ID Q24DG1_TETTS Unreviewed; 3300 AA.
AC Q24DG1;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=PHD-finger protein {ECO:0000313|EMBL:EAS05817.2};
GN ORFNames=TTHERM_01232260 {ECO:0000313|EMBL:EAS05817.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS05817.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662327; EAS05817.2; -; Genomic_DNA.
DR RefSeq; XP_001026062.2; XM_001026062.2.
DR EnsemblProtists; EAS05817; EAS05817; TTHERM_01232260.
DR GeneID; 7835472; -.
DR KEGG; tet:TTHERM_01232260; -.
DR eggNOG; ENOG502R6ZQ; Eukaryota.
DR HOGENOM; CLU_225625_0_0_1; -.
DR InParanoid; Q24DG1; -.
DR OrthoDB; 180653at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15489; PHD_SF; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 487..538
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 354..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1817..1891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..1973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2067..2280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2317..2354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2375..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2418..2453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2731..2801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2823..2864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2919..2990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3008..3249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3278..3300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 762..793
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1091..1124
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1283..1310
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1452..1506
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 873..894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1528..1571
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1572..1587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1817..1834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1848..1889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1954..1973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2067..2136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2149..2239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2246..2262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2743..2774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2919..2936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2944..2958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2966..2990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3008..3042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3057..3124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3135..3249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3278..3294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3300 AA; 384092 MW; 91588E4108539FB5 CRC64;
MNWSQKLSKK KKQINKQQKE EEKQYQIDFN KYKKINRNSL LKNQIKQRKI YIDCYIDYTY
LQRIHKQIME EEKQIDNNQK LEESNFKVKF TRLSNYQDYQ ESYCEVCFQS NNKYYPENDE
KGIKMMVCYG CSLKCHAYCY GIDTQTQEEL IKKKQDQKVL YFLCQKCRIE PKKPIGCVIC
NQKKGALKKI ENSQTNEWVH ITCGFYNKGI VKIDNYRTMA FVKQSDAPIE KDKKAKKSCH
FCKSDVGIER CVTDGCQQHA HVYCIMNYVR EKEKAGADPL DIKWFARMNY VNNVKFDISK
