ID Q27GR8_ACTS5 Unreviewed; 283 AA.
AC Q27GR8;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Putative hydrolase {ECO:0000313|EMBL:AEV84568.1, ECO:0000313|EMBL:CAJ81028.1};
DE EC=3.6.1.- {ECO:0000313|EMBL:AEV84568.1};
GN Name=acbJ {ECO:0000313|EMBL:CAJ81028.1};
GN OrderedLocusNames=ACPL_3673 {ECO:0000313|EMBL:AEV84568.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:CAJ81028.1};
RN [1] {ECO:0000313|EMBL:CAJ81028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:CAJ81028.1};
RX PubMed=10196166; DOI=10.1074/jbc.274.16.10889;
RA Stratmann A., Mahmud T., Lee S., Distler J., Floss H.G., Piepersberg W.;
RT "The AcbC protein from Actinoplanes species is a C7-cyclitol synthase
RT related to 3-dehydroquinate synthases and is involved in the biosynthesis
RT of the alpha-glucosidase inhibitor acarbose.";
RL J. Biol. Chem. 274:10889-10896(1999).
RN [2] {ECO:0000313|EMBL:CAJ81028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:CAJ81028.1};
RA Stratmann A.;
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAJ81028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:CAJ81028.1};
RX PubMed=11443082; DOI=10.1128/JB.183.15.4484-4492.2001;
RA Hemker M., Stratmann A., Goeke K., Schroeder W., Lenz J., Piepersberg W.,
RA Pape H.;
RT "Identification, cloning, expression, and characterization of the
RT extracellular acarbose-modifying glycosyltransferase, AcbD, from
RT Actinoplanes sp. strain SE50.";
RL J. Bacteriol. 183:4484-4492(2001).
RN [4] {ECO:0000313|EMBL:CAJ81028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:CAJ81028.1};
RX PubMed=11937512; DOI=10.1074/jbc.M202375200;
RA Zhang C., Stratmann A., Block O., Brueckner R., Podeschwa M.,
RA Altenbach H.J., Wehmeier U.F., Piepersberg W.;
RT "Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes
RT species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor
RT leads to proposal of a new biosynthetic pathway.";
RL J. Biol. Chem. 277:22853-22862(2002).
RN [5] {ECO:0000313|EMBL:CAJ81028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:CAJ81028.1};
RX PubMed=12681481; DOI=10.1016/S0014-5793(03)00221-7;
RA Zhang C., Podeschwa M., Altenbach H.J., Piepersberg W., Wehmeier U.F.;
RT "The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a
RT 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.";
RL FEBS Lett. 540:47-52(2003).
RN [6] {ECO:0000313|EMBL:CAJ81028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:CAJ81028.1};
RX PubMed=15808935; DOI=10.1016/j.resmic.2004.10.016;
RA Brunkhorst C., Wehmeier U.F., Piepersberg W., Schneider E.;
RT "The acbH gene of Actinoplanes sp. encodes a solute receptor with binding
RT activities for acarbose and longer homologs.";
RL Res. Microbiol. 156:322-327(2005).
RN [7] {ECO:0000313|EMBL:CAJ81028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:CAJ81028.1};
RA Wehmeier U.F.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AEV84568.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SE50/110 {ECO:0000313|EMBL:AEV84568.1};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003170; AEV84568.1; -; Genomic_DNA.
DR EMBL; Y18523; CAJ81028.1; -; Genomic_DNA.
DR RefSeq; WP_014690640.1; NZ_LT827010.1.
DR AlphaFoldDB; Q27GR8; -.
DR STRING; 134676.ACPL_3673; -.
DR KEGG; ase:ACPL_3673; -.
DR PATRIC; fig|134676.3.peg.3589; -.
DR eggNOG; COG0561; Bacteria.
DR HOGENOM; CLU_044146_0_0_11; -.
DR OrthoDB; 3180855at2; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0016791; F:phosphatase activity; IEA:UniProt.
DR Gene3D; 3.30.1240.10; -; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR000150; Cof.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR023214; HAD_sf.
DR NCBIfam; TIGR00099; Cof-subfamily; 1.
DR NCBIfam; TIGR01484; HAD-SF-IIB; 1.
DR PANTHER; PTHR10000:SF8; PHOSPHOGLYCOLATE PHOSPHATASE 1; 1.
DR PANTHER; PTHR10000; PHOSPHOSERINE PHOSPHATASE; 1.
DR Pfam; PF08282; Hydrolase_3; 1.
DR SFLD; SFLDG01140; C2.B:_Phosphomannomutase_and_P; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAJ81028.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440}.
SQ SEQUENCE 283 AA; 30086 MW; 99053573D8CA28B0 CRC64;
MDGIGTTPPR DHRVVATDLD GTLLRSDLTV SARTRAALRD ARAAGMIHLA VTGRPVIDTR
RLLAGLGYTG PAVCGQGAQV YDFGTDRLLL SRSLDTDLVR ELVRRIAQRT GPLALAAVSA
GLGTEFLVTA GFGAPYQQHR WQLVDEPDLW RAPVAKVLIR HPDHDDDTLA ALADEVCGAA
LSVMHAGPGL VELLPGDTSK RTGLAFLAAE LGFTGADTIA FGDMPNDLPM FDWAGYGVAM
ANGHPRLRDR ADEITVSNDA DGVAVVLERL PAVRAGNRKA SLR
//
