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Database: UniProt
Entry: Q248C2_TETTS
LinkDB: Q248C2_TETTS
Original site: Q248C2_TETTS 
ID   Q248C2_TETTS            Unreviewed;      3243 AA.
AC   Q248C2;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=MIR domain protein {ECO:0000313|EMBL:EAS04123.2};
GN   ORFNames=TTHERM_00532470 {ECO:0000313|EMBL:EAS04123.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS04123.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662455; EAS04123.2; -; Genomic_DNA.
DR   RefSeq; XP_001024368.2; XM_001024368.2.
DR   STRING; 5911.EAS04123; -.
DR   EnsemblProtists; EAS04123; EAS04123; TTHERM_00532470.
DR   GeneID; 7840786; -.
DR   KEGG; tet:TTHERM_00532470; -.
DR   InParanoid; Q248C2; -.
DR   KO; K04960; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2832   2850       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2883   2903       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2954   2978       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2999   3022       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3081   3099       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    206       Ins145_P3_rec. {ECO:0000259|Pfam:
FT                                PF08709}.
FT   DOMAIN      718   1001       RYDR_ITPR. {ECO:0000259|Pfam:PF01365}.
FT   DOMAIN     1647   1784       RYDR_ITPR. {ECO:0000259|Pfam:PF01365}.
FT   DOMAIN     2392   2487       RIH_assoc. {ECO:0000259|Pfam:PF08454}.
FT   COILED      142    169       {ECO:0000256|SAM:Coils}.
FT   COILED      672    699       {ECO:0000256|SAM:Coils}.
FT   COILED     1665   1685       {ECO:0000256|SAM:Coils}.
FT   COILED     2186   2206       {ECO:0000256|SAM:Coils}.
FT   COILED     3187   3207       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3243 AA;  382839 MW;  3B929914919C9DDA CRC64;
     MHTNQEFNIE DYVDDEQSSS NFQPQEDYEE KVVLKYGHTI HLQLSEISDC SLTTDGFMNP
     KLFIEKISFS NQDKALFMIY PSFNTSNLDK LSQLPLMKPQ EKKNFEKRVI DDYKQNLDIF
     EKMKGLPVVF DTPLQLLNIN TNKFLSCNYH EAEEERQNFK LELQNFSSKN TLFKIVPSYI
     HQDQKDGVVF SNDVIFLVSA EKYLERNPYI QCNTQQYKKY MQSVMTSQHL NRQSFFQRSP
     SIIKKSKQEN ELPFSSNQMA QKFDRASKMM FVQTETKTLE MGQEIISENK LDIIKPKPLI
     NNQTSNKSGN QTVQNNQEDL NQSSELKSGQ DNNQNIHETI RPNQVHKFKK EVDLKGGANQ
     ATILPSIDNP NIIQLNNQNI IPVNPSPVFP QSQFQDQPLT LNKFEENRNY QTEVNVSLEN
     KTKWVIKSYC EVHKDEEVIK YGDKIWLHHL ETANNIVTQR NFIMKQEIQK QFHLENDEHK
     QDQNRYRQCV KFETTTIKDS TFSKHTGNTK GMWIIERKQK LKGGPAEFKQ IVFFKHFSSR
     KYLQLVKFPC GKDQYAYYFD LADEPNLSCS FVLIKLPSSG TKNQKYITKE SFFYLKSVEF
     KVYINVSFRK GNTNLEEYLG FNQGVDVSEI QIDEAAFKLD KATNSEVLET YFLTQCLPIL
     SKNLDTFQIQ QKRNATNRLD QKNKENVILL NQLEQTIEDI KLFCLNQIIL TSIENQRNYS
     KVSFYRQKIV QEQYIIDELI EILKCIVKES DLLKLRNERK QESYKKAQIK FSDKTLQNIE
     KLKKAVLKEK GINLNLYLSK FGKMSFVNNE QGKAFFFAIG KFEEDRVQAR AKYLQDKIHV
