ID Q23TC9_TETTS Unreviewed; 676 AA.
AC Q23TC9;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Ibr domain protein {ECO:0000313|EMBL:EAR99777.2};
GN ORFNames=TTHERM_00666530 {ECO:0000313|EMBL:EAR99777.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR99777.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662636; EAR99777.2; -; Genomic_DNA.
DR RefSeq; XP_001020022.2; XM_001020022.2.
DR AlphaFoldDB; Q23TC9; -.
DR STRING; 312017.Q23TC9; -.
DR EnsemblProtists; EAR99777; EAR99777; TTHERM_00666530.
DR GeneID; 7842493; -.
DR KEGG; tet:TTHERM_00666530; -.
DR eggNOG; KOG1815; Eukaryota.
DR HOGENOM; CLU_420105_0_0_1; -.
DR InParanoid; Q23TC9; -.
DR OrthoDB; 180516at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20335; BRcat_RBR; 1.
DR CDD; cd20336; Rcat_RBR; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22770:SF13; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22770; UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 545..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 323..526
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 327..376
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 78850 MW; C1A5889E9199730C CRC64;
MSNQLFLHNK LHSQKASGKV GNGEFNENTS FSEIIAESGE NRFFSNPNNN NNINNNRLAG
QTKDETNVES SHNLMQKPNQ MQQDIKFPLY SFSNSQLPGF VQHNQQQQQS LQVIPGQQNQ
TFRIHYKSLL SESQESIQKE KGSLKDDRSI NQNLNQLQPY IDKQNQLTRS QNLIKQLKLK
PVQYELYKNL KEMKVKSEIA FFILVSENCM SMEETLSFFT TDEENQHLHF FLPRSNINDD
ICEICLSSKR MHAKNSLENI NTALSIRQYI RELSQQDCLE NADIKEMLSQ SEKDVNMNLL
NQQTLQLNTF QVQMSPRSPL RKRTMTCQIC YNQVDESSML YFNNQNHEIC IECFRTYLSE
EIMISKIENL KCPHCSCTLS EQTIIDHTTA SLYKKYKIFL RNTLINKDPL KRFCPTPNCD
QIISLKDKDQ KNAKCDSCKI VICCQCNRIE HQGISCEDLL EKEIEDLTDS RDIQRCNKCK
SLVQKVQGCN HMTCSICQYQ WCWLCGNTYT KIHMMPLNPF GCPFLQSERF TVKNMQMWKI
YLLRFFTLIA VIILLPFAII FSGPILALYG YFEIMNRYMY INMHTNSLFK KFIILLGGFL
AFILGFLLDP LILISIIPLG IYVLCIQIHE KNRIEAISNL RLRELQQRNE SINNIQVNTH
SNQPLYENDH QVVILL
//