ID Q23WV8_TETTS Unreviewed; 364 AA.
AC Q23WV8;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 86.
DE SubName: Full=Zinc-binding dehydrogenase family oxidoreductase {ECO:0000313|EMBL:EAS00987.2};
GN ORFNames=TTHERM_00775980 {ECO:0000313|EMBL:EAS00987.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS00987.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662606; EAS00987.2; -; Genomic_DNA.
DR RefSeq; XP_001021232.2; XM_001021232.2.
DR AlphaFoldDB; Q23WV8; -.
DR STRING; 312017.Q23WV8; -.
DR EnsemblProtists; EAS00987; EAS00987; TTHERM_00775980.
DR GeneID; 7823813; -.
DR KEGG; tet:TTHERM_00775980; -.
DR eggNOG; KOG1198; Eukaryota.
DR HOGENOM; CLU_361530_0_0_1; -.
DR InParanoid; Q23WV8; -.
DR OrthoDB; 2267374at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR CDD; cd08271; MDR5; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR047122; Trans-enoyl_RdTase-like.
DR PANTHER; PTHR45348; HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG); 1.
DR PANTHER; PTHR45348:SF2; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 17..362
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 364 AA; 41360 MW; FF43C21BF0EB076D CRC64;
MAEIPKTFRA WSLLENGIEH LQLIEREIPQ NLGEHDILVR VRGAGLNPID FKQCIWGSGP
FDQQFPRSLG EDFSGIVVKI GGKVDPNHFR MNETVVFSFG GFKDETGSFG EYKVVDSRHV
NLVSHKIVQS RGEHIFTDLA ALPAAGFTAL ACVQNKLKLP IHKDPQSISN RYTRNIFVTA
GAGGVGSFIL QLLRLWRENN FDEHEKKNIR IITSCSKNNF EYVMKLGATH SIDYNVEDMC
ARLKEILEGD QLDVWIDLVG KESAQRGSDC LGFRGELVVV FESDYSPKLY PFSQTVHNVA
LGQYQFLGAP KHMKDYRLYG ELLLELYYKK QIEIEKREIK LEEVQQALIE ISEGHTRGKI
VMKI
//
