ID   Q26FC4_FLABB            Unreviewed;       407 AA.
AC   Q26FC4;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Cobalamin (Vitamin B12) synthesis protein, CobW {ECO:0000313|EMBL:EAS19922.1};
GN   ORFNames=BBFL7_02322 {ECO:0000313|EMBL:EAS19922.1};
OS   Flavobacteria bacterium (strain BBFL7).
OC   Bacteria; Bacteroidota; Flavobacteriia.
OX   NCBI_TaxID=156586 {ECO:0000313|EMBL:EAS19922.1, ECO:0000313|Proteomes:UP000002172};
RN   [1] {ECO:0000313|EMBL:EAS19922.1, ECO:0000313|Proteomes:UP000002172}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BBFL7 {ECO:0000313|EMBL:EAS19922.1,
RC   ECO:0000313|Proteomes:UP000002172};
RA   Azam F., Beardsley C., Gaasterland T., Malfatti F., Mayali X., Podell S.,
RA   Samo T., Smriga S., Ferriera S., Johnson J., Kravitz S., Halpern A.,
RA   Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAS19922.1}.
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DR   EMBL; AAPD01000002; EAS19922.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q26FC4; -.
DR   STRING; 156586.BBFL7_02322; -.
DR   HOGENOM; CLU_017452_2_0_10; -.
DR   OrthoDB; 9808822at2; -.
DR   Proteomes; UP000002172; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43603; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   PANTHER; PTHR43603:SF1; COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002172}.
FT   DOMAIN          261..380
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
SQ   SEQUENCE   407 AA;  46383 MW;  E6C1C3BEE409B7AB CRC64;
     MMNTQSKLPV TVLSGFLGAG KTTLLNHILH NKEGLKVAVI VNDMSEVNVD ANLVRSENTL
     SRTEEKLVEM SNGCICCTLR EDLMEEVEKL ARENRFDYLL IESTGISEPI PVAQTFSFVD
     EENNIDLSRF SYVDTMVTVV DAFNFFKDFG SPETLVDRAL TDIEGDYRTI VNLLTDQIEF
     ANIIVLNKTD LVHEDTIGVL KTMIHKLNPK AKIIKSSYGQ VAPNDILNTG LFDFEEAEQS
     AGWQEELEKD EHTPETEEYG ISSFVYRSKK PFDATRFMNY VQSQFPHNII RSKGLFWLAS
     RPEQALVWGQ AGGSLKTDSA GVWWSSMPFE NRIQQYAFIE NQAEIESEWH NVFGDRKNEI
     VFIGQDMDKE KMIAVLDHCL ATDDELATKK WESGYEDHWP IERAYAL
//