     LKKIYGLLTI VIKDNTDNVN LIYRKLTQFQ NHAAYIKEAA DFVISIVSQN ETILSNLSDD
     IKITESLDNL LTRAPSLKIF FQTSDQAYRR DTYITPLGDI PRKPTDNLLL FFKENAITQH
     KENLKSKLTH MKDPNILNFF RNICKFQGKG VSVNQEQIHK FCFENEVPTD FYRSLFYKLE
     GEEKRLKLDL NGRIIQIASQ KDLEDVSPDI YGYVIDQINL CADLCLTRNY LWKKDLKGFF
     PVEFVFKVIF DNSVDEKLRS AFCNLARSLY VDHEPLNKKQ VPNMCRIFRG LETAKKFNKD
     EEEDDHNDNI IYAYTIDKII RYINQQYIKL RKSYEEFSDQ ELNKKALKSL KKEEGNDQDK
     QNPVVFDDGL TLDIIKMLTT FVKFDILALL KQQYMYRSIV TTLLQLLEYD KNQSHISYVV
     QKVRQERFNR AFDDQNKNKL LSNFTGFIVS ASKNIAQAGK EIAGEVAGIV GAMIGVSYGK
     SSEEADNEQF EATNSLYAKN PMIGGLVTLK SMFQKVYSET EDQIEVEMKT EICELFIFQQ
     NSRMDFLITN FLCWYDQVSK KYTDFSNKKV AAEIEDDIPT IIPELYKTGV DEIEMRIMQM
     TENLDLKLNF DITNMTNMLK LKKKKKFQNY TSLELVLNLD SLLEGDLEKI IQKEKSQKQR
     NNWQANLENP QDPANSIKQE VLPSLLFSFY MTKNHKVEDK VIEVLRNCFN QTNILFDNLY
     NLEVLFDQRD VVPYILLDQK IAKLRQFAEE SEVWLTDFLR TQQVPDRMKQ TQIILNEINE
     LFYYDVNIVD DKIVIPAHKI SSEEKQTRRQ IDKVRQKVFT FLQGHEHLIQ LVKDAQNQMA
     KLLKSKNVSN PSKYSIYKLL SSLYRCLTLY CDNYEENQQI LSKYTGFFLD EIQFDFGQLD
     LVCSIYKNNK HLCESFSDNI ANVLINNITY IGRQPRFLKL FKIILSYKEK NNRLPTNLIE
     NQMKVIHWFL PKDNQDKNEI QRYQQLLYCT IDQKNKQSVQ FKFEKQQEKS DVQLRDVPYH
     YHAELLDLFL QSVKGDESSS INTSKLKKVF PQSYILDLLV KEDSFVPSDQ MYQTFKMPKK
     NDKKLNVYIY DNTITYDVDD EKEGFKILKP KLIDFLLAIY FNEDKPYSDS IKDHKRFYQL
     CEMEYQRLSR QIDQFPQDYI HYICGKILKT ALFYFKKVIL RENQQDYKDQ DEYKILYNIS
     TRLFEIRFQF DELLNKQEFQ DYAEFMKNIN EQCYNQYTEQ INAAEMKPDN KKNEYDEENK
     LLWKAQYNWK IFLSICRNSE LVKDTIETEI SILAESILKI KDMFPEQYRK QFKIDIQYQD
     IIKKLIQYLY TGLVNQAHID NMIFIFNLLE QMLNDCEEDK QLEETQNLFD SLDATKMCLH
     LLSDSKKNPI EKKELLDSIL QFMIKLLEGG NGQVQKTIYD YFMTYPESEV IFHLFYSIII
     DYIQDVKDKK KQEILKIQNE MLSNIDQFSG INQSLVQSKR GMSQVKSQSQ NDEVLESKQK
     SKSFKQPLKN QAQKSKVTDD IDNESILQNS QAELKFDDDK DPHRKQIKMI NSHILMNVLR
     VLQLFCEGHN INLQNYIRDQ TNSRNKHDMV TAIIDLLYIF YDNIDEENFS NMLKCLDTLI
     EFVQGPCKEN QNAIIDSKFF QFAEEILEGY DQKKHEKKRL TYFQSSNMLN QSMNSFTRSF
     AQRSSTKTKT ILSHIAQKSN TQLKPWMLEQ IKYKTMILVT SLLEMNSEPQ VIKRIMRSLP
     LEVLRKNLIQ VYKMHKKLYQ EQYIIQCFGH HEDEPPEDAT EKQLEYYNYI IETGFFVFFL
     LSYYIELDEK ELDAEISTKL NEIKKDFNDS KSIFSLRKGM ITQIYNLIYG IIDSILDIFK
     GIGNEIKNQI TSKNEEQTVD YEKQMREDNQ MFKQALAFFN KNSGSIEIVR DRNLERIRFI
     LLPFCHYLPK QTKVQFHDEI DRDSIHTKLS DLVKKAPEII EICKHEEQLS LFFNRNKFIG
     IFANSVDLWR DIAFLLTILI NIFIVVSYGG GEYSTAEEKK HNQLWSPSLG LDNSVTAAKT
     EQIFRTTGII MIVCSSFVVL FFLCQKAPLY LKRAWESQKA SILQEKQMLL IKYTKYLIII
     LTSILKVLTN PEVIYYLMYG TLAFIATYVH PFFFSFHLTE CLLRFPTLRN ILKSVSDSYA
     SLILTFVLII MLFYFQAVIA FFEYYQDYNS QCDQLYLCLF HTFLMTFQNN GGIGGYLESN
     VSNLQMSGHS YDYSRFLFDN ISFFSVMLIS VQIFSGVIID KFSYLREKEY EKNEDIFQKC
     FICEHSRELF ERQSDFGFEQ HIKQDHYLWN YVFYLAYLSY KDKTDQSGIE SYIQSQIDEG
     SDNWFPIEKA LILKDNKDED QEEMERKKSF KLESDIYYKQ IQEVLQNQQL LQEIVQTQKQ
     YKK
//
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