ID Q29HJ5_DROPS Unreviewed; 528 AA.
AC Q29HJ5; A0A6I8VHM4;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Dynein light intermediate chain {ECO:0000256|RuleBase:RU366047};
GN Name=LOC4814894 {ECO:0000313|RefSeq:XP_001354708.2,
GN ECO:0000313|RefSeq:XP_015041576.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015041576.1};
RN [1] {ECO:0000313|RefSeq:XP_001354708.2, ECO:0000313|RefSeq:XP_015041576.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001354708.2,
RC ECO:0000313|RefSeq:XP_015041576.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001354708.2,
RC ECO:0000313|RefSeq:XP_015041576.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein 1 complex that are thought to be involved in
CC linking dynein to cargos and to adapter proteins that regulate dynein
CC function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules. May
CC play a role in binding dynein to membranous organelles or chromosomes.
CC {ECO:0000256|RuleBase:RU366047}.
CC -!- SUBUNIT: Homodimer. The cytoplasmic dynein 1 complex consists of two
CC catalytic heavy chains (HCs) and a number of non-catalytic subunits
CC presented by intermediate chains (ICs).
CC {ECO:0000256|RuleBase:RU366047}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|RuleBase:RU366047}.
CC -!- SIMILARITY: Belongs to the dynein light intermediate chain family.
CC {ECO:0000256|ARBA:ARBA00006831, ECO:0000256|RuleBase:RU366047}.
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DR RefSeq; XP_001354708.2; XM_001354672.4.
DR RefSeq; XP_015041576.1; XM_015186090.2.
DR STRING; 46245.Q29HJ5; -.
DR EnsemblMetazoa; FBtr0284803; FBpp0283241; FBgn0075165.
DR EnsemblMetazoa; FBtr0378150; FBpp0339019; FBgn0075165.
DR GeneID; 4814894; -.
DR KEGG; dpo:4814894; -.
DR HOGENOM; CLU_021937_2_0_1; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0075165; Expressed in female reproductive system and 3 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:EnsemblMetazoa.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IEA:GOC.
DR GO; GO:0005635; C:nuclear envelope; IEA:EnsemblMetazoa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008088; P:axo-dendritic transport; IEA:EnsemblMetazoa.
DR GO; GO:0007409; P:axonogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0035149; P:lumen formation, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:EnsemblMetazoa.
DR GO; GO:0051028; P:mRNA transport; IEA:EnsemblMetazoa.
DR GO; GO:0048477; P:oogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IEA:EnsemblMetazoa.
DR CDD; cd00267; ABC_ATPase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008467; Dynein1_light_intermed_chain.
DR InterPro; IPR022780; Dynein_light_int_chain.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12688; DYNEIN LIGHT INTERMEDIATE CHAIN; 1.
DR PANTHER; PTHR12688:SF0; DYNEIN LIGHT INTERMEDIATE CHAIN; 1.
DR Pfam; PF05783; DLIC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU366047};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU366047};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU366047}; Dynein {ECO:0000256|RuleBase:RU366047};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU366047};
KW Motor protein {ECO:0000256|RuleBase:RU366047};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU366047};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366047}.
FT REGION 371..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 58496 MW; 01302A138AD85A5A CRC64;
MALESGTQTG SNALTSSFTT KKKDAAAEKE NLWSAILNEV QTQGSTKLPA NKSVLVLGDN
ATGKTTLIAK LQGVEDPKKG SGLEYAYIDV KDEYRDDMTR LGVWVLDGDP GHTNLLHFAL
NETNYAHTLV ILTVSMTQPW GWLEQLNHWI KVLGQHIESL PLEAKDKEMA RQRLATTWQS
YCEVGDDLDP GSPVKRTMRN NSIDEDDLLP LTEDALITNL GLDIVVVVTK TDYMTTLEKE
YEYRDEHFDF IQQWIRSFCL RTGASLFYTS VKEDKNCDLL YKYLTHRIYG LPFRTPALVV
EKDAVLIPAG WDSLKKISIL YENMHGIKAE SPYSDVIKAP PTRKAVSNRE VEVQTEDEQT
FLARQQEILK QAGQDRGESP LRSQGGGGVG GNKSVPRTPG STGQSSPKKI DPKLTPATPG
GEGVLANFFN SLLHKKSGSP GGGGGPPGAG TPTGTTRTSN GTDSLMTPEK LAVRSDAAAE
LDRLSRSVKK EIDLSQNSRP FRSRNAKRHT LLKYVLMKNF RRSHLRRY
//
