ID NPT1_RABIT Reviewed; 465 AA.
AC Q28722;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 08-NOV-2023, entry version 105.
DE RecName: Full=Sodium-dependent phosphate transport protein 1;
DE AltName: Full=NAPI-1;
DE AltName: Full=Na(+)/PI cotransporter 1;
DE AltName: Full=Renal Na(+)-dependent phosphate cotransporter 1;
DE AltName: Full=Renal sodium-dependent phosphate transport protein 1;
DE Short=Renal sodium-phosphate transport protein 1;
DE AltName: Full=Sodium/phosphate cotransporter 1;
DE AltName: Full=Solute carrier family 17 member 1;
GN Name=SLC17A1; Synonyms=NPT1;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Kidney cortex;
RX PubMed=1946375; DOI=10.1073/pnas.88.21.9608;
RA Werner A., Moore M.L., Mantei N., Biber J., Semenza G., Murer H.;
RT "Cloning and expression of cDNA for a Na/Pi cotransport system of kidney
RT cortex.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:9608-9612(1991).
CC -!- FUNCTION: Important for the resorption of phosphate by the kidney. May
CC be involved in actively transporting phosphate into cells via Na(+)
CC cotransport in the renal brush border membrane. Plays a role in urate
CC transport in the kidney. {ECO:0000250|UniProtKB:Q14916}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in);
CC Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000250|UniProtKB:Q14916};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=urate(out) = urate(in); Xref=Rhea:RHEA:60368,
CC ChEBI:CHEBI:17775; Evidence={ECO:0000250|UniProtKB:Q14916};
CC -!- SUBUNIT: Interacts with PDZK1. {ECO:0000250|UniProtKB:Q61983}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:Q14916}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Kidney cortex and liver.
CC {ECO:0000269|PubMed:1946375}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; M76466; AAA31461.1; -; mRNA.
DR PIR; A56410; A56410.
DR RefSeq; NP_001075776.1; NM_001082307.1.
DR AlphaFoldDB; Q28722; -.
DR SMR; Q28722; -.
DR STRING; 9986.ENSOCUP00000012050; -.
DR GlyCosmos; Q28722; 2 sites, No reported glycans.
DR PaxDb; 9986-ENSOCUP00000012050; -.
DR GeneID; 100009144; -.
DR KEGG; ocu:100009144; -.
DR CTD; 6568; -.
DR eggNOG; KOG2532; Eukaryota.
DR InParanoid; Q28722; -.
DR OrthoDB; 2685946at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0044341; P:sodium-dependent phosphate transport; ISS:UniProtKB.
DR GO; GO:0015747; P:urate transport; ISS:UniProtKB.
DR CDD; cd17318; MFS_SLC17; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004745; Pi_cotranspt.
DR NCBIfam; TIGR00894; 2A0114euk; 1.
DR PANTHER; PTHR11662:SF26; SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 1; 1.
DR PANTHER; PTHR11662; SOLUTE CARRIER FAMILY 17; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..465
FT /note="Sodium-dependent phosphate transport protein 1"
FT /id="PRO_0000220938"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 465 AA; 51798 MW; 29B33FB1EADDCBAD CRC64;
MDNQFPSRKG PCFCSFRYVL ALFMHFCNIV IIAQRMCLSL TMVAMVNNTN LHGSPNTSAE
KRLDNTKNPV YNWSPDVQGI IFSSIFYGAF LIQIPVGYIS GIYSIKKLIG FALFLSSLVS
IFIPQAAAVG ETWIIVCRVV QGITQGTVTT AQHEIWVKWA PPLERGRLTS MSLSGFLLGP
FIVLLVTGII CESLGWPMVF YIFGACGCAV CLLWFVLYYD DPKDHPCVSL HEKEYITSSL
IQQGSSTRQS LPIKAMIKSL PLWAISFCCF AYLWTYSRLI VYTPTLINSM LHVDIRENGL
LSSLPYLFAW ICGVIAGHTA DFLMSRNMLS LTAIRKLFTA IGLLLPIVFS MCLLYLSSGF
YSTITFLILA NASSSFCLGG ALINALDLAP RYYVFIKGVT TLIGMTGGMT SSTVAGLFLS
QDPESSWFKI FLLMSIINVI SVIFYLIFAK AEIQDWAKEK QHTRL
//