GENETSNLSK NVYFQQSMKH SFNEISQILL GEPIYQLENA ASFESAEIVP AEQKQSKISS
AKKKGKRKLS EDETQDQNQE NTNFIEETQQ ATKITKQNKI EYQSKLVELG NLVMKNFVLN
ATTASSIQEE QVVAAAKMNS SALKKSAKND KIQNSDKATQ DSQNSDPEIY LRGGEMYIEC
PDHRRIDVYC VCQKADASDD MVYCDLCNDW YHYSCVKYNP DKDDDSSGKY RCTMCEDWYN
HKKKKLLKEF QSGKAETTNI LIANMPKFNL MDFISVIMIT DQRIQNLLFN QKKGNIDSQI
NEAVKFLSYF PLFSSKIQEI TVFKQRKYLH QAVNDFLQKI IEETELLKIV SAVQIDEKSP
AKYIVLEENL KKNEELKRLI DGISALFQRN KTKEKGILLN LKKPINWILK VHQVFFKKQE
KISSLILQEL MKDEEDDVKN TVEYQLLDQY AQRLKSWNAK VNSFYENIIQ KANSKMEEEK
QSAENTEKKQ VEEDEFINLK YQLWRDRLST RPTIEELEQI LEEGREIPVD CSQDIKKLES
EKDEVQIWFQ TLDERERSAN LLLTQKLKQE ERINKSSHIA QNDQDGESKI KKENNTQSIS
KASLQEEQAQ EQQMNNQNGE KIQVEEEQNQ QQKQENSEDP KINEEKSNEK NENQNEAGVK
DQMDNEENEQ NQKGEQKQQE KMNEENNNAK DQQNTAMEIE KNSEKTDKKG EEHKENHHKQ
EQESQAEGGK GHVDNLTHQK IYKNQQLMSK GDFEIFANQM FTKVVLQVPR MNQIIDMLQQ
YEVNELQWER LLEFINEKEQ ENNAKKQQQE LEQNQQQDEF IQQQIILSQY QNNTSKYELI
EFQELKDLLE SCLKLEIKVP FLNQIVQQMN NYLEQKAQFQ NVLNSQFDES NYFQQLKKIL
TLPFIFEEEK QFYERIVYFK EIQEICKSGF KKFYSVEQIQ KLSEICQSSK FSEEITSEFQ
SKTENICQIA KGLNKIVETG LIEKEQLDQA KELTEQISQM KNSKVDFKRE LEILKSIQKS
VQWFRSLHKF FFNLNEDQIK LDPSMRVQEI DLEIEDMLEA KNIDECEADI QEKWNLVCQN
LNQVKGELYS FIKEGISTEY HHDKRISKIY QNLCEMCWIY EAKLLLSLQD VKFQQVFEML
QTGLNFKINQ ENEIFKKVKE LLESTKKKHE EEMQLRQQHI QEMQKQQQEQ LKFQQLQQQQ
QSLQSKKINL VVSDDSGNEN GSQKSDWDKD EDDEEDGQDE EDEDEDEEDE EDDDEDDDDD
DDEDEDDNDD DSKTDKDGRD DNNDDDGNGR NNNNQKGNQK KTDLIQIESD LSLMDEEESQ
QQQQQNESDT NNLNEVQRNQ YKTLFEQGLK WKNEVQSAYQ IIKNCSSSDS GENNNKMDIE
KLSDDSLVTF QQLKNLLQEG YQITQDILKL HQSVVFMKSK MIKLENIFIS IHKHLDQFNK
IKNPDLVDDS VKIQNCIDIS DILIEYKVNL SSNSQEKLSF KNMIKFPFRN LNKFASNYKR
EEDLSYFIKE TTNESSKQIQ ATSSQQGSKQ SRKQQAKLQE QKQRKQKGNV KQSQVIELES
QENNQETNNN DSKSEKSGQQ VTGLRQKSTR NKTKLIDSDY VYFTKHQTKE ETVAAENKQK
QKAKQNNKQV SENSKKVAES QEENSEDEGD DDHDSANLEQ KAKPEQVSDG DRSKTLENLK
KTFMQNEVFS KCLNNIKAIE NQLFGELNKD RKKYLIKAQQ FTNLFSKLSA YPQISKKLVS
KGLQMSSLEK LMNQQDSRLE AIEKQINNQQ VQQQESSSAA QNNPKSTQPS SNNKNAQSAN
LSNNNYNQTS RNSSQQSAQA SSQLQKNLNS TKEPQLQKKI KQFDPLPSIP GITSGNNASS
QNAQQSSSSS HNSNSVLSML IQKNDSSKSN NNTNSGNNNT NNNNNSNSNN NNNNNRQKDN
NKYNSNSVNN SQNSFQNKFK EDQQNKKNNQ NYQQTNNRKR RNQQANFSDE SENEEIQSKN
VAQQELSKDL YKGRNQSLSF DDDIKINKKS TFIDFENKKQ EQKQQSPQSF SQSHQSTNED
KQTPKSSINK QDDENIEQIQ NIFNSESKLY TFDKASNSNQ QSQGTELLYN PDEEEEGVQG
GEVEMDIQKI NQQYFDFDYD QNPAGTLSET NQNNSNNSNN KVNNNQQNNS SINYQNDAEK
DNLYQKNSSS LKQKSDSFTN KEAYQNQMEE ELDVPIPEDS IVRICSSSIK PQKNMDSIKI
YMHTLEPIKK LNQFPLTQLI QNLEVKCAYT GFDDVNSYIS TYTSRSKSKP QLMVMKGWIE
VQNPKKDSEN FLQLIKQQDE KKKVLGYKIG SVFFNVFTES QIKKTDYKFD IKPFNSDNAA
VQYFVITKKM SEPKPDEPNN YEFVKFCTNL NPPNSLQGIS PIISDNEDDE NIMSKRDSIF
DDKYNEDSQQ DLKLDIIDFN QIQQQIQELP TADVPQPSLD DKQPSFDHLS QPHSYQAHGH
HQQQPYQGQY NSYQRQQPPP PPIPQINQQG FPSNIPIVPP SQMPFNHSNQ SFSNTMPNYN
LNSTPTHMQM GGPHQQQQQP HHHLHSGNPI NYNQQVPPQQ IAPSPLVQNN MSIEQQDNEK
KDLSHDLNDI SNSQMINESN LELFDFDDLD QLKMLLENDN AGTPSAQSST LQSSQPPTVQ
IPPPQQQYHK MGSNQKQPPL PGQAPPFMHS NQTQGNLNES GSAQNQNPNI DPNLQQLIIS
QRSKPAYEMN PQIQPPFPNQ AQQQQQPPQT QPNYQNKPYP PQQQQNLIPP PPVPHQIGNQ
SQMQPSHPQQ YHGHQQQGHM QGQQWNQSNQ QGNSQYIRNA PNQNKNPQYG MNNQNSNSYQ
KGMPNIPPTP HPGQMPNQQQ NMNLQNYNNQ NMGRQYSHNP QHNQNSNQSG ANNMNRQPRY
NNNNNQGYGG SQYNNNNPNN QNQQQQNYNK FQRGNQNAMN NNNNGNTPNK GGHGYQQHKN
PFGSRQQAHY QRNNQPYTAH NPVPFQDPNT MDNQLMQQQQ MQYHPQQNDN MGDLDQRDYS
//
