ID Q28G36_XENTR Unreviewed; 493 AA.
AC Q28G36; A0A5G3KXH5;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Mex-3 RNA-binding family member C {ECO:0000313|Ensembl:ENSXETP00000048413};
DE SubName: Full=RNA-binding E3 ubiquitin-protein ligase MEX3C {ECO:0000313|RefSeq:NP_001017067.1, ECO:0000313|RefSeq:XP_012818687.1};
DE EC=2.3.2.27 {ECO:0000313|RefSeq:NP_001017067.1};
DE SubName: Full=Ring finger and KH domain containing 1 {ECO:0000313|EMBL:CAJ83991.1};
GN Name=mex3c {ECO:0000313|Ensembl:ENSXETP00000048413,
GN ECO:0000313|RefSeq:NP_001017067.1, ECO:0000313|RefSeq:XP_012818687.1,
GN ECO:0000313|Xenbase:XB-GENE-492459};
GN Synonyms=bm-013 {ECO:0000313|RefSeq:NP_001017067.1,
GN ECO:0000313|RefSeq:XP_012818687.1}, rkhd1
GN {ECO:0000313|EMBL:CAJ83991.1}, rkhd2
GN {ECO:0000313|RefSeq:NP_001017067.1,
GN ECO:0000313|RefSeq:XP_012818687.1}, rnf194
GN {ECO:0000313|RefSeq:NP_001017067.1,
GN ECO:0000313|RefSeq:XP_012818687.1};
GN ORFNames=TGas021n02.1-001 {ECO:0000313|EMBL:CAJ83991.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:CAJ83991.1};
RN [1] {ECO:0000313|RefSeq:NP_001017067.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:CAJ83991.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA Zorn A.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000048413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000048413};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000048413}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001017067.1, ECO:0000313|RefSeq:XP_012818687.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012818687.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012818687.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CR761586; CAJ83991.1; -; mRNA.
DR RefSeq; NP_001017067.1; NM_001017067.2.
DR RefSeq; XP_012818687.1; XM_012963233.3.
DR STRING; 8364.ENSXETP00000034173; -.
DR PaxDb; 8364-ENSXETP00000048413; -.
DR Ensembl; ENSXETT00000048413; ENSXETP00000048413; ENSXETG00000022367.
DR GeneID; 549821; -.
DR KEGG; xtr:549821; -.
DR AGR; Xenbase:XB-GENE-492459; -.
DR CTD; 51320; -.
DR Xenbase; XB-GENE-492459; mex3c.
DR eggNOG; KOG2113; Eukaryota.
DR HOGENOM; CLU_025598_0_0_1; -.
DR OMA; MECANSI; -.
DR OrthoDB; 50983at2759; -.
DR TreeFam; TF315107; -.
DR Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000022367; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22423; KH-I_MEX3_rpt1; 1.
DR CDD; cd22424; KH-I_MEX3_rpt2; 1.
DR CDD; cd16722; RING-HC_MEX3C; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047228; KH-I_MEX3_rpt1.
DR InterPro; IPR047226; KH-I_MEX3_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047227; MEX3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23285; RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23285:SF8; RNA-BINDING E3 UBIQUITIN-PROTEIN LIGASE MEX3C; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 442..482
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 365..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 53120 MW; 5A088C318BFBD49C CRC64;
MPGGASWRAG AELLLLEPEE MRLRLAALSL EEEEEERPGE EVAEDAAALL MGGAGCQAGF
PPGSAEQAGR RKSVNTNELV PVPSSEHVAE IVGRQGCKIK ALRAKTNTYI KTPVRGEEPV
FVVTGRKEDV AMAKREILSA AEHFSMIRAS RNKNAPAVGN VQCAPNLPGQ TTVQVRVPYR
VVGLVVGPKG ATIKRIQQQT HTYIVTPSRD KEPVFEVTGM PENVDRAREE IEMHIAMRTG
NFIELNEEND FHYNGTDVSF ETGNMASAWL SAHPTAPGRN RMISNYRNDS SSSLGSGSTD
SFFGNSRLAD FSPSSPFSAG SFWFGETVPP MGSEDLSDAS AFDPIPSSSE AIWAPYDTGN
SLSAYGGDAG TKSQRRGSLS PTFPEGLEYP LTKSYRSDLS STSEAGHPIY IPAFSNSSNS
YSSSNGGSTS SSPPETRRKH DCVICFDNEV IAALVPCGHN LFCMDCANKI CEKELPLCPV
CQSKVNQAIQ IHS
//
