ID Q24CU0_TETTS Unreviewed; 775 AA.
AC Q24CU0;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 3.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Tetratricopeptide repeat protein {ECO:0000313|EMBL:EAS05668.3};
GN ORFNames=TTHERM_00713620 {ECO:0000313|EMBL:EAS05668.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS05668.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the APC3/CDC27 family.
CC {ECO:0000256|ARBA:ARBA00038210}.
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DR EMBL; GG662338; EAS05668.3; -; Genomic_DNA.
DR RefSeq; XP_001025913.3; XM_001025913.3.
DR AlphaFoldDB; Q24CU0; -.
DR STRING; 312017.Q24CU0; -.
DR EnsemblProtists; EAS05668; EAS05668; TTHERM_00713620.
DR GeneID; 7825170; -.
DR KEGG; tet:TTHERM_00713620; -.
DR eggNOG; KOG0591; Eukaryota.
DR eggNOG; KOG4626; Eukaryota.
DR HOGENOM; CLU_020511_0_0_1; -.
DR InParanoid; Q24CU0; -.
DR OrthoDB; 204321at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00180; PKc; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR PANTHER; PTHR12558:SF13; CELL DIVISION CYCLE PROTEIN 27 HOMOLOG; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00515; TPR_1; 9.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 12.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50005; TPR; 12.
DR PROSITE; PS50293; TPR_REGION; 8.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 27..300
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 338..371
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 372..405
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 406..439
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 440..473
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 474..507
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 508..541
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 542..575
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 576..609
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 610..643
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 644..677
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 678..711
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 712..745
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 775 AA; 89980 MW; 6A7C14D6EAA13A19 CRC64;
MQQEQDSEPL KKLQKLAQQL EQNKQLRVID LDGQKGSFDK IIIAENLISK SQQAIKIISI
FDGIDQVSQK KLQDAKKEAL FLKNTNHQNI VKYCDEFQIG FNYFIVMEKC EKNLQQFIED
FKSQETEIPK HIIVNFACQI LSVINYLRQQ NLVLRDLSLR NILIDNHNQI KLYDVGLVKQ
VQEEFTFSLI LTTFPKRSLF YYPPELFEQF EMSGEQNKKD QFKNLLDGDI WAFGICLYAL
AGASQQEFSS LKSKGYQKLT SLDKSLNSIL SQILSLDPNQ RPSILQLIDT FEDMRKQIWT
SDDSADLFQR FLQKKKAHQW YLAYQFISIC CQIQQNNETY WHYLGYTQNE LNFFSESIKS
YQKCLEINPK KDICFMNLAI AYKEKGMIDE AIKSYKKCLE INPKEDSCYY NLGIAYKDKG
MLDEAIKAYQ KCLEINPKKE ICFYNLGIAY KAKGLIDEAI QSYQKCLEIN PEKDTCLHNL
GIAYKAKGLL DEAIKSYQKC IEINPKKDIY YMNLGLAYME KGMLNEAIKQ YQKCIEINPK
EDSCYFNLGI AYENKGMSGE AIKSYQKCVE INPQHDSCLY NLGIAYKAKG MLDEAIKSYQ
KCLEINPKKD ICLYNLGIAY KAKGVYDEAI KSYYKCLEIN PKHDNCHMNL GLTYYDKGML
DDAIKSYQKC LKINPKHDIC YMNLGIAYKG KGMLEEAIQF YQKCLEINPK KDSCYYNLGI
AYKAKGMMDK AIQSYKKCLS LNPNHKNCLK NLEIAQGKKN DRKIIEINQP FLVLN
//
