ID PO3F3_PIG Reviewed; 131 AA.
AC Q29087;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 08-NOV-2023, entry version 120.
DE RecName: Full=POU domain, class 3, transcription factor 3;
DE AltName: Full=Brain-specific homeobox/POU domain protein 1;
DE Short=Brain-1;
DE Short=Brn-1;
DE Flags: Fragment;
GN Name=POU3F3; Synonyms=BRN1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus;
RA Woollard J., Schmitz C.B., Tuggle C.K.;
RL Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that acts synergistically with SOX11 and
CC SOX4. Plays a role in neuronal development. Is implicated in an
CC enhancer activity at the embryonic met-mesencephalic junction; the
CC enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By
CC similarity). {ECO:0000250|UniProtKB:P31361,
CC ECO:0000250|UniProtKB:Q63262}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P20264}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00530}.
CC -!- TISSUE SPECIFICITY: Brain.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC subfamily. {ECO:0000305}.
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DR EMBL; L28764; AAA31106.1; -; mRNA.
DR AlphaFoldDB; Q29087; -.
DR SMR; Q29087; -.
DR STRING; 9823.ENSSSCP00000026394; -.
DR PaxDb; 9823-ENSSSCP00000026394; -.
DR eggNOG; KOG3802; Eukaryota.
DR InParanoid; Q29087; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Proteomes; UP000694570; Unplaced.
DR Proteomes; UP000694571; Unplaced.
DR Proteomes; UP000694720; Unplaced.
DR Proteomes; UP000694722; Unplaced.
DR Proteomes; UP000694723; Unplaced.
DR Proteomes; UP000694724; Unplaced.
DR Proteomes; UP000694725; Unplaced.
DR Proteomes; UP000694726; Unplaced.
DR Proteomes; UP000694727; Unplaced.
DR Proteomes; UP000694728; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0072218; P:metanephric ascending thin limb development; ISS:UniProtKB.
DR GO; GO:0072240; P:metanephric DCT cell differentiation; ISS:UniProtKB.
DR GO; GO:0072236; P:metanephric loop of Henle development; ISS:UniProtKB.
DR GO; GO:0072227; P:metanephric macula densa development; ISS:UniProtKB.
DR GO; GO:0072233; P:metanephric thick ascending limb development; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR PANTHER; PTHR11636:SF125; POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 3; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN <1..>131
FT /note="POU domain, class 3, transcription factor 3"
FT /id="PRO_0000100729"
FT DOMAIN <1..60
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 78..>131
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT NON_TER 1
FT NON_TER 131
SQ SEQUENCE 131 AA; 14724 MW; ECD06A9A857B7127 CRC64;
FTQRRMKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP LLNKWLEEAD
SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GALESHFLKC PKPSAQEITN LADSLQLEKE
VVRVWFCNNL Q
//
