ID HPLN1_HORSE Reviewed; 354 AA.
AC Q28381;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 24-JAN-2024, entry version 137.
DE RecName: Full=Hyaluronan and proteoglycan link protein 1;
DE AltName: Full=Cartilage-linking protein 1;
DE Short=Cartilage-link protein;
DE AltName: Full=Proteoglycan link protein;
DE Flags: Precursor;
GN Name=HAPLN1; Synonyms=CTRL1;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cartilage;
RX PubMed=7574168;
RA Dudhia J., Platt D.;
RT "Complete primary sequence of equine cartilage link protein deduced from
RT complementary DNA.";
RL Am. J. Vet. Res. 56:959-965(1995).
CC -!- FUNCTION: Stabilizes the aggregates of proteoglycan monomers with
CC hyaluronic acid in the extracellular cartilage matrix. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HAPLN family. {ECO:0000305}.
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DR EMBL; X78077; CAA54987.1; -; mRNA.
DR PIR; S42938; S42938.
DR RefSeq; NP_001075973.1; NM_001082504.1.
DR AlphaFoldDB; Q28381; -.
DR SMR; Q28381; -.
DR STRING; 9796.ENSECAP00000014153; -.
DR GlyCosmos; Q28381; 2 sites, No reported glycans.
DR PaxDb; 9796-ENSECAP00000014153; -.
DR Ensembl; ENSECAT00000017421.2; ENSECAP00000014153.1; ENSECAG00000016477.4.
DR GeneID; 100034208; -.
DR KEGG; ecb:100034208; -.
DR CTD; 1404; -.
DR VGNC; VGNC:18691; HAPLN1.
DR GeneTree; ENSGT00940000159267; -.
DR HOGENOM; CLU_052285_1_0_1; -.
DR InParanoid; Q28381; -.
DR OMA; ERACHDQ; -.
DR OrthoDB; 5402504at2759; -.
DR TreeFam; TF332134; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000016477; Expressed in articular cartilage of joint and 12 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0072534; C:perineuronal net; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0010001; P:glial cell differentiation; IBA:GO_Central.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; IBA:GO_Central.
DR CDD; cd05877; Ig_LP_like; 1.
DR CDD; cd03518; Link_domain_HAPLN_module_1; 1.
DR CDD; cd03519; Link_domain_HAPLN_module_2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR22804; AGGRECAN/VERSICAN PROTEOGLYCAN; 1.
DR PANTHER; PTHR22804:SF10; HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1; 1.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 2.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01241; LINK_1; 2.
DR PROSITE; PS50963; LINK_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Extracellular matrix; Glycoprotein; Hyaluronic acid;
KW Immunoglobulin domain; Reference proteome; Repeat; Secreted.
FT PROPEP 1..15
FT /evidence="ECO:0000250"
FT /id="PRO_0000013175"
FT CHAIN 16..354
FT /note="Hyaluronan and proteoglycan link protein 1"
FT /id="PRO_0000013176"
FT DOMAIN 38..152
FT /note="Ig-like V-type"
FT DOMAIN 159..254
FT /note="Link 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00323"
FT DOMAIN 259..351
FT /note="Link 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00323"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 61..139
FT /evidence="ECO:0000250"
FT DISULFID 181..252
FT /evidence="ECO:0000250"
FT DISULFID 205..226
FT /evidence="ECO:0000250"
FT DISULFID 279..349
FT /evidence="ECO:0000250"
FT DISULFID 304..325
FT /evidence="ECO:0000250"
SQ SEQUENCE 354 AA; 40077 MW; D815CBB7816C7172 CRC64;
MKSLLLLVLI SICGADHRSD NYTLDHDRVI HIQAENGPRL LVEAEQAKVF SHRGGNVTLP
CKFLRDPTAF GSGTHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYQG RVFLKGGSDN
DASLVITDLT LDDYGRYKCE VIEGLEDDTA VVALDLQGVV FPYFPRLGRY NLNFHEAQQA
CLDQDAVIAS FDQLYDAWRG GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF
WDKEKSRYDV FCFTSNFNGR FYYLIHPTKL TYDEAVQACL KDGAQIAKVG QIFAAWKLLG
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF RAYN
//
