UniProt: Q29EZ8

Database: UniProt
Entry: Q29EZ8_DROPS

LinkDB:  Q29EZ8_DROPS 
Original site:  Q29EZ8_DROPS

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Ontology (6)   
   GO (6)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (20)   
   InterPro (9)   
   Pfam (4)   
   PROSITE (3)   
   SMART (4)   
All databases (29)   

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ID   Q29EZ8_DROPS            Unreviewed;      2415 AA.
AC   Q29EZ8; A0A6I8UAI3;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   04-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   SubName: Full=Spectrin alpha chain isoform X4 {ECO:0000313|RefSeq:XP_001352415.1};
GN   Name=LOC4812090 {ECO:0000313|RefSeq:XP_001352415.1};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001352415.1};
RN   [1] {ECO:0000313|RefSeq:XP_001352415.1}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001352415.1};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_001352415.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the spectrin family.
CC       {ECO:0000256|ARBA:ARBA00006826}.
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DR   RefSeq; XP_001352415.1; XM_001352379.4.
DR   SMR; Q29EZ8; -.
DR   EnsemblMetazoa; FBtr0288123; FBpp0286561; FBgn0075193.
DR   GeneID; 4812090; -.
DR   KEGG; dpo:4812090; -.
DR   eggNOG; KOG0040; Eukaryota.
DR   HOGENOM; CLU_000847_0_0_1; -.
DR   OMA; FQIAQEE; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0075193; Expressed in insect adult head and 2 other cell types or tissues.
DR   ExpressionAtlas; Q29EZ8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR   CDD; cd00176; SPEC; 13.
DR   Gene3D; 1.20.58.60; -; 19.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035825; Alpha_Spectrin_SH3.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF00435; Spectrin; 20.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   PRINTS; PR01887; SPECTRNALPHA.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00150; SPEC; 20.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 16.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
SQ   SEQUENCE   2415 AA;  278417 MW;  A668C1D4C4E38820 CRC64;
     MENFTPKEVK ILETVEDIQE RREQVLSRYN EFKIETRQKR EKLEDSRRFQ YFKRDADELE
     SWIHEKLQAA SEESYRDPTN LQAKIQKHQA FEAEVSAHSN AIVSLDNTGQ EMINQQHFAS
     ETIQRRLDEL HQLWELLLSR LAEKGLKLQQ ALVLVQFLRQ CEEVMFWIKD KETFVTADEF
     GQDLEHVEVL QRKFDEFQKD MASQEYRVTE VNQLADKLIQ DGHPERDTIT KRKEELNEAW
     QRLKQLAIVR QEKLFGAHEI QRFNRDADET VAWIAEKDVV LSSDDYGRDL ASVQALQRKH
