ID Q245U2_TETTS Unreviewed; 991 AA.
AC Q245U2;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=DENN (AEX-3) domain protein {ECO:0000313|EMBL:EAS03541.2};
GN ORFNames=TTHERM_00245570 {ECO:0000313|EMBL:EAS03541.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS03541.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662474; EAS03541.2; -; Genomic_DNA.
DR RefSeq; XP_001023786.2; XM_001023786.2.
DR AlphaFoldDB; Q245U2; -.
DR EnsemblProtists; EAS03541; EAS03541; TTHERM_00245570.
DR GeneID; 7841483; -.
DR KEGG; tet:TTHERM_00245570; -.
DR eggNOG; KOG3569; Eukaryota.
DR HOGENOM; CLU_294160_0_0_1; -.
DR InParanoid; Q245U2; -.
DR OrthoDB; 12083at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF0; UDENN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02141; DENN; 1.
DR SMART; SM00799; DENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 723..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 478..961
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 92..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..77
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 157..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 991 AA; 114974 MW; 1BA448859441DBD9 CRC64;
MADYITDIKN KDNKISILQN LVEKNDGHVT RLKSMIEQLK KQLKFEQEKN NEMAKDMNKL
RETIQQQNLK IRELQESLFK SKESERQLQI KIKDLQSNSP LKNTKGSSTT TAAQSKNSDK
QHNEQIYNIK SMIDLTKLEE SELKHQEYER NYQESILQNK STNDQSNSPL QRSVERSQIA
QNDEISWQNS EKRRRNNNLK VDSSVLKNSS FLESPKIQRT MLSVVEEDLS NIMKSAQYQK
ELDPALLKTI AKSIVAIKYT SKVMESSTCS IPCVSEQGDE CNEMHIDKNY NADRILTNED
KNSLFHIKLN EVEQDELNSI EVRKKKSSSM SDKASRRISF QPKGIHYHNH HGNLKSNNSQ
LTPTSQKVSS NGIINTNQSD NQQQSTRQKG SSTPRIDTFD NQKQQESQTS LGSQNQTSQN
GAGSLRNNQI QDEDIIEIKE SMVSGVYSES TSGSNSPKCS EDADMYQPFS HFFVLGCDKD
DVKEFDKMGV DRVLLPGKLL YNYSDRVSKS KNDPFEIVKK QVSEYAFPYG LEVKKIDGDM
GQIKQIIIPP TKHGMNDKFF FFKMRSQENF KQVQVEKQKN DLLKIVNPNK VLFFTCLQIR
DFIEITSDDD TQKKSYWRVQ KIFCFVSYFP FYDLLSRLLQ IVQDSIKVER QFVMLNADNF
TELDKIDSDS VQLHISKNIE QYLQQWQRTE LRILGKEYKF SMDQQGFFQY NLPSHPDFRK
KSLSWSLIGP ISCLSFQNFL FILFAILQEQ HIIFVSTNLC LLTKAIACFE ALIMPFQWPY
PIVYTLPENL MGLLGSPQPI ILGINRSGRY VLSQDLVESN PDHIFVLLDE GTILTNNNNY
VKQYQKNPPS LSLKQQLAED YSRVGLSLND ALKVYNQAQY QQFNSSEQYK RSFPIPKFHV
KNDEIVVLEN IMQTCFNIFQ QKIISLLPKQ PIYDSDEQLL DYDKIKSIIL QQSSEEDKLF
LNNFCSQSSQ IFLYFCEDFY NLVEDNNMKE H
//
