ID 5HTR_LYMST Reviewed; 509 AA.
AC Q25414;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=5-hydroxytryptamine receptor;
DE Short=5-HT receptor;
DE AltName: Full=Serotonin receptor;
OS Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Lymnaeidae; Lymnaea.
OX NCBI_TaxID=6523;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8093556; DOI=10.1073/pnas.90.1.11;
RA Sugamori K.S., Sunahara R.K., Guan H.-C., Bulloch A.G., Tensen C.P.,
RA Seeman P., Niznik H.B., van Tol H.H.;
RT "Serotonin receptor cDNA cloned from Lymnaea stagnalis.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:11-15(1993).
CC -!- FUNCTION: This is a receptor for 5-hydroxytryptamine (serotonin), a
CC biogenic hormone that function as a neurotransmitter, a hormone, and a
CC mitogen.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; L06803; AAA29290.1; -; mRNA.
DR PIR; A47174; A47174.
DR AlphaFoldDB; Q25414; -.
DR SMR; Q25414; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15331; 7tmA_5-HT1A_invertebrates; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF191; G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..509
FT /note="5-hydroxytryptamine receptor"
FT /id="PRO_0000068987"
FT TOPO_DOM 1..99
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 100..122
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 123..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 133..154
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 155..169
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 170..191
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 192..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 211..233
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 234..259
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 260..281
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 282..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 433..456
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 457..465
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 466..488
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 489..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT REGION 323..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 168..246
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 509 AA; 56902 MW; D283696C8C50B1B8 CRC64;
MANFTFGDLA LDVARMGGLA STPSGLRSTG LTTPGLSPTG LVTSDFNDSY GLTGQFINGS
HSSRSRDNAS ANDTSATNMT DDRYWSLTVY SHEHLVLTSV ILGLFVLCCI IGNCFVIAAV
MLERSLHNVA NYLILSLAVA DLMVAVLVMP LSVVSEISKV WFLHSEVCDM WISVDVLCCT
ASILHLVAIA MDRYWAVTSI DYIRRRSARR ILLMIMVVWI VALFISIPPL FGWRDPNNDP
DKTGTCIISQ DKGYTIFSTV GAFYLPMLVM MIIYIRIWLV ARSRIRKDKF QMTKARLKTE
ETTLVASPKT EYSVVSDCNG CNSPDSTTEK KKRRAPFKSY GCSPRPERKK NRAKKLPENA
NGVNSNSSSS ERLKQIQIET AEAFANGCAE EASIAMLERQ CNNGKKISSN DTPYSRTREK
LELKRERKAA RTLAIITGAF LICWLPFFII ALIGPFVDPE GIPPFARSFV LWLGYFNSLL
NPIIYTIFSP EFRSAFQKIL FGKYRRGHR
//
