMTQYQ IEQYCSFIYP VQNIQTQQAY QSQKANQNSY NQNQSYICFI CNKQKRKFID
     KKSDKQKKKL DIHKTFQTQL SNKGAENLSN SNKIDKGNNH NQDANKEKTN NTPKIIISPS
     SQLSNSQKVK AEEENRKQSI FSRQNQANIT KSYNQKNKVI FKKDQEHIIK IYSQIQQFFF
     THCHLLDQII QKLSSQISQE MPNYEYK
//
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