ID Q245E1_TETTS Unreviewed; 325 AA.
AC Q245E1;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Archaemetzincin-2 {ECO:0000256|ARBA:ARBA00040634};
DE AltName: Full=Archeobacterial metalloproteinase-like protein 2 {ECO:0000256|ARBA:ARBA00043240};
GN ORFNames=TTHERM_00732700 {ECO:0000313|EMBL:EAS03423.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS03423.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- FUNCTION: Probable zinc metalloprotease.
CC {ECO:0000256|ARBA:ARBA00024316}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M54 family.
CC {ECO:0000256|ARBA:ARBA00006954}.
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DR EMBL; GG662485; EAS03423.1; -; Genomic_DNA.
DR RefSeq; XP_001023668.1; XM_001023668.3.
DR AlphaFoldDB; Q245E1; -.
DR EnsemblProtists; EAS03423; EAS03423; TTHERM_00732700.
DR GeneID; 7847085; -.
DR KEGG; tet:TTHERM_00732700; -.
DR eggNOG; ENOG502QVTZ; Eukaryota.
DR HOGENOM; CLU_029710_2_1_1; -.
DR InParanoid; Q245E1; -.
DR OMA; CQWLSCV; -.
DR OrthoDB; 2719238at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd11375; Peptidase_M54; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR012962; Pept_M54_archaemetzincn.
DR PANTHER; PTHR32205:SF5; ARCHAEMETZINCIN-2; 1.
DR PANTHER; PTHR32205; ARCHAEMETZINCIN-2-RELATED; 1.
DR Pfam; PF07998; Peptidase_M54; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 38302 MW; 471D535A16E9D905 CRC64;
MQKKQLFSQP TQQQREKALG DLSSLSQKNQ TQIKKIIGYF KPVPNPYSDD WLYNQKEEGQ
TFDKYIEKPR TIDTKKRKIY IQPLEQDINK EFVDKLKIFA SAFFFGIKVD FLPLLEVEKL
GVKTRINENK KQFYAPKILE LLKESKPKDA YCIIGICMTD IYNKESWNFV FGLASLQEKV
GVFSFARYQE SFYYPKAQVD QDLVIYRSCK VMCHEVVHQF GIKHCIYYHC IMNGSNHYEE
SGSKPFQLCP VCLRKMQYAL QFDLADRYRA LIQATETLKN KYFSQELFIY KNLVLNENLV
ISESSSKLQQ NQFEKSNNKI QSNNK
//
