ID NAA25_DROPS Reviewed; 962 AA.
AC Q294E0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Phagocyte signaling-impaired protein;
DE AltName: Full=N-terminal acetyltransferase B complex subunit MDM20 homolog;
DE AltName: Full=N-terminal acetyltransferase B complex subunit NAA25 homolog;
GN Name=psidin {ECO:0000250|UniProtKB:Q9VDQ7}; ORFNames=GA18473;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes
CC acetylation of the N-terminal methionine residues of proteins beginning
CC with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval
CC immune response: required both for the phagocytic degradation of
CC internalized bacteria and for the induction of Defensin in the fat
CC body. Within the phagocytic blood cells, has a role in detection of
CC infection and activation of the humoral immune response (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB)
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q9VDQ7}.
CC Note=Blood cell lysosomes. {ECO:0000250|UniProtKB:Q9VDQ7}.
CC -!- SIMILARITY: Belongs to the MDM20/NAA25 family. {ECO:0000305}.
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DR EMBL; CM000070; EAL29024.2; -; Genomic_DNA.
DR RefSeq; XP_001359872.2; XM_001359835.3.
DR AlphaFoldDB; Q294E0; -.
DR SMR; Q294E0; -.
DR STRING; 46245.Q294E0; -.
DR EnsemblMetazoa; FBtr0282680; FBpp0281118; FBgn0078475.
DR GeneID; 4803072; -.
DR KEGG; dpo:4803072; -.
DR eggNOG; KOG2053; Eukaryota.
DR HOGENOM; CLU_008075_0_0_1; -.
DR InParanoid; Q294E0; -.
DR OMA; WKRREHQ; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0078475; Expressed in adult organism and 3 other cell types or tissues.
DR GO; GO:1990761; C:growth cone lamellipodium; IEA:EnsemblMetazoa.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0031416; C:NatB complex; IEA:EnsemblMetazoa.
DR GO; GO:0051015; F:actin filament binding; IEA:EnsemblMetazoa.
DR GO; GO:0030042; P:actin filament depolymerization; IEA:EnsemblMetazoa.
DR GO; GO:0002253; P:activation of immune response; IEA:EnsemblMetazoa.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:EnsemblMetazoa.
DR GO; GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
DR GO; GO:0010592; P:positive regulation of lamellipodium assembly; IEA:EnsemblMetazoa.
DR GO; GO:0097374; P:sensory neuron axon guidance; IEA:EnsemblMetazoa.
DR Gene3D; 1.25.40.1040; -; 1.
DR InterPro; IPR019183; NAA25_NatB_aux_su.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR22767:SF3; N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT; 1.
DR PANTHER; PTHR22767; N-TERMINAL ACETYLTRANSFERASE-RELATED; 1.
DR Pfam; PF09797; NatB_MDM20; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Antimicrobial; Immunity; Innate immunity; Lysosome; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..962
FT /note="Phagocyte signaling-impaired protein"
FT /id="PRO_0000314626"
FT REPEAT 45..78
FT /note="TPR 1"
FT REPEAT 79..112
FT /note="TPR 2"
FT REPEAT 523..560
FT /note="TPR 3"
FT REGION 856..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 962 AA; 110950 MW; 7B0DAAF2B8107949 CRC64;
MAHQGMDTAL FERRLRPIYD NLEVGNNRKA LQESEKLLRK HPSMLCARAL KGLALLRLGR
YEESHGCLQA VAEDKPTDDS TLQVLSFCYR EMEQLNKIVE LYQHAVKKNP GNEELLAHLF
ISYVRVEDYK AQQAVALQLY KAQPKNAYYF WSVISVVFQG IRGPESAVPE KRKIYLGLAQ
RMVEKHIREG KLESEQEAFL YLHILKLQKK FQEAWEFLTG ELCAKLYPGA PVSMKFELLK
VLGNWRELNE LLQQLLDADR DRWDYYKEYI QSCFEILKLP ITEGATEEKK FSLSACQEFL
QGIIDSSERK KRGPYLARLE LHQRMRAHQL PADQLIGDFD ELVVEYFSLF ADKSCCTHDI
ALFLPSVSMK QRQALANKLL LESGVSSTSL PMNKEQMQKH ICALQISRMC GAHIDLPIDH
LLAFYTALKL HYEHGRSTFG NKLLSTEMGP SDPYALLAAN VMYDISLREN KSDYLFEALC
LLQYVLRNST SNFHVKLLSL KIYHMFGCLL GAQEMYEYLD IKQIQLDSMG YVHCQLLPLC
GRFSGARNSY DTTMKFFTNS YKERLEYIAL TYRFCTFSKM EEFLNFKERL TNSLQYVTCS
LEAQICDLVS CYANVHQNLS TYTVMSIEPA EDRIAWHELS DNRDLDAIIR WDPLHQVDAD
AERKDSFDQE IEVLQLRSLM LRLYATFIDL YHPPPITKPS LSDGSKEETP APAVESATST
LELLRDSWTG LYQRLRLMNY KPLPQQFLVN LLPTRLHLLL ELPYERFFDD LAQLVLDLHS
GAASLAAHCK KVGDNVIAVM ELCVRTIEES NEWNNKDGLW KRRYQQQKVA ASLEMLSLYA
FLLSVLNDKL QVSSKTKVKK KQGDNKTQDT PQPVSEKERS QMVQELMRQL KHKLEACDAA
IRTWKAPVLP RDLSSFMADM SLKPEVEATL IGDVSATFKD SHELMVTELR NLLKDKIRMV
AK
//
