ID Q26586_SCHMA Unreviewed; 223 AA.
AC Q26586;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=Vesicle-associated membrane protein 7 {ECO:0000256|ARBA:ARBA00039269};
DE AltName: Full=Synaptobrevin-like protein 1 {ECO:0000256|ARBA:ARBA00042194};
GN Name=IMP25 {ECO:0000313|EMBL:CAA54425.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|EMBL:CAA54425.1};
RN [1] {ECO:0000313|EMBL:CAA54425.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Puerto Rican {ECO:0000313|EMBL:CAA54425.1};
RX PubMed=7519444; DOI=10.1016/0167-4781(94)90178-3;
RA Markovics A., Ram D., Grossman Z., Ziv E., Lantner F., Schechter I.;
RT "Cloning and characterization of the SmIMP25 integral membrane protein of
RT the parasitic helminth Schistosoma mansoni.";
RL Biochim. Biophys. Acta 1218:273-282(1994).
RN [2] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [3] {ECO:0000313|WBParaSite:Smp_055870.2}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_055870.1,
RC ECO:0000313|WBParaSite:Smp_055870.2};
RG WormBaseParasite;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00037875}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037875}. Cytoplasmic vesicle, secretory vesicle
CC membrane {ECO:0000256|ARBA:ARBA00037803}; Single-pass type IV membrane
CC protein {ECO:0000256|ARBA:ARBA00037803}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00037867}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037867}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00037801}; Single-pass type IV membrane
CC protein {ECO:0000256|ARBA:ARBA00037801}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00037845}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037845}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00037863}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037863}.
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DR EMBL; X77211; CAA54425.1; -; mRNA.
DR PIR; S47654; S47654.
DR RefSeq; XP_018644256.1; XM_018792514.1.
DR STRING; 6183.Q26586; -.
DR EnsemblMetazoa; Smp_055870.1; Smp_055870.1; Smp_055870.
DR GeneID; 8355018; -.
DR KEGG; smm:Smp_055870; -.
DR WBParaSite; Smp_055870.1; Smp_055870.1; Smp_055870.
DR WBParaSite; Smp_055870.2; Smp_055870.2; Smp_055870.
DR CTD; 8355018; -.
DR eggNOG; KOG0860; Eukaryota.
DR HOGENOM; CLU_064620_1_4_1; -.
DR OMA; NGYTYCI; -.
DR OrthoDB; 3018148at2759; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 3.30.450.50; Longin domain; 1.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR001388; Synaptobrevin-like.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR21136; SNARE PROTEINS; 1.
DR PANTHER; PTHR21136:SF168; VESICLE-ASSOCIATED MEMBRANE PROTEIN 9; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 192..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..115
FT /note="Longin"
FT /evidence="ECO:0000259|PROSITE:PS50859"
FT DOMAIN 126..186
FT /note="V-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50892"
SQ SEQUENCE 223 AA; 25382 MW; A20773334D16C0E8 CRC64;
MDLRYFAITN EKHIVWYRSF TKRSFEDVVL KYLLCNPPDQ DIYYSEGDFS LHCLTVSGLS
FIAVTDRNAS RQKFRNLVVE VSRNFLSDGT RFQRAKSGGK DCLQQSYSLN LEELMESPNS
SKGNGSLDQL RSNVNTVTAV MQENTRLALQ RGDRLNNLVS KTDELAASAN QFQTTATKVA
RKTWWENFRM KLIIVGVVGG ILLVIVIIIL WQTGVFNSKS QHQ
//
