ID KRUP_MANSE Reviewed; 76 AA.
AC Q25515;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Protein krueppel;
DE Flags: Fragment;
GN Name=Kr;
OS Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Sphingini; Manduca.
OX NCBI_TaxID=7130;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Embryo;
RX PubMed=8022829; DOI=10.1073/pnas.91.14.6634;
RA Kraft R., Jaeckle H.;
RT "Drosophila mode of metamerization in the embryogenesis of the lepidopteran
RT insect Manduca sexta.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:6634-6638(1994).
CC -!- FUNCTION: Krueppel is a gap class segmentation protein.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed initially in the central region of the
CC blastoderm embryo.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; Z30278; CAA82952.1; -; Genomic_DNA.
DR AlphaFoldDB; Q25515; -.
DR SMR; Q25515; -.
DR EnsemblMetazoa; XM_030172343.2; XP_030028203.1; LOC115445865.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035282; P:segmentation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24384:SF189; DEFORMED WINGS-RELATED; 1.
DR PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Gap protein; Metal-binding; Nucleus;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN <1..>76
FT /note="Protein krueppel"
FT /id="PRO_0000046997"
FT ZN_FING 11..33
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 39..61
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT NON_TER 1
FT NON_TER 76
SQ SEQUENCE 76 AA; 9105 MW; F14B3454B876E1F3 CRC64;
HERTHTGEKP FECSECHKRF TRDHHLKTHL RLHTGEKPYS CPHCPRHFVQ VANLRRHLRV
HTGERPYACA RCPARF
//