     EGVERDLAAL EDKVSTLGAE AQRLCSIHAD HSDQIRDKQS EIANYWQSLT AKARERKQKL
     DESYYLHRFL ADFRDLVSWI NGMKAIISAD ELAKDVAGAE ALLERHQEHK GEIDAREDSF
     KLTTESGQKL LEREHYAAAE IQEKLGALEN DKSSLLSLWE DRRILYEQCM DLQLFYRDTE
     QADTWMAKQE AFLANEDLGD SLDSVEALIK KHEDFEKSLA AQEEKIKALD IFATKLIDGQ
     HYAADDVAQR RQMLLARRAA LQEKSAKRRQ LLEDSNRYQQ FERDCDETKG WISEKLKFAT
     DDSYLDPTNL NGKMQKHQNF EHELNANKSR IEDITNVGTE LIEKQHYAAD QINTRMQEIV
     VLWETLVQAS DKKGCKLNEA CQQQQFNRTI EDIELWLSEI EGQLLSEDHG KDLTSVQNLQ
     KKHALLEADV MAHQDRIESI KVAANKFIES GHFDADNIRN KEGNLSARYA ALAAPMSERK
     QHLSDSLHVQ QLFRDLEDEA AWIREKEPIA ASTNRGRDLI GVQNLIKKHQ AVLAEINNHE
     ARLLNVISSG DNMLKDQPFA SDDIRQRLEA LQEQWNNLKE RSNQRKQDLD DSLQAHQYFA
     DANEAESWMR EKEPIATGSD YGKDEDSSEA LLKKHEALVS DLEAFGNTIQ ALQEQAKNCR
     QQETPVVDIT GKECVVALYD YTEKSPREVS MKKGDVLTLL NSNNKDWWKV EVNDRQGFVP
     AAYIKKIEAG LSASQQNLVD NHSIAKRQNQ INSQYDNLLA LARERQNKLN ETVKAYVLVR
     EAADLAQWIR DKENHAQIAD VVGEDLEEVE VLQKKFDDFN DDLKANEVRL ANMNEIAVQL
     TSLGQTEAAL KIQTQMQDLN EKWNNLQTLT TEKASQLGSA HEVQRFHRDI DETKDWIAEK
     ANALNNDDLG KDLRSVQTLQ RKHEGVERDL AALRDKIRQL DETANRLMQS HPDTAEQTYA
     KQKEINEMWD QIITKSTARK EKLLDSYDLQ RFLSDYRDLL AWINSMMSLV TSDELANDVT
     GAEALIERHQ EHRTEIDARA GTFGAFEQFG NELLQANHYA SPEIKEQIED LAKAREDLEK
     AWTERRLQLE QNLDLQLYMR DCELAESWMS AREAFLNADD DANAGGNVEA LIKKHEDFDK
     AINGHEQKIA ALQTVADQLI AQNHYASTAV DEKRKQVLER WRHLKEGLIE KRSRLGDEQT
     LQQFSRDADE IENWIAEKLQ LATEESYKDP ANIQSKHQKH QAFEAELAAN ADRIQSVLAM
     GGNLIDKKQC SGSEDAVQKR LTQIADQWEY LTHKTTEKSL KLKEANKQRT YIAAVKDLDF
     WLGEVESLLT TEDSGKDLAS VQNLMKKHQL VEADIVAHED RIKDMNNQAD SLVESGQFDT
     AGIQEKRQSI NERYERICNL AAHRQARLNE ALTLHQFFRD IADEESWIKE KKLLVGSDDY
     GRDLTGVQNL KKKHKRLEAE LASHEPAIQA VQEAGEKLMD VSNLGVPEIE QRLKALNQAW
     AELKNLAATR GQKLDESLTY QQFLAQVEEE EAWITEKQQL LSVEDYGDSM AAVQGLLKKH
     DAFETDFTAH KDRCSLICDQ GSELVEAKNH HGDSIAQRCQ QLRNKLENLN ALAARRKGAL
     LDNSAYLQFM WKADVVESWI DDKENYVRSD EFGRDLSTVQ TLLTKQETFD AGLNAFEQEG
     IHNITALKDQ LINASHAQSP AILKRHGDVI ARWQSLRDAS DTRKQRLLAM QEQFRQIEEL
     YLTFAKKASA FNSWFENAEE DLTDPVRCNS IEEIRALRDA HAQFQASLSS AEADFKALAA
     LDQKIKSFNV GPNPYTWFTM EALEETWRNL QKIIEERDGE LAKEAKRQEE NDKLRKEFAK
     HANLFHQWLT ETRTSMMEGS GSLEQQLDAL RVKATEVRAR RVDLKKIEEL GALLEEHLIL
     DNRYTEHSTV GLAQQWDQLD QLSMRMQHNL EQQIQARNHS GVSEDSLKEF SMMFKHFDKD
     KSGKLNHQEF KSCLRALGYD LPMVEEGQPD PEFEAILDVV DPNRDGYVSL QEYIAFMISK
     ETENVQSYEE IENAFRAITA ADRPYVTKEE LYCNLTKDMA DYCVQRMKPF SEPRSGQPIK
     DALDYIDFTR TLFQN
//

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